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Monthly Pubmed Review

Monthly Pubmed Review of the Most Relevant Research on Lung Cancer
Literature Review, November 2015



SOX2 expression is associated with FGFR fusion genes and predicts favorable outcome in lung squamous cell carcinomas. Zheng S1, Pan Y1, Wang R1, et al. Onco Targets Ther. 2015 Oct 19;8:3009-16. doi: 10.2147/OTT.S91293. eCollection 2015.

Somatic Mutation Spectrum of Non-Small-Cell Lung Cancer in African Americans: A Pooled Analysis. Araujo LH1, Lammers PE, Matthews-Smith V, et al. J Thorac Oncol. 2015 Oct;10(10):1430-6. doi: 10.1097/JTO.0000000000000650.

Multiple Endocrine Disruption by the MET/ALK Inhibitor Crizotinib in Patients With Non-small Cell Lung Cancer. Sargis RM1, Salgia R. Am J Clin Oncol. 2015 Oct;38(5):442-7. doi: 10.1097/COC.0b013e3182a46896.

Vitamin A depletion induced by cigarette smoke is associated with an increase in lung cancer-related markers in rats. Xue Y1, Harris E2, Wang W3, Baybutt RC4,5. J Biomed Sci. 2015 Oct 14;22(1):84. doi: 10.1186/s12929-015-0189-0.

Elevated expression of ASCL2 is an independent prognostic indicator in lung squamous cell carcinoma. Hu XG1, Chen L1, Wang QL1, et al. J Clin Pathol. 2015 Oct 19. pii: jclinpath-2015-203025. doi: 10.1136/jclinpath-2015-203025. [Epub ahead of print]


Gaps in Guideline-Concordant Use of Diagnostic Tests Among Lung Cancer Patients. Flanagan MR1, Varghese TK Jr2, Backhus LM2, Wood DE2, Mulligan MS2, Cheng AM2, Flum DR1, Farjah F3. Ann Thorac Surg. 2015 Oct 24. pii: S0003-4975(15)01371-5. doi: 10.1016/j.athoracsur.2015.08.010. [Epub ahead of print]

Lung CT Screening Reporting and Data System Speed and Accuracy Are Increased With the Use of a Semiautomated Computer Application. Clark TJ1, Flood TF2, Maximin ST3, Sachs PB2. J Am Coll Radiol. 2015 Oct 22. pii: S1546-1440(15)00688-2. doi: 10.1016/j.jacr.2015.07.015. [Epub ahead of print]

CT Perfusion Characteristics Identify Metastatic Sites in Liver. Wang Y1, Hobbs BP1, Ng CS2. Biomed Res Int. 2015;2015:120749. doi: 10.1155/2015/120749. Epub 2015 Oct 5.

Lung Cancer Risk and Demographic Characteristics of Current 20-29 Pack-year Smokers: Implications for Screening. Pinsky PF1, Kramer BS2. J Natl Cancer Inst. 2015 Oct 19;107(11). pii: djv226. doi: 10.1093/jnci/djv226. Print 2015 Nov.

Evaluation of a Personalized, Web-Based Decision Aid for Lung Cancer Screening. Lau YK1, Caverly TJ2, Cao P1, Cherng ST1, West M1, Gaber C1, Arenberg D3, Meza R4. Am J Prev Med. 2015 Oct 8. pii: S0749-3797(15)00418-3. doi: 10.1016/j.amepre.2015.07.027. [Epub ahead of print]

Endobronchial Ultrasound-guided Transvascular Needle Aspiration: A Single-Center Experience. Panchabhai TS1, Machuzak MS, Sethi S, et al. J Bronchology Interv Pulmonol. 2015 Oct;22(4):306-11. doi: 10.1097/LBR.0000000000000227.

Local respiratory motion correction for PET/CT imaging: Application to lung cancer. Lamare F1, Fayad H2, Fernandez P1, Visvikis D2. Med Phys. 2015 Oct;42(10):5903. doi: 10.1118/1.4930251.

Planned FDG PET-CT Scan in Follow-Up Detects Disease Progression in Patients With Locally Advanced NSCLC Receiving Curative Chemoradiotherapy Earlier Than Standard CT. Pan Y1, Brink C, Schytte T, Petersen H, Wu YL, Hansen O. Medicine (Baltimore). 2015 Oct;94(43):e1863. doi: 10.1097/MD.0000000000001863.

JOURNAL CLUB: Standardizing CT-Guided Biopsy Procedures: Patient Dose and Image Noise.

Tam AL1, Ensor JE2, Zvavanjanja RC1,3, Philip A3, Abdelsalam ME1, Huang SY1, Gupta S1, Jones AK4. AJR Am J Roentgenol. 2015 Oct;205(4):W390-9. doi: 10.2214/AJR.14.13324.


The impact of tumor size on the association of the extent of lymph node resection and survival in clinical stage I non-small cell lung cancer. Gulack BC1, Yang CJ1, Speicher PJ1, et al. Lung Cancer. 2015 Oct 14. pii: S0169-5002(15)30080-5. doi: 10.1016/j.lungcan.2015.10.011. [Epub ahead of print]

Radiologic Characteristics of Surgically Resected Non-Small Cell Lung Cancer With ALK Rearrangement or EGFR Mutations. Kim TJ1, Lee CT2, Jheon SH3, Park JS4, Chung JH5. Ann Thorac Surg. 2015 Oct 8. pii: S0003-4975(15)01270-9. doi: 10.1016/j.athoracsur.2015.07.062. [Epub ahead of print]

Long-term Outcomes of Thoracoscopic Anatomic Resections and Systematic Lymphadenectomy for Elderly High-risk Patients with Stage IB Non-small-cell Lung Cancer. Fang Z1, He J2, Fang W3, Ruan L3, Fang F3. Heart Lung Circ. 2015 Oct 8. pii: S1443-9506(15)01396-7. doi: 10.1016/j.hlc.2015.08.022. [Epub ahead of print]

Predictors of Recurrence after Curative Resection in Patients with Early-Stage Non-Small Cell Lung Cancer. Lee SH1, Jo EJ2, Eom JS2, et al. Tuberc Respir Dis (Seoul). 2015 Oct;78(4):341-8. doi: 10.4046/trd.2015.78.4.341. Epub 2015 Oct 1.

Survival Benefit of Surgery after Chemoradiotherapy for Stage III (N0-2) Non-Small-Cell Lung Cancer Is Dependent on Pathologic Nodal Response. Ziel E1, Hermann G, Sen N, Bonomi P, Liptay MJ, Fidler MJ, Batus M, Warren WH, Chmielewski G, Sher DJ. J Thorac Oncol. 2015 Oct;10(10):1475-80. doi: 10.1097/JTO.0000000000000639.

Safety and Immunogenicity of MAGE-A3 Cancer Immunotherapeutic with or without Adjuvant Chemotherapy in Patients with Resected Stage IB to III MAGE-A3-Positive Non-Small-Cell Lung Cancer. Pujol JL1, Vansteenkiste JF, De Pas TM, et al. J Thorac Oncol. 2015 Oct;10(10):1458-67. doi: 10.1097/JTO.0000000000000653.


Randomized Adjuvant Chemotherapy of EGFR-Mutated Non-Small Cell Lung Cancer Patients with or without Icotinib Consolidation Therapy. Feng S1, Wang Y2, Cai K1, Wu H1, Xiong G1, Wang H1, Zhang Z1. PLoS One. 2015 Oct 16;10(10):e0140794. doi: 10.1371/journal.pone.0140794. eCollection 2015.

Feasibility study of docetaxel plus bevacizumab as first line therapy for elderly patients with advanced non-small-cell lung cancer: Thoracic Oncology Research Group (TORG) 1014. Takagi Y1, Hosomi Y2, Oshita F3, et al. BMC Cancer. 2015 Oct 19;15:740. doi: 10.1186/s12885-015-1756-1.

Effects of selenomethionine on acute toxicities from concurrent chemoradiation for inoperable stage III non-small cell lung cancer. Mix M1, Ramnath N1, Gomez J1, et al. World J Clin Oncol. 2015 Oct 10;6(5):156-65. doi: 10.5306/wjco.v6.i5.156.

Prognostic nutritional index before adjuvant chemotherapy predicts chemotherapy compliance and survival among patients with non-small-cell lung cancer. Shimizu K1, Okita R1, Saisho S1, Yukawa T1, Maeda A1, Nojima Y1, Nakata M1. Ther Clin Risk Manag. 2015 Oct 8;11:1555-61. doi: 10.2147/TCRM.S92961. eCollection 2015.

Treatment of isolated mediastinal and hilar recurrence of lung cancer with bronchoscopic endobronchial ultrasound guided intratumoral injection of chemotherapy with cisplatin. Mehta HJ1, Begnaud A2, Penley AM3, et al. Lung Cancer. 2015 Oct 9. pii: S0169-5002(15)30078-7. doi: 10.1016/j.lungcan.2015.10.009. [Epub ahead of print]

Locally Advanced Non-Small Cell Lung Cancer: Optimal Chemotherapeutic Agents and Duration. Mamdani H1, Jalal SI, Hanna N. Curr Treat Options Oncol. 2015 Oct;16(10):47. doi: 10.1007/s11864-015-0364-2.

Association of MDR1 Gene (C3435T) Polymorphism and Gene Expression Profiling in Lung Cancer Patients Treated with Platinum-Based Chemotherapy. Subhani S1, Jamil K2, Nirni SS3. Mol Diagn Ther. 2015 Oct;19(5):289-97. doi: 10.1007/s40291-015-0154-3.

Gender, Age, and Comorbidity Status Predict Improved Survival with Adjuvant Chemotherapy Following Lobectomy for Non-small Cell Lung Cancers Larger than 4 cm. Sandler BJ1, Wang Z2, Hancock JG3, Boffa DJ1, Detterbeck FC1, Kim AW4. Ann Surg Oncol. 2015 Oct 16. [Epub ahead of print]

Patterns and Predictors of Chemotherapy Use for Resected Non-Small Cell Lung Cancer. Rajaram R1, Paruch JL2, Mohanty S2, Holl JL3, Bilimoria KY4, Ko CY2, Winchester DP2, Patel JD5, DeCamp MM6. Ann Thorac Surg. 2015 Oct 24. pii: S0003-4975(15)01438-1. doi: 10.1016/j.athoracsur.2015.08.077. [Epub ahead of print]


Treatment Plan Technique and Quality for Single-Isocenter Stereotactic Ablative Radiotherapy of Multiple Lung Lesions with Volumetric-Modulated Arc Therapy or Intensity-Modulated Radiosurgery. Quan K1, Xu KM1, Lalonde R1, et al. Front Oncol. 2015 Oct 6;5:213. doi: 10.3389/fonc.2015.00213. eCollection 2015.

Simultaneously modulated accelerated radiation therapy reduces severe oesophageal toxicity in concomitant chemoradiotherapy of locally advanced non-small-cell lung cancer. Chajon E1, Bellec J1, Castelli J1, Corre R2, Kerjouan M2, Le Prisé E1, De Crevoisier R1,3. Br J Radiol. 2015 Oct 16:20150311. [Epub ahead of print]

Changing practice patterns of Gamma Knife versus linear accelerator-based stereotactic radiosurgery for brain metastases in the US. Park HS1, Wang EH1, Rutter CE1, Corso CD1, Chiang VL1,2, Yu JB1. J Neurosurg. 2015 Oct 16:1-7. [Epub ahead of print]

Prognostic Value of Computed Tomography Texture Features in Non-Small Cell Lung Cancers Treated With Definitive Concomitant Chemoradiotherapy. Ahn SY1, Park CM, Park SJ, et a;/ Invest Radiol. 2015 Oct;50(10):719-25. doi: 10.1097/RLI.0000000000000174.

A Phase II Trial of Erlotinib and Concurrent Palliative Thoracic Radiation for Patients With Non-Small-Cell Lung Cancer. Swaminath A1, Wright JR2, Tsakiridis TK2, et al. Clin Lung Cancer. 2015 Oct 9. pii: S1525-7304(15)00240-5. doi: 10.1016/j.cllc.2015.09.008. [Epub ahead of print]

Association Between Radiation Dose and Outcomes With Postoperative Radiotherapy for N0-N1 Non-Small Cell Lung Cancer. Wang EH1, Corso CD, Park HS, Chen AB, Wilson LD, Kim AW, Decker RH, Yu JB. Am J Clin Oncol. 2015 Oct 29. [Epub ahead of print]



The Integration of Multimodality Care for the Treatment of Small Cell Lung Cancer in a Rural Population and Its Impact on Survival. Lee K1, Kloecker G, Pan J, Rai S, Dunlap NE. Am J Clin Oncol. 2015 Oct;38(5):448-56. doi: 10.1097/COC.0b013e3182a5346d.

Prognostic Significance of CT-Determined Sarcopenia in Patients with Small-Cell Lung Cancer. Kim EY1, Kim YS, Park I, Ahn HK, Cho EK, Jeong YM. J Thorac Oncol. 2015 Oct 16. [Epub ahead of print]

Role of Chemoradiotherapy in Elderly Patients With Limited-Stage Small-Cell Lung Cancer. Corso CD1, Rutter CE1, Park HS1, Lester-Coll NH1, Kim AW1, Wilson LD1, Husain ZA1, Lilenbaum RC1, Yu JB1, Decker RH2. J Clin Oncol. 2015 Oct 19. pii: JCO.2015.62.4270. [Epub ahead of print]

When is surgery indicated for small-cell lung cancer? Veronesi G1, Bottoni E2, Finocchiaro G3, Alloisio M2. Lung Cancer. 2015 Oct 17. pii: S0169-5002(15)30086-6. doi: 10.1016/j.lungcan.2015.10.019. [Epub ahead of print]


Does the Primary Care Experience Influence the Cancer Diagnostic Process? Provost S1, Pineault R2, Tousignant P3, et al. Int J Family Med. 2015;2015:176812. doi: 10.1155/2015/176812. Epub 2015 Oct 4.

Pain Intensity and Pain Interference in Patients With Lung Cancer: A Pilot Study of Biopsychosocial Predictors. Dalton JA1, Higgins MK, Miller AH, Keefe FJ, Khuri FR. Am J Clin Oncol. 2015 Oct;38(5):457-64. doi: 10.1097/COC.0b013e3182a79009.

Social factors in informal cancer caregivers: The interrelationships among social stressors, relationship quality, and family functioning in the CanCORS data set. Litzelman K1, Kent EE1, Rowland JH1. Cancer. 2015 Oct 19. doi: 10.1002/cncr.29741. [Epub ahead of print]

Racial Disparities in Health-Related Quality of Life After Lung Cancer Surgery: Findings From the Cancer Care Outcomes Research and Surveillance Consortium. Poghosyan H1, Stock S, Kennedy Sheldon L, Cromwell J, Cooley ME, Nerenz DR. J Thorac Oncol. 2015 Oct;10(10):1404-12. doi: 10.1097/JTO.0000000000000629.

Pathways to a lung cancer diagnosis. Carter-Harris L1, Hermann CP2, Draucker CB1. J Am Assoc Nurse Pract. 2015 Oct;27(10):576-83. doi: 10.1002/2327-6924.12242. Epub 2015 Mar 12.

Survival in Patients With Severe Lymphopenia Following Treatment With Radiation and Chemotherapy for Newly Diagnosed Solid Tumors. Grossman SA1, Ellsworth S1, Campian J1, et al. J Natl Compr Canc Netw. 2015 Oct;13(10):1225-31.

Sharing news of a lung cancer diagnosis with adult family members and friends: a qualitative study to inform a supportive intervention. Ewing G1, Ngwenya N2, Benson J3, Gilligan D4, Bailey S5, Seymour J6, Farquhar M3. Patient Educ Couns. 2015 Oct 9. pii: S0738-3991(15)30080-X. doi: 10.1016/j.pec.2015.09.013. [Epub ahead of print]

Management of Dermatologic Complications of Lung Cancer Therapies. Pugliese SB1, Neal JW, Kwong BY. Curr Treat Options Oncol. 2015 Oct;16(10):50. doi: 10.1007/s11864-015-0368-y.

Impact of an Interactive On-line Tool on Therapeutic Decision-Making for Patients with Advanced Non-Small-Cell Lung Cancer. Chow H1, Edelman MJ, Giaccone G, et al. J Thorac Oncol. 2015 Oct;10(10):1421-9. doi: 10.1097/JTO.0000000000000508.


Ancient Chinese Formula Qiong-Yu-Gao Protects Against Cisplatin-Induced Nephrotoxicity Without Reducing Anti-tumor Activity. Teng ZY1,2, Cheng XL1,2, et al. Sci Rep. 2015 Oct 29;5:15592. doi: 10.1038/srep15592.

Traditional chinese patent medicines for cancer treatment in china: a nationwide medical insurance data analysis. Wu M1, Lu P2, Shi L1, Li S3. Oncotarget. 2015 Oct 13. doi: 10.18632/oncotarget.5711. [Epub ahead of print]


Current and future treatment of anaplastic lymphoma kinase-rearranged cancer. Mologni L1. World J Clin Oncol. 2015 Oct 10;6(5):104-8. doi: 10.5306/wjco.v6.i5.104.

Use of Dieselized Farm Equipment and Incident Lung Cancer: Findings from the Agricultural Health Study Cohort. Tual S1,2,3, Silverman DT, Koutros S, Blair A, Sandler DP, Lebailly P, Andreotti G, Hoppin JA, Beane Freeman LE. Environ Health Perspect. 2015 Oct 9. [Epub ahead of print]

Risk Adjusting Survival Outcomes in Hospitals That Treat Patients With Cancer Without Information on Cancer Stage. Pfister DG1, Rubin DM1, Elkin EB1, Neill US1, Duck E1, Radzyner M1, Bach PB1. JAMA Oncol. 2015 Oct 8:1-8. doi: 10.1001/jamaoncol.2015.3151. [Epub ahead of print]

A Prognostic Model to Predict Mortality among Non-Small Cell Lung Cancer Patients in the U.S. Military Health System. Lin J1, Carter CA, McGlynn KA, et al. J Thorac Oncol. 2015 Oct 15. [Epub ahead of print]

Impact of Multidisciplinary Care on Processes of Cancer Care: A Multi-Institutional Study. Onukwugha E1, Petrelli NJ2, Castro KM2, et al. J Oncol Pract. 2015 Oct 13. pii: JOP.2015.004200. [Epub ahead of print]

Patient’s lung cancer diagnosis as a cue for relatives’ smoking cessation: evaluating the constructs of the teachable moment. McBride CM1, Blocklin M2, Lipkus IM3, Klein WM4,5, Brandon TH6. Psychooncology. 2015 Oct 30. doi: 10.1002/pon.4011. [Epub ahead of print]


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