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Monthly Pubmed Review

Monthly Pubmed Review of the Most Relevant Research on Lung Cancer
Literature Review, November 2014


Variations of chromosomes 2 and 3 gene expression profiles among pulmonary telocytes, pneumocytes, airway cells, mesenchymal stem cells and lymphocytes.Zheng M1, Sun X, Zhang M, et al. J Cell Mol Med. 2014 Oct;18(10):2044-60. doi: 10.1111/jcmm.12429. Epub 2014 Oct 2.

Circulating Angiogenesis Biomarkers Are Associated With Disease Progression in Lung Adeno-carcinoma. Daly S1, Kubasiak JC1, Rinewalt D1, et al. Ann Thorac Surg. 2014 Oct 6. pii: S0003-4975(14)01432-5. doi: 10.1016/j.athoracsur.2014.06.071. [Epub ahead of print]

Selective Anticancer Activity of Neurotoxin 1-Methyl-4-Phenylpyridinium on Non-small Cell Lung Adenocarcinoma A549 Cells. Badisa RB1, Mina DA2, Latinwo LM3, Soliman KF2. Anticancer Res. 2014 Oct;34(10):5447-52.

 Ouabain mediates integrin switch in human lung cancer cells. Ninsontia C1, Chanvorachote P2. Anticancer Res. 2014 Oct;34(10):5495-502

Functional consequences of somatic mutations in cancer using protein pocket-based prioritization approach.Vuong H1, Cheng F1, Lin CC1, Zhao Z2. Genome Med. 2014 Oct 14;6(10):81. doi: 10.1186/s13073-014-0081-7. eCollection 2014.

Estrogen receptor 1 gene expression and its combination with estrogen receptor 2 or aromatase expression predicts survival in non-small cell lung cancer.Aresti U1, Carrera S2, Iruarrizaga E2, et al. PLoS One. 2014 Oct 13;9(10):e109659. doi: 10.1371/journal.pone.0109659. eCollection 2014.

MicroRNA expression profiles associated with acquired gefitinib resistance in human lung adenocarcinoma cells. Ge X1, Zheng L2, Huang M3, Wang Y2, Bi F1. Mol Med Rep. 2015 Jan;11(1):333-40. doi: 10.3892/mmr.2014.2757. Epub 2014 Oct 23.

Chemopreventive effect of phosphodieasterase-4 inhibition in benzo(a)pyrene-induced murine lung cancer model. Yeo CD1, Kim JW, Ha JH, Kim SJ, Lee SH, Kim IK, Kim YK. Exp Lung Res. 2014 Dec;40(10):500-6. doi: 10.3109/01902148.2014.950769. Epub 2014 Oct 2.


Molecular testing for selection of patients with lung cancer for epidermal growth factor receptor and anaplastic lymphoma kinase tyrosine kinase inhibitors: American Society of Clinical Oncology endorsement of the College of American Pathologists/International Association for the Study of Lung Cancer/Association for Molecular Pathology Guideline. Leighl NB, Rekhtman N, Biermann WA, ET AL. J Clin Oncol. 2014 Nov 10;32(32):3673-9. doi: 10.1200/JCO.2014.57.3055. Epub 2014 Oct 13.

Components Necessary for High Quality Lung Cancer Screening: American College of Chest Physicians and American Thoracic Society Policy Statement. Mazzone P, Powell CA, Arenberg D, et al. Chest. 2014 Oct 30. doi: 10.1378/chest.14-2500. [Epub ahead of print]

Validation of the new IASLC/ATS/ERS lung adenocarcinoma classification: a surgeon’s perspective.Rocco R, Jones DR, Morabito A, Franco R, La Mantia E, Rocco G. J Thorac Dis. 2014 Oct;6(Suppl 5):S547-51. doi: 10.3978/j.issn.2072-1439.2014.06.43.

The ability of bilirubin in identifying smokers with higher risk of lung cancer: a large cohort study in conjunction with global metabolomic profiling. Wen CP1, Zhang F2, Liang D3, et al. Clin Cancer Res. 2014 Oct 21. pii: clincanres.0748.2014. [Epub ahead of print]

Projected outcomes using different nodule sizes to define a positive CT lung cancer screening examination. Gierada DS1, Pinsky P2, Nath H2, Chiles C2, Duan F2, Aberle DR2. J Natl Cancer Inst. 2014 Oct 18;106(11). pii: dju284. doi: 10.1093/jnci/dju284. Print 2014 Nov.

Clinicopathologic features and outcomes of patients with lung adenocarcinomas harboring BRAF mutations in the Lung Cancer Mutation Consortium. Villaruz LC1, Socinski MA, Abberbock S, et al. Cancer. 2014 Oct 1. doi: 10.1002/cncr.29042. [Epub ahead of print]

Patient reported experiences of CT guided lung biopsy: a prospective cohort study.Winn N1, Spratt J2, Wright E3, Cox J4. Multidiscip Respir Med. 2014 Oct 31;9(1):53. doi: 10.1186/2049-6958-9-53. eCollection 2014.

Biomarker testing for breast, lung, and gastroesophageal cancers at NCI designated cancer centers. Schink JC1, Trosman JR2, Weldon CB2, et al. J Natl Cancer Inst. 2014 Sep 12;106(10). pii: dju256. doi: 10.1093/jnci/dju256. Print 2014 Oct.

Prognostic Value of Metastatic N1 Lymph Node Ratio and Angiolymphatic Invasion in Patients With Pathologic Stage IIA Non-Small Cell Lung Cancer.Wu CF1, Wu CY, Fu JY, Wang CW, Liu YH, Hsieh MJ, Wu YC. Medicine (Baltimore). 2014 Oct;93(20):e102. doi: 10.1097/MD.0000000000000102.

Lung cancer probability in patients with CT-detected pulmonary nodules: a prespecified analysis of data from the NELSON trial of low-dose CT screening.Horeweg N1, van Rosmalen J2, Heuvelmans MA3, et al. Lancet Oncol. 2014 Oct 1. pii: S1470-2045(14)70389-4. doi: 10.1016/S1470-2045(14)70389-4. [Epub ahead of print]

Quantifying the expression of tumor marker genes in lung squamous cell cancer with RNA sequencing. Wang L, Zhan C, Zhang Y, Ma J, Xi J, Jiang W, Shi Y, Wang Q. J Thorac Dis. 2014 Oct;6(10):1380-7. doi: 10.3978/j.issn.2072-1439.2014.08.27.




Evaluation of tumor localization in respiration motion-corrected cone-beam CT: Prospective study in lung. Dzyubak O1, Kincaid R1, Hertanto A1, et al. Med Phys. 2014 Oct;41(10):101918. doi: 10.1118/1.4896101.

Re-evaluation of the role of post-operative radiotherapy and the impact of radiation dose for non-small cell lung cancer using the National Cancer Database. Corso CD1, Rutter CE, Wilson LD, Kim AW, Decker RH, Husain ZA. J Thorac Oncol. 2014 Oct 16. [Epub ahead of print]

Phase Ib study evaluating a self-adjuvanted mRNA cancer vaccine (RNActive®) combined with local radiation as consolidation and maintenance treatment for patients with stage IV non-small cell lung cancer. Sebastian M, Papachristofilou A, Weiss C, et al. BMC Cancer. 2014 Oct 6;14:748. doi: 10.1186/1471-2407-14-748.

Treatment-related acute esophagitis for patients with locoregionally advanced non-small cell lung cancer treated with involved-field radiotherapy and concurrent chemotherapy.Bar-Ad V1, Leiby B, Witek M, et al. Am J Clin Oncol. 2014 Oct;37(5):433-7. doi: 10.1097/COC.0b013e31827de7a2.

Stereotactic body radiation therapy for stage I non-small cell lung cancer: a small academic hospital experience.Factor OB1, Vu CC2, Schneider JG3, et al. Front Oncol. 2014 Oct 20;4:287. doi: 10.3389/fonc.2014.00287. eCollection 2014.

Local Control and Toxicity in a Large Cohort of Central Lung Tumors Treated With Stereotactic Body Radiation Therapy. Modh A1, Rimner A1, Williams E2, et al. Int J Radiat Oncol Biol Phys. 2014 Oct 8. pii: S0360-3016(14)03657-8. doi: 10.1016/j.ijrobp.2014.08.008. [Epub ahead of print]

Neutrophil-lymphocyte and platelet-lymphocyte ratios as prognostic factors following stereotactic radiation therapy for early-stage non-small cell lung cancer. Cannon NA1, Meyer J, Iyengar P, Ahn C, Westover KD, Choy H, Timmerman R. J Thorac Oncol. 2014 Oct 8. [Epub ahead of print]

SOCCAR: A randomised phase II trial comparing sequential versus concurrent chemotherapy and radical hypofractionated radiotherapy in patients with inoperable stage III Non-Small Cell Lung Cancer and good performance status. Maguire J1, Khan I2, McMenemin R3, O’Rourke N4, McNee S4, Kelly V5, Peedell C6, Snee M7. Eur J Cancer. 2014 Oct 7. pii: S0959-8049(14)00809-0. doi: 10.1016/j.ejca.2014.07.009. [Epub ahead of print]



Small cell lung carcinoma: staging, imaging, and treatment considerations.Carter BW1, Glisson BS, Truong MT, Erasmus JJ. Radiographics. 2014 Oct;34(6):1707-21. doi: 10.1148/rg.346140178.

Specific expression of OATPs in primary small cell lung cancer (SCLC) cells as novel biomarkers for diagnosis and therapy. Brenner S1, Klameth L2, Riha J1, et al. Cancer Lett. 2014 Oct 6. pii: S0304-3835(14)00552-7. doi: 10.1016/j.canlet.2014.09.025. [Epub ahead of print]

A multicenter pilot study examining the role of circulating tumor cells as a blood-based tumor marker in patients with extensive small-cell lung cancer.Huang CH1, Wick JA2, Sittampalam GS3, et al. Front Oncol. 2014 Oct 14;4:271. doi: 10.3389/fonc.2014.00271. eCollection 2014.

Bolstering the case for lobectomy in stage I, II and IIIA small cell lung cancer using the National Cancer Data Base. Combs SE1, Hancock JG, Boffa DJ, Decker RH, Detterbeck FC, Kim AW. J Thorac Oncol. 2014 Oct 14. [Epub ahead of print]

MET and Small-Cell Lung Cancer. Gelsomino F1, Rossi G2, Tiseo M3. Cancers (Basel). 2014 Oct 13;6(4):2100-15. doi: 10.3390/cancers6042100.


Worried together: a qualitative study of shared anxiety in patients with metastatic non-small cell lung cancer and their family caregivers.Hendriksen E1, Williams E, Sporn N, Greer J, DeGrange A, Koopman C. Support Care Cancer. 2014 Oct 3. [Epub ahead of print]

Survivorship care planning and its influence on long-term patient-reported outcomes among colorectal and lung cancer survivors: the CanCORS disease-free survivor follow-up study. Chrischilles EA1, McDowell BD, Rubenstein L, Charlton M, Pendergast J, Juarez GY, Arora NK. J Cancer Surviv. 2014 Oct 30. [Epub ahead of print]

Is progression-free survival associated with a better health-related quality of life in patients with lung cancer? Evidence from two randomised trials with afatinib. Griebsch I1, Palmer M2, Fayers PM3, Ellis S4. BMJ Open. 2014 Oct 31;4(10):e005762. doi: 10.1136/bmjopen-2014-005762.

Therapeutic Bronchoscopy for Malignant Central Airway Obstruction: Success Rates and Impact on Dyspnea and Quality of Life. Ost DE, Ernst A, Grosu HB, et al. Chest. 2014 Oct 30. doi: 10.1378/chest.14-1526. [Epub ahead of print]

Supportive care in lung cancer: Milestones over the past 40 years. Molassiotis A1, Uyterlinde W, Hollen PJ, Sarna L, Palmer P, Krishnasamy M. J Thorac Oncol. 2014 Oct 16. [Epub ahead of print]

Association of opioid requirement and cancer pain with survival in advanced non-small cell lung cancer. Zylla D1, Kuskowski MA2, Gupta K3, Gupta P4. Br J Anaesth. 2014 Oct 10. pii: aeu351. [Epub ahead of print]

Shame, guilt, and communication in lung cancer patients and their partners. Dirkse D1, Lamont L2, Li Y2, Simonič A3, Bebb G4, Giese-Davis J5. Curr Oncol. 2014 Oct;21(5):e718-22. doi: 10.3747/co.21.2034.

Experiences of Patients With Advanced Lung Cancer: Being Resigned to Sleep-Wake Disturbances While Maintaining Hope for Optimal Treatment Outcomes. Dickerson SS1, Abbu Sabbah E, Gothard S, et al. Cancer Nurs. 2014 Oct 6. [Epub ahead of print]

High-intensity training following lung cancer surgery: a randomised controlled trial. Edvardsen E1, Skjønsberg OH2, Holme I3, Nordsletten L4, Borchsenius F5, Anderssen SA3. Thorax. 2014 Oct 16. pii: thoraxjnl-2014-205944. doi: 10.1136/thoraxjnl-2014-205944. [Epub ahead of print]



Anticancer Studies of Aqueous Extract of Roots and Leaves of Pandanus Odoratissimus f. ferreus (Y. Kimura) Hatus: An In Vitro Approach.Raj GG1, Varghese HS2, Kotagiri S3, et al. J Tradit Complement Med. 2014 Oct;4(4):279-84. doi: 10.4103/2225-4110.129199.

Comparison of Efficacy and Toxicity of Traditional Chinese Medicine (TCM) Herbal Mixture LQ and Conventional Chemotherapy on Lung Cancer Metastasis and Survival in Mouse Models. Zhang L1, Wu C2, Zhang Y3, Liu F4, Wang X3, Zhao M3, Hoffman RM1. PLoS One. 2014 Oct 6;9(10):e109814. doi: 10.1371/journal.pone.0109814. eCollection 2014.

Antitumor effect of traditional Chinese herbal medicines against lung cancer. Chen Y1, Zhu J, Zhang W. Anticancer Drugs. 2014 Oct;25(9):983-91. doi: 10.1097/CAD.0000000000000127.


Discussions about clinical trials among patients with newly diagnosed lung and colorectal cancer. Kehl KL1, Arora NK1, Schrag D1, et al. J Natl Cancer Inst. 2014 Sep 13;106(10). pii: dju216. doi: 10.1093/jnci/dju216. Print 2014 Oct.

Immunotherapy for Lung Cancer: Has it Finally Arrived?Mostafa AA, Morris DG. Front Oncol. 2014 Oct 22;4:288. doi: 10.3389/fonc.2014.00288. eCollection 2014.

Aggressiveness of intensive care use among patients with lung cancer in the surveillance, epidemiology, and end results-medicare registry. Cooke CR, Feemster LC, Wiener RS, O’Neil ME, Slatore CG. Chest. 2014 Oct 1;146(4):916-23. doi: 10.1378/chest.14-0477.

Active and passive smoking in relation to lung cancer incidence in the Women’s Health Initiative Observational Study prospective cohort. Wang A1, Kubo J2, Luo J3, et al. Ann Oncol. 2014 Oct 14. pii: mdu470. [Epub ahead of print]

Decreasing Trend in Tobacco-Related Cancer Incidence, United States 2005-2009. Underwood JM1, Richards TB, Henley SJ, Momin B, Houston K, Rolle I, Holmes C, Stewart SL. J Community Health. 2014 Oct 10. [Epub ahead of print]

The mediation of social influences on smoking cessation and awareness of the early signs of lung cancer. Chatwin J1, Povey A, Kennedy A, Frank T, Firth A, Booton R, Barber P, Sanders C. BMC Public Health. 2014 Oct 7;14:1043. doi: 10.1186/1471-2458-14-1043.

Cognitive and Brain Structural Changes in Lung Cancer Population. Simó M1, Root JC, Vaquero L, et al. J Thorac Oncol. 2014 Oct 16. [Epub ahead of print]

The role of posttraumatic growth and timing of quitting smoking as moderators of the relationship between stigma and psychological distress among lung cancer survivors who are former smokers. Shen MJ1, Coups EJ, Li Y, Holland JC, Hamann HA, Ostroff JS. Psychooncology. 2014 Oct 27. doi: 10.1002/pon.3711. [Epub ahead of print]

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