Weekly News

Weekly news updates are currently posted on our homepages, weekly news pages and sent directly to your inbox to provide up-to-date information on what has been covered in the news regarding lung cancer, and complementary health & wellness in the previous week.

My Choices News Update

Redefining Cancer: A New Approach to Early Stage Diseases
“The understanding of disease biology for many cancer types has significantly advanced in recent years. However, this progress is not always mirrored in the way cancer is defined and treated. This can lead to overdiagnosis and overtreatment, particularly in cancers such as ductal carcinoma in situ (DCIS) and low-grade prostate cancer, which pose minimal risks for mortality or diminished quality of life.”

Scientists Tame Shapeless Monster Behind 75% of Cancers
“Researchers at UC Riverside have made a groundbreaking discovery in cancer treatment by developing a peptide that can control MYC, a key protein involved in the majority of human cancers. This innovation offers new hope for targeting cancer at a molecular level, paving the way for more effective treatments.”

Revolutionizing Recovery: Ottawa Study Unveils VR Mindfulness as a Beacon for Veterans
“In Ottawa, a revolutionary study by the University of Ottawa uncovers the transformative potential of VR mindfulness training for veterans grappling with substance use recovery. This immersive approach enhances mood, state mindfulness, and overall well-being, shedding light on promising therapeutic interventions for mental health.”

Tai chi reduces blood pressure better than aerobic exercise, study finds
“Tai chi, a traditional, slow-moving form of Chinese martial art, is known to increase flexibility and improve balance. Now, new research suggests it’s better than more vigorous aerobic exercises for lowering blood pressure in people with prehypertension.”

How Exercise Can Help Boost Your Memory
“Forgetting information. Losing focus. Having difficulty doing tasks you used to find easy, like following a recipe or running errands. Struggling to remember the word for that thing…”

Exercise unleashes anti-inflammatory power against autoimmune diseases
“In a recent study published in Journal of Sport and Health Science, a group of researchers evaluated the impact of exercise training on reducing inflammation in adolescents and adults with autoimmune diseases through a systematic review of studies published over two decades.”

Women may get more health benefits from regular exercise than men
“Men and women who exercise regularly are less likely to die prematurely of any cause, including a cardiovascular event, compared to those who are sedentary. Researchers also report that women see more pronounced benefits than men from regular exercise. They added that exercise routines should contain both aerobic exercise and strength training.”

How To Get Sculpted Arms Like Miley Cyrus
“Do you feel like your arms could do with a serious tune-up but can’t afford a personal trainer or gym fees? We share a celebrity-inspired workout you can carry out at home without the celebrity price tag.”

Monday Medical: How integrative medicine can improve your health
“The more physicians and patients explore the many ways integrative medicine can be used to promote health and healing, the more it has become an integral component of American health care. “Both physicians and patients just need to have an open mind,” said Dr. Nicole Cotter, a board-certified rheumatologist and integrative medicine physician at UCHealth Yampa Valley Medical Center. “Every patient can benefit from integrative medicine, and every physician can benefit from introducing elements of it into treating patients. In fact, primary care physicians are probably doing it more than their patients realize. Many people aren’t familiar with the name ‘integrative medicine,’ even though they are likely using it in one form or another.” Surveys show that 40% of Americans participate in some type of integrative medicine. It combines traditional or conventional medical practices with complementary medicine modalities, so patients receive the best of both approaches.”

Lung Cancer News Update

Tagrisso with the addition of chemotherapy approved in the US for patients with EGFR-mutated advanced lung cancer
“AstraZeneca’s has been approved in the US for the treatment of adult patients with locally advanced or metastatic epidermal growth factor receptor-mutated (EGFRm) non-small cell lung cancer (NSCLC). The approval following a Priority Review by the Food and Drug Administration (FDA) was based on the results from the FLAURA2 Phase III trial published in The New England Journal of Medicine. Tagrisso with the addition of chemotherapy reduced the risk of disease progression or death by 38% compared to Tagrisso monotherapy which is the 1st-line global standard of care (hazard ratio [HR] 0.62; 95% confidence interval [CI] 0.49-0.79; p<0.0001). Median progression-free survival (PFS) by investigator assessment was 25.5 months for patients treated with Tagrisso plus chemotherapy, an 8.8-month improvement versus Tagrisso monotherapy (16.7 months).”

Risk-based lung cancer screening in heavy smokers: a benefit–harm and cost-effectiveness modeling study
“Risk-based screening strategies are more efficient in reducing lung cancer deaths and gaining life years compared to the status quo strategy. Risk-stratified screening intervals can potentially balance long-term benefit–harm trade-offs and improve the cost-effectiveness of lung cancer screenings.”

FDA Accepts Dato-DXd Application for Non-Small Cell Lung Cancer
“The BLA for Dato-DXd, a TROP2-directed ADC, in previously treated, advanced, nonsquamous NSCLC has been accepted by the FDA, and a PDUFA target action date is anticipated in the fourth quarter of 2024.”

Reflex Molecular Testing May Enhance Targeted Therapy Benefit in Early-Stage Lung Cancer
“Efforts to standardize and implement reflex testing for biomarkers in early-stage non–small cell lung cancer could allow for earlier identification of appropriate targeted therapies that may be used in treatment, thereby improving patient outcomes, according to Jobelle Baldonado, MD, who adds that it is important for surgical oncologists to stay up to date on the development of targeted agents in lung cancer so they can best treat patients presenting with recurrent disease.”

Work-Related Respirable Crystalline Silica Exposure and Lung Cancer Risk
“Prevention measures should be taken to protect workers who are exposed to respirable crystalline silica (RCS) from lung cancer risk. Researchers assessed a systemic review of 20 studies found using the PubMed database and an online search of RCS limits set by institutional organizations. They sought to determine the cutoff points that could affect risk of mortality or incidence of lung cancer from occupational RCS exposure.”

Osimertinib Yields Activity, Manageable Toxicity in Metastatic EGFR+ NSCLC
“Treatment with osimertinib (Tagrisso) demonstrated clinical activity and a manageable safety profile among patients with metastatic non–small cell lung cancer (NSCLC) harboring EGFR mutations outside of exon 20 insertion mutations, according to findings from the phase 2 UNICORN trial (jRCTs071200002) published in JAMA Oncology.”

‘Help is right here’: Roswell Park brings lung cancer screening to people who need it
“Eddy is Roswell Park Comprehensive Cancer Center’s new mobile lung cancer screening unit – the size of a tractor-trailer – and its mission is in its name: “Early Detection Driven to You.”

Kentucky rises to No. 2 in the nation in screening for lung cancer, which lowers the chances that the disease will be fatal
“Dr. Tony Stumbo’s heart sank after the doctor shared his mother’s chest X-ray. “I remember that drive home, bringing her back home, and we basically cried,” said the internal medicine physician, who had started practicing in Eastern Kentucky near his childhood home in Floyd County shortly before his mother began feeling ill. “Nobody wants to get told they’ve got inoperable lung cancer. I cried because I knew what this meant for her.” Now Stumbo, whose mother died the following year, in 1997, is among a group of Kentucky clinicians and researchers determined to rewrite the script for other families by promoting training and boosting awareness about early detection in the state with the highest lung cancer death rate.”

Study Finds New Inhalable Therapy is a Big Step Forward in Lung Cancer Research
“Newswise — Lung cancer is one of the most common cancers and has one of the lowest survival rates in the world. Cytokines, which are small signaling proteins, such as interleukin-12 (IL-12), have demonstrated considerable potential as robust tumor suppressors. However, their applications are limited due to a multitude of severe side effects.”

Video:

Doctors warn of rise in lung cancer among non-smokers
“One Triad woman was diagnosed at 30 years old. There are three warning signs that you should see a doctor.”

Treatment-Specific Biomarkers, Future of Research for Lung Cancer with Jonathan Spicer, MD, PhD
“In this Lungcast segment, Spicer spoke on several treatment-specific biomarkers for lung cancer and discussed the future of lung cancer therapy.”

My Choices News Update

Georgia State University Researcher Examines State of Warning Labels on Cannabis, Tobacco and Opioid Medications
“ATLANTA — A growing number of states have legalized recreational marijuana use, but a lack of consistency in warning consumers of potential harms threatens public health. That’s one of many takeaways from a review article authored by a Georgia State University School of Public Health researcher and her colleagues that examines the impact of warning labels on tobacco, cannabis and prescription opioids. The article appears in the early online edition of the journal Annual Review of Public Health.”

Harnessing the Power of Mindfulness for Heart Health: Promoting Adherence to the DASH Diet and Beyond
“Recent studies have uncovered intriguing links between mindfulness training and improved adherence to the DASH diet, a diet plan renowned for its cardiovascular benefits. This notable finding emphasizes the potential of mindfulness as a tool for fostering healthier dietary habits, particularly among those battling hypertension. The research offers invaluable insights into the interplay between mindfulness and heart health, shedding new light on the possible advantages of mindfulness practices for managing high blood pressure. The message is clear: adopting a mindful approach to eating could hold the key to better heart health.”

Harnessing the Power of Diaphragmatic Breathing for Stress Relief and Better Health
“In today’s fast-paced world, stress and anxiety have become pervasive issues affecting millions of people. While there are various coping mechanisms, one simple and effective method that often gets overlooked is diaphragmatic breathing. It’s a mindful breathing technique that can be practiced anytime, anywhere, and has been scientifically proven to lower stress and reduce feelings of anxiety.”

Study says long COVID makes exercise difficult, but a North Texas doctor says not impossible
“A recent study found long COVID can adversely affect your ability to exercise. And not just because of chronic fatigue. However, Dr. Salman Bhai, director of the neuromuscular center at the Institute for Exercise and Environmental Medicine at Texas Health Dallas, told KERA’s Sam Baker that with help, an exercise routine is still possible with long COVID.”

You Probably Can’t ‘Exercise Away’ the Calories in Sodas: Study
“Key Takeaways: Working out won’t eliminate the risk to heart health posed by sugary drinks. People consuming sugary drinks more than twice a week had a higher risk of heart disease, regardless of their physical activity levels. Artificially sweetened beverages were not associated with heart risk”

Does Your Blood Type Affect Your Heart Health? Yes, but Here’s the Full Story
“Certain blood types are associated with health problems like blood clotting, but that’s just one piece of the heart health puzzle.”

We asked. You answered. Here are your secrets to healthy aging
“In the 1960s and ’70s, The 2,000 Year-Old Man, was popular a comedy routine performed by Carl Reiner and Mel Brooks. Brooks played a 2,000 year-old man – apparently in terrific health – and Reiner, a modern man, would ask him questions, including if he’d share the secrets to his longevity. “The major thing is that I never ever touch fried food,” was Brooks’ response in one early recording. Also, “Never run for a bus; there will always be another,” and eat lots of nectarines. Not bad! Whether you’re 2,000 or 20, we’re all aging and we all have wisdom and experiences to share. That’s why NPR asked our listeners and readers to share their secrets to living a long and healthy life, as part of our new series, How to Thrive as You Age. To date we’ve received over 1,000 responses from readers and listeners ages 16 to 103.”

Weight-loss drugs aren’t a magic bullet. Lifestyle changes are key to lasting health
“The headlines are compelling, with phrases like, “The Obesity Revolution,” and “A new ‘miracle’ weight-loss drug really works.” The before-and-after pictures are inspiring. People who have struggled for decades to shed pounds are finally finding an effective strategy.”

Lung Cancer News Update

Invasive procedures rarely follow false-positive lung cancer screenings
“Key takeaways: Patients with false-positive lung cancer screening findings did not often undergo Invasive procedures. Procedure complications rarely occurred in patients without malignancy.”

Can your breath be used to detect lung cancer?
“In the first laboratory of its kind in North America, UBC’s Dr. Renelle Myers is harnessing the power of breath in the hopes of saving more lives, sooner.”

Nuvalent Initiates the Phase 2 Portion of ALKOVE-1 Clinical Trial for Patients with ALK-Positive NSCLC and other Solid Tumors
“CAMBRIDGE, Mass., Feb. 12, 2024 /PRNewswire/ — Nuvalent, Inc. (Nasdaq: NUVL), a clinical-stage biopharmaceutical company focused on creating precisely targeted therapies for clinically proven kinase targets in cancer, today announced the initiation of the Phase 2 portion of ALKOVE-1, its Phase 1/2 clinical trial of NVL-655 for patients with ALK-positive non-small cell lung cancer (NSCLC) and other solid tumors, following alignment with the US Food and Drug Administration (FDA) on a recommended Phase 2 dose (RP2D) of 150 mg once daily (QD).”

Enhancing Multidisciplinary Team Processes in Lung Cancer Care: A Self-Assessment Toolkit and Best Practices
“Multidisciplinary teams (MDTs) play a pivotal role in the comprehen­sive management of cancer. MDT meetings (MDTMs) bring together specialized experts across the entire patient care spectrum, convening regularly to discuss patient cases, select optimal diagnostic strategies, and determine the most ap­propriate treatment modalities. By fostering cross-disciplinary interaction, MDTs aim to enhance patient outcomes and elevate the collective proficiency within a health care institution, promoting knowledge dissemination and ensuring health care practitioners remain abreast of the latest clinical insights.”

As cancer treatment advances, patients and doctors push back against drugs’ harsh side effects
“For cancer patients, the harsh side effects of powerful drugs have long been the trade-off for living longer. Now, patients and doctors are questioning whether all that suffering is necessary.”

Worth The Wait? Genomic Testing Delays Initiation of Advanced NSCLC Therapy
“Participants in virtual events discussed the key issue of whether to initiate therapy immediately or wait for test results that could show the best approach in patients with advanced lung cancer.”

How One Type of Lung Cancer Can Transform into Another
“Lung tumors called adenocarcinomas sometimes respond to initially effective treatments by transforming into a much more aggressive small cell lung cancer (SCLC) that spreads rapidly and has few options for treatment. Researchers at Weill Cornell Medicine have developed a mouse model that illuminates this problematic process, known as histological transformation. The findings advance the understanding of how mutated genes can trigger cancer evolution and suggest targets for more effective treatments.”

New immunotherapy borrows cancer’s tricks to unleash powerful T cells
“Immunotherapies using engineered T cells have ushered in a new era in cancer treatment, but they have their limits. They may cause side effects or stop working, and they do not work at all against 90% of cancers. Now, scientists at UC San Francisco and Northwestern Medicine may have found a way around these limitations by borrowing a few tricks from cancer itself.”

Bristol Myers’ (BMY) Opdivo Label Expansion Filings Get Accepted
“Bristol Myers BMY announced the acceptance of its regulatory applications for neoadjuvant Opdivo (nivolumab) with chemotherapy followed by surgery and adjuvant Opdivo for the perioperative treatment of resectable stage IIA to IIIB non-small cell lung cancer (NSCLC) in the United States and EU.”

Quitting smoking greatly reduces the risk of deadly cancers
“In a study that underscores the vast health benefits of quitting smoking, researchers have found compelling evidence that kicking the habit can significantly decrease the risk of developing cancer. The study revealed that the benefits of quitting smoking accumulate over time and are particularly pronounced after the first decade of cessation.”

Video:

3 Decades, 3 Cancers: Stacey Sager’s story of perseverance, sacrifice and survival
“For anyone who has ever faced a cancer diagnosis, Eyewitness News Reporter Stacey Sager describes the importance of speaking up, never giving up, and knowing your own body.”

Clinicians Face Off Regarding New Trials in NSCLC Space
“In a recent Face-Off program hosted by CancerNetwork, experts went head-to-head to discuss recent data on non–small cell lung cancer (NSCLC). The panelists were split into 2 teams, the Jets and the Giants, and presented data regarding recent advancements and pivotal trial results in the field.”

My Choices News Update

If you aren’t getting routine cancer screenings, it may be time to start
“Receiving a diagnosis of cancer is difficult. However, thinking about cancer screening and prevention now could improve your odds of survival if you have the disease. Routine screenings can lead to early detection. These tests are one of the most powerful cancer weapons our clinical experts have in their arsenal to catch cancer early and give patients more treatment options. If you aren’t sure which screenings you need, Karmanos Cancer Institute and McLaren Health Care experts can work with you to come up with a screening plan.”

Study of prior authorization’s impact on cancer treatment reveals ‘signal of danger’
“More than one in five people with cancer did not receive clinician-recommended care due to prior authorization requirements, according to study results. Prior authorization also led to care delay — many of them lasting 2 weeks or longer — as well as increased patient anxiety and administrative burden, findings of a survey-based cross-sectional study showed.”

Unacceptable use of substandard metrics in policy decisions which mandate large reductions in animal-source foods
“Many recent very influential reports, including those from the Global Burden of Disease (GBD) Risk Factor Collaborators, the EAT-Lancet Commission on Food, Planet, Health, and the Lancet Countdown on Health and Climate Change, have recommended dramatic reductions or total exclusion of animal-source foods, particularly ruminant products (red meat and dairy), from the human diet. They strongly suggest that these dietary shifts will not only benefit planetary health but also human health. However, as detailed in this perspective, there are grounds for considerable concern in regard to the quality and transparency of the input data, the validity of the assumptions, and the appropriateness of the statistical modelling, used in the calculation of the global health estimates, which underpin the claimed human health benefits.”

The Health Hazards of Prolonged Sitting at Work and How to Counter Them
“Recent research has amplified concerns about the health risks associated with sitting for prolonged periods at work. A study out of Taipei Medical University has warned that people who are mostly sedentary at work have a 16% higher risk of death from all causes and a 34% higher risk of death from heart disease. This significant finding underscores the potential health dangers of a sedentary lifestyle and emphasizes the urgency of lifestyle changes to diminish such behavior.”

Exercise Reduces Mortality Risk in Various Cancer Types: New Studies
“A new study suggests that exercise can reduce the risk of all-cause mortality across various cancer types, including prostate cancer. This study adds to existing evidence that emphasizes the positive impact of exercise on cancer outcomes. By analyzing several pieces of research, we can gain a better understanding of these findings and their implications for cancer patients and survivors.”

Do your kids want a dog? Science may be on their side
“A new study finds that getting a family dog is linked with a big jump in physical activity in younger kids – especially in young girls. The finding is part of a growing body of research investigating how dogs can boost health, not just for kids but for people of all ages.”

It’s called ‘cozy cardio.’ In a world seeking comfort, some see a happier mode of exercise
“Political polarization. Economic struggles. Inequity. Climate change. War. In an often-bruising world, you can hardly blame people for seeking out ways to cushion themselves. From weighted blankets to “cozy” murder mystery novels to entire restaurants and cookbooks based on childhood comfort foods, the appetite for comfortable things just keeps growing.”

PODCAST:

Try these posture-improving exercises
“SALT LAKE CITY – Posture is a health-related issue that often gets overlooked. Frequent stretching, supportive footwear, and a flat backpack all play a role in improving your posture. In the latest Let’s Get Moving with Maria podcast episode, Maria Shilaos spoke with Fascia and Posture Expert Dr. Liza Egbogah to learn some posture-improving exercises that can help fix the top posture mistakes people make.”

Lung Cancer News Update

6 Ways to Lower Your Cancer Risk
“An estimated 2 million Americans were diagnosed with cancer in 2023, and more than 600,000 died from the disease. According to the American Association for Cancer Research, more than 40% of those cases and nearly half of the deaths can be attributed to preventable causes such as smoking, obesity and excessive exposure to the sun. February is National Cancer Prevention Month. It’s the perfect time to evaluate your lifestyle and make health a priority.”

Genprex Announces First Patient Dosed in Phase 2a Expansion of Acclaim-1 Clinical Study of Reqorsa® Therapy in Combination with Tagrisso® to Treat Non-Small Cell Lung Cancer
“AUSTIN, Texas, Feb. 5, 2024 /PRNewswire/ — Genprex, Inc. (“Genprex” or the “Company”) (NASDAQ: GNPX), a clinical-stage gene therapy company focused on developing life-changing therapies for patients with cancer and diabetes, today announced that in January 2024, the first patient was enrolled and dosed in the Phase 2a expansion portion of the Company’s Acclaim-1 clinical study of Reqorsa® Therapy (quaratusugene ozeplasmid) in combination with AstraZeneca’s Tagrisso® to treat patients with late-stage non-small cell lung cancer (NSCLC).”

Dynamic phenotypic reprogramming and chemoresistance induced by lung fibroblasts in small cell lung cancer
“Small cell lung cancer (SCLC) is heterogenous in phenotype and microenvironment. Dynamic phenotypic reprogramming, leading to heterogeneity, is prevalent in SCLC, while the mechanisms remain incompletely understood. Cancer-associated fibroblasts (CAFs) possess comprehensive roles in cancer progression, while their function in phenotypic reprogramming of SCLC remain elusive.”

Global Cancer Burden May Be Growing Amidst Mounting Need for Cancer Services
“The World Health Organization’s (WHO) cancer agency, the International Agency for Research on Cancer (IARC), has released updated findings of the current global burden of cancer alongside World Cancer Day on February 4, 2023. The WHO indicated that a majority of countries do not adequately finance priority cancer and palliative care services as part of universal health coverage. Lung cancer was also the leading cause of cancer mortality with 1.8 million deaths accounting for 18.7% of the total cancer deaths, followed by colorectal cancer (900,000 deaths, 9.3%), hepatic cancer (760,000 death, 7.8%), breast cancer (670,000 deaths, 6.9%), and gastric cancer (660,000 deaths, 6.8%). Lung cancer’s reemergence as the most common cancer type may have been related to the persistent use of tobacco across Asian countries.

Cancer vaccine being trialled by NHS may herald ‘dawn of a new age’ of treatments
“Two decades of work in the field of cancer vaccines finally starting to bear fruit, experts say”

Lung Cancer Screening and Stigma: Do Smoking-related Differences in Perceived Lung Cancer Stigma Emerge Prior to Diagnosis?
“Conclusions: Sociodemographic variables (rather than smoking-related characteristics) significantly and uniquely differentiated lung cancer screening-eligible adults’ perception of lung cancer stigma. Smoking-related differences in lung cancer stigma may emerge following rather than prior to diagnosis.”

Circ0087385 promotes DNA damage in benzo(a)pyrene-induced lung cancer development by upregulating CYP1A1
“Increasing environmental genotoxic chemicals have been shown to induce epigenetic alterations. However, the interaction between genetics and epigenetics in chemical carcinogenesis is still not fully understood. Here, we constructed an in vitro human lung carcinogenesis model (16HBE-T) by treating human bronchial epithelial cells with a typical significant carcinogen benzo(a)pyrene (BaP).”

Withdrawal of ‘lifeline’ lung cancer drug to be debated in House of Lords
“Ulster Unionist peer Lord Rogan has secured a short debate on the floor of the House of Lords next week (Wednesday 14 February) following the announcement that Takeda Pharmaceuticals is voluntarily withdrawing the drug Mobocertinib for the UK market despite it being a critical lifeline for EGFR positive lung cancer patients.”

Osimertinib May Offer Survival Benefit Over Immunotherapy in Some Patients With Unresectable NSCLC
“Investigators have found that the targeted therapy osimertinib may be associated with improved progression-free survival when administered after chemotherapy and radiation in patients with non–small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations, according to a recent study published by Nassar et al in the Journal of Thoracic Oncology.”

Bevacizumab Combo Does Not Improve Outcomes in Metastatic Nonsquamous NSCLC
“Bevacizumab (Avastin) plus atezolizumab (Tecentriq), carboplatin, and pemetrexed did not result in significantly improved clinical outcomes compared with atezolizumab plus carboplatin and pemetrexed alone in patients with advanced nonsquamous non–small cell lung cancer (NSCLC), according to findings from a phase 3 trial (jRCT2080224500) published in JAMA Oncology.”

Combining genomic biomarkers to guide immunotherapy in non-small cell lung cancer
“Purpose: The clinical value of STK11, KEAP1 and EGFR alterations for guiding immune checkpoint blockade (ICB) therapy in non-small cell lung cancer (NSCLC) remains controversial, as some patients with these proposed resistance biomarkers show durable ICB responses. More specific combinatorial biomarker approaches are urgently needed for this disease.”

Video:

Person-First Language May Mitigate Stigmatization in Lung Cancer Screening
“It is crucial to use person-first language to reduce potential feelings of stigmatization around lung cancer diagnoses and ensure that patients are receiving equitable treatment across the board, according to Lisa Carter-Bawa PhD, MPH, APRN, ANP-C, FAAN.”

Dr Curran on Developing Strategies for Stage III NSCLC Management
“Wally Curran, MD, chief, Piedmont Oncology Institute, discusses current and developing treatment strategies for patients with stage III unresectable non–small cell lung cancer (NSCLC).”

Dr Halmos on Treatment Strategies For EGFR-Mutant NSCLC
“Balazs Halmos, MD, professor, Department of Oncology (Medical Oncology), professor, Department of Medicine (Oncology & Hematology), associate director, Clinical Science, Montefiore Einstein Comprehensive Cancer Center, discusses treatment strategies for patients with EGFR-mutant non–small cell lung cancer (NSCLC).”

My Choices News Update

Study Urges People to Think Twice Before Going on a Diet
“A new qualitative study highlights the negative interpersonal and psychological consequences associated with “yo-yo dieting,” also known as weight cycling. The work underscores how toxic yo-yo dieting can be and how difficult it can be for people to break the cycle. “Yo-yo dieting – unintentionally gaining weight and dieting to lose weight only to gain it back and restart the cycle – is a prevalent part of American culture, with fad diets and lose-weight-quick plans or drugs normalized as people pursue beauty ideals,” says Lynsey Romo, corresponding author of a paper on the study and an associate professor of communication at North Carolina State University.”

Death doulas and bereavement circles: the rise of grief tourism
“If death is the ultimate journey, then it’s no surprise that a whole programme of travel has sprung up around helping us handle our grief. The last few years have seen both personal and collective bereavement on a scale none of us could have imagined. So, in some ways it’s unsurprising that many have begun to venture beyond the traditional avenue of talking therapies, and invest in a holistic adventure to deal with these turbulent emotions.”

American Heart Association spurs “food is medicine” research with new funding
“29 Jan 2024 — To identify effective “food is medicine” approaches that incorporate healthy food into health care delivery, the American Heart Association (AHA) will reward US$7.9 million to 19 research projects as part of its Health Care by Food initiative. The projects will examine the efficacy of adding healthy food provisions to patient care, aiming to help treat, manage and prevent chronic health conditions and alleviate health inequities.”

Already broke your New Year’s diet resolution? You may be better off
“If you’re like most people who make dietary New Year’s resolutions, you’re probably already struggling to stick with them. But you don’t have to blame yourself. Our minds and bodies actively fight against the kinds of restrictive food rules promoted so aggressively in January. Experts in psychology and nutrition have said that giving yourself grace — and giving up the diet mentality altogether — may be the best way to make this a good year.”

Walking Backward Has An Unexpected Effect On Your Health
“You’ve known how to walk since you were about 12 months old, but walking can be the perfect exercise to keep you healthy all your life. A 30-minute brisk walk most days of the week can keep your health in check by reducing your risk of chronic conditions such as type 2 diabetes, osteoporosis, and heart disease. Walking isn’t just good exercise for older adults. It can be incorporated into your weight loss program, and walking up hills or at a faster pace can boost strength and cardio fitness (per Better Health Channel).”

Physical activity and nutrition in relation to resilience: a cross-sectional study
“A healthy lifestyle is often discussed as being a characteristic of or a prerequisite for quality of life. In phases of high subjective stress (work overload, negative thoughts), however, its protective function can be limited. The two present survey studies examined two facets of a health-related lifestyle (physical activity and nutritional awareness), in particular, the correlations with general life satisfaction and their adaptive function in respect to stress (resilience). In addition, because episodes of increased stress can have a negative effect on eating, the interactions with the consumption of less healthy food were examined.”

Control Your Mental Resilience With 10 Stoic Lessons (Stoicism)
“Developing resilience is vital for navigating life’s hardships. The ancient Stoic philosophers of Greece and Rome left enduring lessons that provided mental toughness and emotional fortitude through inevitable adversity. Their powerful teachings reveal how we can take control of our responses to external events that would otherwise threaten inner peace. By applying principles of logic, ethics, and self-discipline, anyone can unlock deep reserves of resilience.”

Patients say keto helps with their mental illness. Science is racing to understand why
“Iain Campbell, a researcher in Scotland, has lived with bipolar disorder since he was young. After trying the ketogenic diet, he discovered profound improvements in his symptoms — and now wants to learn if it can do the same for others. He shared his recent findings at the Metabolic Health Summit in Clearwater, Fla., on Jan. 25.”

Lung Cancer News Update

Why do non-smokers get lung cancer?
“(NEXSTAR) – Last month, actress and comedian Kate Micucci revealed that she had been diagnosed and treated for lung cancer despite “never” having smoked a cigarette in her life. “It was a surprise, but also, I guess it happens,” the “Big Bang Theory” actress said, shortly before confirming she had undergone treatment and is now “cancer-free.”

Breakthrough research identifies predictors of venous thromboembolism after pulmonary resection for lung cancer
“A new study presented at The Society of Thoracic Surgeons’ 2024 Annual Meeting in San Antonio, Texas, examines the ongoing controversy surrounding the choice between multi-arterial grafting (MAG) and single arterial grafting (SAG) in coronary artery bypass grafting (CABG) for multivessel coronary revascularization.”

Safety and efficacy of immune checkpoint inhibitor rechallenge in advanced non-small cell lung cancer: a retrospective study
“We conducted a retrospective study to evaluate the efficacy of immune checkpoint inhibitor (ICI) rechallenge in patients with advanced non-small cell lung cancer (NSCLC). The study included 111 patients who had previously received ICI therapy and experienced disease progression. The primary endpoints assessed were overall survival (OS), progression-free survival (PFS), and objective response rate (ORR). Our findings revealed that the ICI rechallenge showed promising results in improving patient outcomes. OS (r) is the time from rechallenging with immune checkpoint inhibitors to the last follow-up or death from any cause.”

FDA Grants Priority Review to Trastuzumab Deruxtecan for HER2-Positive Solid Tumors
“The FDA has granted priority review to a supplemental biologics license application (sBLA) seeking the approval of the HER2-directed antibody-drug conjugate (ADC) fam-trastuzumab deruxtecan-nxki (T-DXd; Enhertu) for the treatment of adult patients with unresectable or metastatic HER2-positive (immunohistochemistry [IHC] 3+) solid tumors who have received prior treatment or for whom no satisfactory treatment alternatives exist.”

Mirtazapine improves caloric intake compared to placebo in patients with advanced non-small cell lung cancer
“1. While perceived appetite did not differ between study groups, patients receiving mirtazapine had significantly increased caloric consumption compared with the placebo group.

  1. Mirtazapine is well-tolerated, with nightmares being one of the primary significant adverse events, but the difference was insignificant at both the 4- and 8-week follow-up points.”

Study identifies risk factors for deadly blood clots after lung cancer surgery
“In patients who undergo pulmonary resection for lung cancer, a major potential postoperative complication is venous thromboembolism (VTE)-;a condition that develops when a blood clot forms in a vein-;which can lead to part of the clot breaking off and lodging in the lung, resulting in a pulmonary embolism (PE).”

Is lung cancer treatment working? This chip can tell from a blood draw
“By trapping and concentrating tiny numbers of cancer cells from blood samples, the device can identify whether a treatment is effective at the four-week mark”

SAINT FRANCIS PULMONOLOGIST URGES IMPORTANCE OF LUNG CANCER SCREENINGS
“A new study says Oklahoma ranks 40th in the country for the number of people who survive lung cancer. Doctors have recently changed the guidelines for who can get screened for lung cancer, but in Oklahoma, only 1.7% of people who are eligible to get screened actually do.”

Response score-based protein structure analysis for cancer prediction aided by the Internet of Things
“Medical diagnosis through prediction and analysis is par excellence in integrating modern technologies such as the Internet of Things (IoT). With the aid of such technologies, clinical assessments are eased with protracted computing. Specifically, cancer research through structure prediction and analysis is improved through human and machine interventions sustaining precision improvements. This article, therefore, introduces a Protein Structure Prediction Technique based on Three-Dimensional Sequence. This sequence is modeled using amino acids and their folds observed during the pre-initial cancer stages.”

How genomic testing is reshaping the way we find and treat cancer
“Cancer is a disease of the genome. In cancer, diagnoses are done largely by looking through the microscope at the appearance of cancer cells and, often, the organ the cancer comes from offers the most important way of making the diagnosis. But, over the past couple of decades, doctors and researchers have realised that a much better way to diagnose cancer is by the molecular abnormalities that distinguish cancer cells from normal ones; these abnormalities are often changes in the DNA sequence in the genome of the cancer cells.”

KRAS Mutation in NSCLC Linked to Female Sex, Presence of CNS Metastasis
“The treatment armamentarium for non-small cell lung cancer (NSCLC) is evolving, with increased focus on biomarkers for individualized treatment decisions. Current diagnostic guidelines include treatment-predictive molecular testing for several oncogenic drivers for targeted therapy. Adenocarcinoma and squamous cell carcinoma (SCC) are the two largest histologic subgroups of NSCLC and are genetically different regarding patterns of acquired oncogenic mutations.”

Multi-omics analysis reveals immune features associated with immunotherapy benefit in squamous cell lung cancer patients from Phase III Lung-MAP S1400I trial
“Conclusions: The frequency, distribution and clustering of immune cells relative to malignant ones can impact ICI efficacy in SqNSCLC patients. High CNV burden may contribute to the cold immune microenvironment. Soluble inflammation/immune-related proteins in the blood have the potential to monitor therapeutic benefit from ICI treatment in SqNSCLC patients.”

Treatment Duration With ICIs Impacts Prognosis in Patients With NSCLC
“Immune checkpoint inhibitor (ICI) ± chemotherapy has been shown to prolong survival in patients with advanced non-small cell lung cancer (NSCLC). Some recent sponsor-initiated clinical trials used a fixed 24-month duration or continuous treatment until documented disease progression for investigational ICIs. Additionally, an exploratory analysis of CheckMate 153, which evaluated the impact of continuous versus 1-year fixed-duration ICI treatment protocol in previously treated patients with advanced NSCLC, showed that the continuous use of ICI beyond 1 year improves prognosis.”

FDA grants 510(k) clearance to AI-based lung segmentation software
“The FDA has granted 510(k) clearance to LungQ 3.0.0, an artificial intelligence-based software that identifies different parts of lung anatomy and evaluates lung tissue and fissure completeness, according to a press release. With use of this version of LungQ (Thirona), the release said physicians will feel supported when diagnosing and documenting pulmonary tissue images since the software identifies and separates pulmonary segments and subsegments.”

Survey of US oncologists highlights advanced lung cancer research gaps
“A new survey commissioned by the Cancer Research Institute (CRI) and Regeneron Pharmaceuticals has highlighted that more research is needed to improve treatment for advanced non-small cell lung cancer (NSCLC). Responsible for around 85% of all lung cancers, NSCLC is any type of epithelial lung cancer other than small cell lung cancer.”

My Choices News Update

Is Canned Fruit Healthy? Here’s What Dietitians Say
“Ever wondered if reaching for that can of peaches or pineapple is a good choice for your health? In this deep dive, we’ll talk about the health benefits of canned fruit, debunk common misconceptions and provide practical tips for incorporating canned fruit into a healthy diet.”

Experts Recommend Caution on the Use of Non-Sugar Sweeteners
“WASHINGTON (Jan. 22, 2024) — Despite ongoing concerns about the health impacts of non-sugar sweeteners such as aspartame, sucralose and stevia, these sweeteners are increasingly found in a variety of foods and beverages, including those aimed at children. A viewpoint published in JAMA Pediatrics by three experts on the topic emphasizes that research on the health effects of non-sugar sweeteners in children is urgently needed.”

OPINION: Oregon should take action to increase transparency on medication prices
“When reviewing Oregon’s actions on health care this past year, it’s easy to think that ever-rising medication costs were a priority for lawmakers. In reality, the state continues to leave critical options on the table — and Oregonians unable to afford urgently-needed prescription drugs.”

SNAP to it, Congress — we need to address the obesity crisis now
“The United States has witnessed historic and escalating rates of obesity among adults in recent decades. As of 2020, official government statistics indicate that obesity inflicts 42 percent of Americans, including one in five children.”

Weight gain in children and adults linked to 100% fruit juice, study says
“(CNN) — Drinking a glass or more of 100% fruit juice each day was linked to a small increase in weight in children and adults, according to a new analysis of prior studies. “One fundamental problem with juice is quantity; consuming fruit this way makes it so easy to overdose,” said coauthor and leading nutrition researcher Dr. Walter Willett, a professor of epidemiology and nutrition at Harvard T.H. Chan School of Public Health and professor of medicine at Harvard Medical School in Boston. “For example, how often do we eat three oranges? Yet, a glass of OJ is about three oranges that can be consumed in a minute or two, and we can go back and have another, and that will add many calories and lead to a spike in blood glucose,” Willett said in an email.”

Study provides new evidence of weight loss benefits for type 2 diabetes patients
“Researchers in the School of Population Health at RCSI University of Medicine and Health Sciences have provided new evidence of the health benefits of weight loss efforts that lead to diabetes remission for type 2 diabetes patients. For participants in the weight-loss trial who were able to achieve remission i.e. reduce the need for medications and reduce their HbA1c levels (a measure of blood sugar control), the research found there was a 40% lower rate of cardiovascular disease and 33% lower rate of chronic kidney disease in this group.”

You can boost your longevity with 7 habits that take 5 minutes or less a day, according to a doctor
“Simple daily routines may help extend your lifespan without taking much time. Practices such as ‘micro-meditations’ and exercise breaks can relieve stress and enhance well-being. Gratitude lists and social interaction can cultivate emotional health for a longer life.”

Lung Cancer News Update

Reducing Radon Decreases Exposure To Lung Cancer
“LINCOLN – More than 21,000 lung cancer deaths a year are from exposure to radon gas, according to the Centers for Disease Control. Nebraska is third in the nation with the potential for high radon levels behind Iowa and Pennsylvania. The most vulnerable area in Nebraska is the eastern third of the state due to a layer of rock closer to the surface compared to other areas of the country.”

Gilead says Trodelvy fails to meet primary goal in 2nd-line lung cancer trial
“Jan 22 (Reuters) – Gilead Sciences on Monday said a late-stage trial of its antibody-drug conjugate Trodelvy failed to show that it significantly improved survival for previously treated patients with advanced non-small cell lung cancer (NSCLC).”

Normalcy Following a Life-Threatening Cancer Diagnosis
“On January 2, 2020, my oncologist, Dr. G, told me I was in remission from stage 3B lung cancer. My husband and I stopped at Dunkin Donuts on the way home to celebrate, and the clerk at the donut shop gave us our blueberry muffins free of charge. That day was special; it was the beginning of two and a half months of excitement, joy, hope and optimism about the future. After that I looked forward to a lot of what I called, normalcy.”

PET/CT improves diagnostic biopsy rates in lung cancer patients
“PET/CT imaging can serve as a metabolic guide to increase the accuracy of needle biopsies in patients with suspicious lung nodules, according to a study published January 18 in the European Journal of Radiology. A team that included researchers in the U.K., Greece, and the U.S. studied whether F-18 FDG-PET/CT scans showing metabolic activity of suspicious nodules improved the accuracy of CT-guided biopsies, and the group recommended the approach based on the results.”

Patient finds hope after failed lung cancer treatment
“After receiving a second opinion at Norton Cancer Institute, a lung cancer patient gets a second chance at life.”

Evolving Landscape of Genetic Testing in Oncology
“The use of genetic testing in oncology has expanded in recent years, and there has been a transformative impact of understanding DNA in cancer. Identifying genetic abnormalities in cancer cells, characterizing tumors, and using molecular markers for targeted therapies can make significant differences in creating treatment plans.”

High-Dose Radiotherapy Plus Chemotherapy Is Effective in Locally Advanced NSCLC
“A combination of high-dose stereotactic ablative radiation (SABR) plus chemotherapy showed an acceptable safety profile and efficacy as a treatment for patients with locally advanced non–small cell lung cancer that is not suitable for surgery, according to a study conducted by University of California Los Angeles (UCLA) Health Jonsson Comprehensive Cancer Center.”

Taletrectinib Continues to Demonstrate High Clinical Activity in Advanced ROS1+ NSCLC
“Treatment with the next-generation ROS1 TKI taletrectinib (AB-106) yielded robust, durable, and consistent overall and intracranial responses in patients with locally advanced or metastatic ROS1-positive non–small cell lung cancer (NSCLC) who were ROS1 TKI naive and with prior exposure to a ROS1 TKI, according to data from the phase 2 TRUST-II trial (NCT04919811) that were presented during the 2023 ESMO Congress.”

Video:

‘Terrifying’ footage shows breathing with a normal lung compared to a smoker’s lung
“A video showing the effects smoking has on lungs has been shared online, giving many a serious reality check when it comes to smoking. There’s no denying how bad smoking is for your health, but seeing it up close and personal really shows how much damage it can do.”

Woman inspired by mom’s cancer battle hoping to run Boston Marathon in her honor
RIVIERA BEACH — How far will you go for your mom? For a Palm Beach County woman the answer is all the way to the Boston marathon. The race is scheduled for April 15.”

Weekly News Update.
Caring Ambassadors Program provides 3 weekly news updates covering Lung Cancer News, Hepatitis C News, and My Choices© Update. Receive them delivered weekly to your inbox.

Lung Cancer Choices 6th Edition can be a useful tool for anyone who is caring for someone with lung cancer, but its primary focus is on the patient.

This book is suitable for both the newly diagnosed and those who have been living with lung cancer for some time.