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Monthly Pubmed Review

Monthly Pubmed Review of the Most Relevant Research on Lung Cancer
Literature Review, August 2014


Co-targeting c-Met and COX-2 Leads to Enhanced Inhibition of Lung Tumorigenesis in a Murine Model with Heightened Airway HGF.Stabile LP1, Rothstein ME, Gubish CT, Cunningham DE, Lee N, Siegfried JM. J Thorac Oncol. 2014 Jul 23. [Epub ahead of print]

Exercise-induced lung cancer regression: Mechanistic findings from a mouse model. Higgins KA1, Park D, Lee GY, Curran WJ, Deng X. Cancer. 2014 Jul 2. doi: 10.1002/cncr.28878. [Epub ahead of print]

Comparison of the serum fibrin-fibrinogen degradation products with cytokeratin 19 fragment as biomarkers in patients with lung cancer.So HJ1, Hong SI2, Lee JK2, Chang YH2, Kang SJ1, Hong YJ2. Biomed Rep. 2014 Sep;2(5):737-742. Epub 2014 Jul 11.

Suppression of AKT expression by miR-153 produced anti-tumor activity in lung cancer.Yuan Y1, Du W, Wang Y, et al. Int J Cancer. 2014 Jul 28. doi: 10.1002/ijc.29103. [Epub ahead of print]

Melatonin Inhibits the Migration of Human Lung Adenocarcinoma A549 Cell Lines InvolvingJNK/MAPK Pathway. Zhou Q1, Gui S2, Zhou Q3, Wang Y3. PLoS One. 2014 Jul 3;9(7):e101132. doi: 10.1371/journal.pone.0101132. eCollection 2014.

HMGB1-mediated autophagy promotes docetaxel resistance in human lung adenocarcinoma. Pan B, Chen D, Huang J, Wang R, Feng B, Song H, Chen L. Mol Cancer. 2014 Jul 5;13(1):165. [Epub ahead of print]

 Combined operative technique with anterior surgical approach and video-assisted thoracoscopic surgical lobectomy for anterior superior sulcus tumours. Yokoyama Y1, Chen F1, Aoyama A1, Sato T1, Date H2. Interact Cardiovasc Thorac Surg. 2014 Jul 15. pii: ivu231. [Epub ahead of print]



Sample features associated with success rates in population-based EGFR mutation testing.Shiau CJ1, Babwah JP, da Cunha Santos G, et al. J Thorac Oncol. 2014 Jul;9(7):947-56. doi: 10.1097/JTO.0000000000000196.


Impact of lung cancer screening results on participant health-related quality of life and state anxiety in the National Lung Screening Trial. Gareen IF1, Duan F, Greco EM, et al. Cancer. 2014 Jul 25. doi: 10.1002/cncr.28833. [Epub ahead of print]


Upregulation of Cytoskeleton Protein and Extracellular Matrix Protein Induced by Stromal-Derived Nitric Oxide Promotes Lung Cancer Invasion and Metastasis.Zhang L, Liu J, Wang X, et al. Curr Mol Med. 2014 Jul 23. [Epub ahead of print]

Lung cancer commonly metastasizes to lymph nodes, brain and bones, which is the main cause of death.


A panel of protein markers for the early detection of lung cancer with bronchial brushing specimens.Liu YZ1, Jiang YY, Wang BS, et al. Cancer Cytopathol. 2014 Jul 9. doi: 10.1002/cncy.21461. [Epub ahead of print]

and KIAA0317 was identified as the best combination, with sensitivity of 81.1% (309 of 381 specimens)


Serum biomarkers reflecting specific tumor tissue remodeling processes are valuable diagnostic tools for lung cancer.Willumsen N1, Bager CL, Leeming DJ, et al. Cancer Med. 2014 Jul 18. doi: 10.1002/cam4.303. [Epub ahead of print]


Augmented Meaningful Use Criteria to Identify Patients Eligible for Lung Cancer Screening.

Raz DJ1, Dunham R2, Tiep B3, Sandoval A3, Grannis F4, Rotter A5, Kim JY4. Ann Thorac Surg. 2014 Jul 23. pii: S0003-4975(14)00953-9. doi: 10.1016/j.athoracsur.2014.04.105. [Epub ahead of print]


Transthyretin as a potential biomarker for the differential diagnosis between lung cancer and lung infection.Ding H1, Liu J2, Xue R3, Zhao P3, Qin Y4, Zheng F4, Sun X4. Biomed Rep. 2014 Sep;2(5):765-769. Epub 2014 Jul 11.


Lung resection outcomes and costs in washington state: a case for regional quality improvement.

Farjah F1, Varghese TK2, Costas K3, et al. Ann Thorac Surg. 2014 Jul;98(1):175-82. doi: 10.1016/j.athoracsur.2014.03.014. Epub 2014 May 1.


Prevalence and Clinical Outcomes for Patients With ALK-Positive Resected Stage I to III Adenocarcinoma: Results From the European Thoracic Oncology Platform Lungscape Project.

Blackhall FH1, Peters S1, Bubendorf L1, et al. J Clin Oncol. 2014 Jul 28. pii: JCO.2013.54.5921. [Epub ahead of print]


Surgical Considerations in Older Adults With Cancer.Korc-Grodzicki B1, Downey RJ2, Shahrokni A2, Kingham TP2, Patel SG2, Audisio RA2. J Clin Oncol. 2014 Jul 28. pii: JCO.2014.55.0962. [Epub ahead of print]


Is Sleeve Lobectomy Comparable in Terms of Short- and Long-Term Results With Pneumonectomy After Induction Therapy? A Multicenter Analysis.Cusumano G1, Marra A2, Lococo F3, et al. Ann Thorac Surg. 2014 Jul 15. pii: S0003-4975(14)00942-4. doi: 10.1016/j.athoracsur.2014.04.095. [Epub ahead of print]


Sex differences in early outcomes after lung cancer resection: analysis of the Society of Thoracic Surgeons General Thoracic Database. Tong BC1, Kosinski AS2, Burfeind WR Jr3, et al. J Thorac Cardiovasc Surg. 2014 Jul;148(1):13-8. doi: 10.1016/j.jtcvs.2014.03.012. Epub 2014 Mar 14.


Comparison of the effects of pulmonary rehabilitation with chest physical therapy on the levels of fibrinogen and albumin in patients with lung cancer awaiting lung resection: a randomized clinical trial.Morano MT, Mesquita R, Da Silva GP, et al. BMC Pulm Med. 2014 Jul 28;14(1):121. [Epub ahead of print]


A Propensity-Matched Analysis of Wedge Resection and Stereotactic Body Radiotherapy for Early Stage Lung Cancer.Port JL1, Parashar B2, Osakwe N1, Nasar A1, Lee PC1, Paul S1, Stiles BM1, Altorki NK3. Ann Thorac Surg. 2014 Jul 29. pii: S0003-4975(14)01040-6. doi: 10.1016/j.athoracsur.2014.04.128. [Epub ahead of print]



Multicenter phase II study evaluating docetaxel and cisplatin as neoadjuvant induction regimen prior to surgery or radiochemotherapy with docetaxel, followed by adjuvant docetaxel therapy in chemonaive patients with NSCLC stage II, IIIA and IIIB (TAX-AT 1.203 Trial).Kocher F1, Pircher A2, Mohn-Staudner A3, et al. Lung Cancer. 2014 Jul 3. pii: S0169-5002(14)00277-3. doi: 10.1016/j.lungcan.2014.06.019. [Epub ahead of print]


Use of Hematopoietic Growth Factors in Elderly Lung Cancer Patients Receiving Chemotherapy: A SEER-Medicare-based Study.Rajan SS1, Cai Y, Yi M, Tsai CL, Du XL. Am J Clin Oncol. 2014 Jul 25. [Epub ahead of print]

high cost of HGFs, future studies are also needed to determine cost-effectiveness of these drugs among lung cancer patients.


EGFR biomarkers predict benefit from vandetanib in combination with docetaxel in a randomized phase III study of second line treatment for patients with advanced non-small cell lung cancer.

Heymach JV1, Lockwood SJ2, Herbst RS3, Johnson BE4, Ryan AJ5. Ann Oncol. 2014 Jul 23. pii: mdu269. [Epub ahead of print]


Final efficacy and safety results of pemetrexed continuation maintenance therapy in the elderly from the PARAMOUNT phase III study.Gridelli C1, de Marinis F, Thomas M, et al. J Thorac Oncol. 2014 Jul;9(7):991-7. doi: 10.1097/JTO.0000000000000207.


Randomized open-label non-comparative multicenter phase II trial of sequential erlotinib and docetaxel versus docetaxel alone in patients with non-small-cell lung cancer after failure of first-line chemotherapy: GFPC 10.02 study.Auliac JB1, Chouaid C2, Greiller L3, et al. Lung Cancer. 2014 Jul 17. pii: S0169-5002(14)00306-7. doi: 10.1016/j.lungcan.2014.07.006. [Epub ahead of print]


Impact of the number of metastatic brain lesions on survival after Gamma Knife radiosurgery.

Bashir A1, Hodge CJ Jr2, Dababneh H3, Hussain M3, Hahn S4, Canute GW2. J Clin Neurosci. 2014 Jul 15. pii: S0967-5868(14)00281-1. doi: 10.1016/j.jocn.2014.03.026. [Epub ahead of print]


Comparison of radiation-induced normal lung tissue density changes for patients from multiple institutions receiving conventional or hypofractionated treatments.Diot Q1, Marks LB2, Bentzen SM3, et al. Int J Radiat Oncol Biol Phys. 2014 Jul 1;89(3):626-32. doi: 10.1016/j.ijrobp.2014.03.022.


Lymphopenia association with gross tumor volume and lung v5 and its effects on non-small cell lung cancer patient outcomes.Tang C1, Liao Z2, Gomez D1, et al. Int J Radiat Oncol Biol Phys. 2014 Aug 1;89(5):1084-91. doi: 10.1016/j.ijrobp.2014.04.025. Epub 2014 Jul 8.


Significance of targeted therapy and genetic alterations in EGFR, ALK, or KRAS on survival in patients with non-small cell lung cancer treated with radiotherapy for brain metastases.Mak KS, Gainor JF, Niemierko A, et al. Neuro Oncol. 2014 Jul 22. pii: nou146. [Epub ahead of print]


Patterns of care among patients receiving radiation therapy for bone metastases at a large academic institution.Ellsworth SG1, Alcorn SR2, Hales RK1, McNutt TR1, DeWeese TL1, Smith TJ3. Int J Radiat Oncol Biol Phys. 2014 Aug 1;89(5):1100-5. doi: 10.1016/j.ijrobp.2014.04.028. Epub 2014 Jul 8.


Local control after fractionated stereotactic radiation therapy for brain metastases.Rajakesari S1, Arvold ND, Jimenez RB, et al. J Neurooncol. 2014 Jul 25. [Epub ahead of print]


Impact of pretreatment tumor growth rate on outcome of early-stage lung cancer treated with stereotactic body radiation therapy.Atallah S1, Cho BC1, Allibhai Z1, Taremi M1, et al. Int J Radiat Oncol Biol Phys. 2014 Jul 1;89(3):532-8. doi: 10.1016/j.ijrobp.2014.03.003.


Randomized Trial of Erlotinib Plus Whole-Brain Radiotherapy for NSCLC Patients With Multiple Brain Metastases.Lee SM1, Lewanski CR2, Counsell N2, et al. J Natl Cancer Inst. 2014 Jul 16;106(7). pii: dju151. doi: 10.1093/jnci/dju151. Print 2014 Jul.


Feasibility and potential utility of multicomponent exhaled breath analysis for predicting development of radiation pneumonitis after stereotactic ablative radiotherapy.Moré JM1, Eclov NC, Chung MP, et al. J Thorac Oncol. 2014 Jul;9(7):957-64. doi: 10.1097/JTO.0000000000000182.


Interrater Reliability of the Categorization of Late Radiographic Changes After Lung Stereotactic Body Radiation Therapy.Faruqi S1, Giuliani ME2, Raziee H1, et al. Int J Radiat Oncol Biol Phys. 2014 Aug 1;89(5):1076-83. doi: 10.1016/j.ijrobp.2014.04.042. Epub 2014 Jul 8.


Salvage Stereotactic Body Radiation Therapy (SBRT) for Local Failure After Primary Lung SBRT.

Hearn JW1, Videtic GM2, Djemil T2, Stephans KL2. Int J Radiat Oncol Biol Phys. 2014 Jul 10. pii: S0360-3016(14)00699-3. doi: 10.1016/j.ijrobp.2014.05.048. [Epub ahead of print]



Time-adjusted internal target volume: a novel approach focusing on heterogeneity of tumor motion based on 4-dimensional computed tomography imaging for radiation therapy planning of lung cancer. Nishibuchi I1, Kimura T2, Nakashima T3, et al. Int J Radiat Oncol Biol Phys. 2014 Aug 1;89(5):1129-37. doi: 10.1016/j.ijrobp.2014.04.050. Epub 2014 Jul 8.



PD-1 Pathway Inhibitors: Changing the Landscape of Cancer Immunotherapy. Dolan DE1, Gupta S. Cancer Control. 2014 Jul;21(3):231-7.


Prognostic Significance of Visceral Pleural Involvement in Early Stage Lung Cancer.Lakha S, Gomez JE, Flores RM, Wisnivesky JP. Chest. 2014 Jul 17. doi: 10.1378/chest.14-0204. [Epub ahead of print]



Low-dose Irinotecan as a Second-line Chemotherapy for Recurrent Small Cell Lung Cancer. Morise M1, Niho S2, Umemura S1, Matsumoto S1, et al. Jpn J Clin Oncol. 2014 Jul 23. pii: hyu094. [Epub ahead of print]




Prognostic significance of pretreatment laboratory parameters in combined small-cell lung cancer.


Wang X1, Jiang R, Li K. Cell Biochem Biophys. 2014 Jul;69(3):633-40. doi: 10.1007/s12013-014-9845-3.




Multiplexing Determination of Small Cell Lung Cancer Biomarkers and Their Isovariants in Serum by Immunocapture LC-MS/MS.  Torsetnes SB1, Levernæs MS, Broughton MN, Paus E, Halvorsen TG, Reubsaet L. Anal Chem. 2014 Jul 15;86(14):6983-92. doi: 10.1021/ac500986t. Epub 2014 Jul 1.




Southwest Oncology Group S0802: A Randomized, Phase II Trial of Weekly Topotecan With and Without Ziv-Aflibercept in Patients With Platinum-Treated Small-Cell Lung Cancer.


Allen JW1, Moon J2, Redman M2, et al. J Clin Oncol. 2014 Jul 7. pii: JCO.2013.51.4109. [Epub ahead of print]





Randomized double-blind trial of prophylactic topical Evozac(®) Calming Skin Spray for gefitinib-associated acne-like eruption.Wang Y, Yang Y, Xu J, Yu J, Liu X, Gao R, Zhang L. Onco Targets Ther. 2014 Jul 10;7:1261-6. doi: 10.2147/OTT.S65961. eCollection 2014.

Psychological wellness and health-related stigma: a pilot study of an acceptance-focused cognitive behavioural intervention for people with lung cancer.Chambers SK1, Morris BA, Clutton S, et al. Eur J Cancer Care (Engl). 2014 Jul 23. doi: 10.1111/ecc.12221. [Epub ahead of print]

Disparities in perceived unmet need for supportive services among patients with lung cancer in the Cancer Care Outcomes Research and Surveillance Consortium. John DA1, Kawachi I, Lathan CS, Ayanian JZ. Cancer. 2014 Jul 1. doi: 10.1002/cncr.28801. [Epub ahead of print]


Studies on Cytotoxic Constituents from the Leaves of Elaeagnus oldhamii Maxim. in Non-Small Cell Lung Cancer A549 Cells. Liao CR1, Kuo YH1, Ho YL2, Wang CY1, Yang CS1, Lin CW3, Chang YS4. Molecules. 2014 Jul 4;19(7):9515-34. doi: 10.3390/molecules19079515.


Traditional Chinese medicinal herbs combined with epidermal growth factor receptor tyrosine kinase inhibitor for advanced non-small cell lung cancer: a systematic review and meta-analysis. Liu ZL1, Zhu WR2, et al. J Integr Med. 2014 Jul;12(4):346-58. doi: 10.1016/S2095-4964(14)60034-0.


Changing Physician Incentives for Affordable, Quality Cancer Care: Results of an Episode Payment Model.Newcomer LN1, Gould B2, Page RD2, Donelan SA2, Perkins M2. J Oncol Pract. 2014 Jul 8. pii: JOP.2014.001488. [Epub ahead of print]


Is Previous Respiratory Disease a Risk Factor for Lung Cancer?Denholm R1, Schüz J, Straif K, et al. Am J Respir Crit Care Med. 2014 Jul 23. [Epub ahead of print]


Public attitudes about lung cancer: stigma, support, and predictors of support. Weiss J1, Stephenson BJ2, Edwards LJ2, Rigney M3, Copeland A3. J Multidiscip Healthc. 2014 Jul 16;7:293-300. doi: 10.2147/JMDH.S65153. eCollection 2014.


Lung cancer trends: smoking, obesity, and sex assessed in the Staten Island University’s lung cancer patients.Gupta S1, Hassan S1, Bhatt VR2, Abdul Sater H1, Dilawari A3. Int J Gen Med. 2014 Jul 2;7:333-7. doi: 10.2147/IJGM.S55806. eCollection 2014.


Menopausal Hormone Therapy and Lung Cancer-Specific Mortality Following Diagnosis: The California Teachers Study.Clague J1, Reynolds P2, Henderson KD1, et al. PLoS One. 2014 Jul 31;9(7):e103735. doi: 10.1371/journal.pone.0103735. eCollection 2014.

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