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LUNG CANCER PROGRAM


Monthly Pubmed Review

Monthly Pubmed Review of the Most Relevant Research on Lung Cancer
Literature Review,  August 2016

 

BASIC AND APPLIED SCIENCE, PRE-CLINICAL STUDIES

Prognostic significance of circulating laminin gamma2 for early-stage non-small-cell lung cancer. Teng Y1, Wang Z2, Ma L1, et al. Onco Targets Ther. 2016 Jul 7;9:4151-62. doi: 10.2147/OTT.S105732. eCollection 2016.

Differential expression and significance of PD-L1, IDO-1 and B7-H4 in human lung cancer. Schalper KA1, Carvajal-Hausdorf D2, McLaughlin J3, Altan M4, Velcheti V5, Gaule P2, Sanmamed MF6, Chen L7, Herbst RS8, Rimm DL2. Clin Cancer Res. 2016 Jul 20. pii: clincanres.0150.2016. [Epub ahead of print]

High Specificity in Circulating Tumor Cell Identification Is Required for Accurate Evaluation of Programmed Death-Ligand 1. Schehr JL1, Schultz ZD1, Warrick JW2, et al. PLoS One. 2016 Jul 26;11(7):e0159397. doi: 10.1371/journal.pone.0159397. eCollection 2016.

Glypican-5 is a tumor suppressor in non-small cell lung cancer cells. Guo L1, Wang J1, Zhang T1, Yang Y2. Biochem Biophys Rep. 2016 Jul;6:108-112.

CLINICAL TRIALS, COHORT STUDIES, PILOT STUDIES – NSCLC – CHEMOTHERAPY

Predictive factors for a long-term response duration in non-squamous cell lung cancer patients treated with pemetrexed. Park S1, Kim HJ2, Choi CM1,3, et al. BMC Cancer. 2016 Jul 7;16:417. doi: 10.1186/s12885-016-2457-0.

Multicenter Phase II Study of Whole-Body and Intracranial Activity With Ceritinib in Patients With ALK-Rearranged Non-Small-Cell Lung Cancer Previously Treated With Chemotherapy and Crizotinib: Results From ASCEND-2. Crinò L1, Ahn MJ2, De Marinis F2, et al. J Clin Oncol. 2016 Jul 18. pii: JCO655936. [Epub ahead of print]

FDA Approval: Alectinib for the Treatment of Metastatic ALK-Positive Non-Small Cell Lung Cancer Following Crizotinib. Larkins E1, Blumenthal GM2, Chen H3, et al. Clin Cancer Res. 2016 Jul 13. pii: clincanres.1293.2016. [Epub ahead of print]

Brief Report: An Open-Label, Multicenter, Randomized, Phase II Study of Cisplatin and Pemetrexed With or Without Cixutumumab (IMC-A12) as a First-Line Therapy in Patients With Advanced Nonsquamous Non-Small Cell Lung Cancer. Novello S1, Scagliotti G2, de Castro G Jr3, et al. J Thorac Oncol. 2016 Jul 24. pii: S1556-0864(16)30631-1. doi: 10.1016/j.jtho.2016.07.013. [Epub ahead of print]

Chemotherapy in elderly patients with nonsmall cell lung cancer. Veluswamy RR1, Levy B, Wisnivesky JP. Curr Opin Pulm Med. 2016 Jul;22(4):336-43. doi: 10.1097/MCP.0000000000000286.

A multicenter phase II trial of S-1 combined with bevacizumab after platinum-based chemotherapy in patients with advanced non-squamous non-small cell lung cancer. Yamada K1, Ichiki M2, Takahashi K3, et al. Cancer Chemother Pharmacol. 2016 Jul 11. [Epub ahead of print]

CLINICAL TRIALS, COHORT STUDIES, PILOT STUDIES – NSCLC – IMMUNOTHERAPY

CLINICAL TRIALS, COHORT STUDIES, PILOT STUDIES – NSCLC – OTHER

CLINICAL TRIALS, COHORT STUDIES, PILOT STUDIES – NSCLC – RADIOTHERAPY

Regional Lung Function Profiles of Stage I and III Lung Cancer Patients: An Evaluation for Functional Avoidance Radiation Therapy. Vinogradskiy Y1, Schubert L2, Diot Q2, et al. Int J Radiat Oncol Biol Phys. 2016 Jul 15;95(4):1273-80. doi: 10.1016/j.ijrobp.2016.02.058.

Long-Term Survival after Radiofrequency Ablation of Lung Oligometastases from Five Types of Primary Lesions: A Retrospective Evaluation. Omae K1, Hiraki T2, Gobara H1, Iguchi T1, Fujiwara H1, Matsui Y1, Toyooka S3, Nagasaka T4, Kanazawa S1. J Vasc Interv Radiol. 2016 Jul 22. pii: S1051-0443(16)30168-3. doi: 10.1016/j.jvir.2016.05.017. [Epub ahead of print]

Stereotactic Body Radiation Therapy for Stage I Non-Small Cell Lung Cancer: A Retrospective, Single-Center Study of 55 Patients. Bhandari RP1, Stanford JD, Packianathan S, et al. Oncology. 2016 Jul 19. [Epub ahead of print]

The effect of non-small cell lung cancer histology on survival as measured by the graded prognostic assessment in patients with brain metastases treated by hypofractionated stereotactic radiotherapy. Ma LH1, Li G2, Zhang HW1, et al. Radiat Oncol. 2016 Jul 13;11(1):92. doi: 10.1186/s13014-016-0667-x.

CLINICAL TRIALS, COHORT STUDIES, PILOT STUDIES – NSCLC – SURGERY

Long term survival with stereotactic ablative radiotherapy (SABR) versus thoracoscopic sublobar lung resection in elderly people: national population based study with propensity matched comparative analysis. Paul S1, Lee PC2, Mao J3, Isaacs AJ3, Sedrakyan A4. BMJ. 2016 Jul 8;354:i3570. doi: 10.1136/bmj.i3570.

Surgery for non-small cell lung cancer in patients with a history of cardiovascular surgery. Maeda H1, Kanzaki M2, Sakamoto K1, Isaka T1, Yamazaki K3, Onuki T1. Surg Today. 2016 Jul 21. [Epub ahead of print]

Socioeconomic Factors Are Associated With Readmission After Lobectomy for Early Stage Lung Cancer. Medbery RL1, Gillespie TW2, Liu Y3, Nickleach DC4, Lipscomb J5, Sancheti MS1, Pickens A1, Force SD1, Fernandez FG6. Ann Thorac Surg. 2016 Jul 28. pii: S0003-4975(16)30555-0. doi: 10.1016/j.athoracsur.2016.05.060. [Epub ahead of print]

CLINICAL TRIALS, COHORT STUDIES, PILOT STUDIES – SMALL CELL LUNG CANCER (SCLC)

An orthotopic mouse model of small cell lung cancer reflects the clinical course in patients. Taromi S1, Kayser G2, von Elverfeldt D3, et al. Clin Exp Metastasis. 2016 Jul 6. [Epub ahead of print]

WW domain binding protein 5 induces multidrug resistance of small cell lung cancer under the regulation of miR-335 through the Hippo pathway. Tang R1, Lei Y1,2, Hu B1, Yang J1, Fang S1, Wang Q1, Li M1, Guo L1. Br J Cancer. 2016 Jul 12;115(2):243-51. doi: 10.1038/bjc.2016.186. Epub 2016 Jun 23.

PARP Inhibitor Activity Correlates with SLFN11 Expression and Demonstrates Synergy with Temozolomide in Small Cell Lung Cancer. Lok BH1, Gardner EE2, Schneeberger VE3, et al. Clin Cancer Res. 2016 Jul 20. pii: clincanres.1040.2016. [Epub ahead of print]

Prophylactic cranial irradiation in small cell lung cancer: A single institution experience. Nicholls L1, Keir GJ1, Murphy MA1, Mai T1, Lehman M1. Asia Pac J Clin Oncol. 2016 Jul 25. doi: 10.1111/ajco.12564. [Epub ahead of print]

Phase III Randomized Trial of Ipilimumab Plus Etoposide and Platinum Versus Placebo Plus Etoposide and Platinum in Extensive-Stage Small-Cell Lung Cancer. Reck M1, Luft A2, Szczesna A2, et al. J Clin Oncol. 2016 Jul 25. pii: JCO676601. [Epub ahead of print]

Impact of thoracic radiotherapy timing in limited-stage small-cell lung cancer: usefulness of the individual patient data meta-analysis. De Ruysscher D1, Lueza B2, Le Péchoux C3, et al. Ann Oncol. 2016 Jul 19. pii: mdw263. [Epub ahead of print]

Tumor infiltrating lymphocytes and PD-L1 expression in brain metastases of small cell lung cancer (SCLC). Berghoff AS1,2, Ricken G2,3, Wilhelm D4, Rajky O1,2, Widhalm 3,5, Dieckmann K2,6, Birner P2,7, Bartsch R1,2, Preusser M8,9. J Neurooncol. 2016 Jul 19. [Epub ahead of print]

COMPLEMENTARY & ALTERNATIVE THERAPY

MISCELLANEOUS WORKS

Associations of Insulin and IGFBP-3 with Lung Cancer Susceptibility in Current Smokers. Ho GY1, Zheng SL2, Cushman M2, et al. J Natl Cancer Inst. 2016 Apr 12;108(7). pii: djw012. doi: 10.1093/jnci/djw012. Print 2016 Jul.

Radon, Secondhand Smoke, and Children in the Home: Creating a Teachable Moment for Lung Cancer Prevention. Huntington-Moskos L1, Rayens MK2, Wiggins A2, Hahn EJ2. Public Health Nurs. 2016 Jul 22. doi: 10.1111/phn.12283. [Epub ahead of print]

Five-Year Survival Among Stage IIIA Lung Cancer Patients Receiving Two Different Treatment Modalities. Bilfinger T1, Keresztes R2, Albano D1, Nemesure B3. Med Sci Monit. 2016 Jul 21;22:2589-94.

Physical activity and sedentary behavior in relation to lung cancer incidence and mortality in older women: The Women’s Health Initiative. Wang A1, Qin F2, Hedlin H2, et al. Int J Cancer. 2016 Jul 20. doi: 10.1002/ijc.30281. [Epub ahead of print]

PALLIATIVE AND SUPPORTIVE CARE

Palliative Care Specialist Consultation Is Associated with Supportive Care Quality in Advanced Cancer. Walling AM1, Tisnado D2, Ettner SL3, et al. J Pain Symptom Manage. 2016 Jul 8. pii: S0885-3924(16)30167-1. doi: 10.1016/j.jpainsymman.2016.04.005. [Epub ahead of print]

The Association of Chemotherapy-Induced Peripheral Neuropathy Symptoms and the Risk of Falling. Kolb NA1, Smith AG1, Singleton JR1, Beck SL2, Stoddard GJ3, Brown S1, Mooney K2. JAMA Neurol. 2016 Jul 1;73(7):860-6. doi: 10.1001/jamaneurol.2016.0383.

POSITIVE study: physical exercise program in non-operable lung cancer patients undergoing palliative treatment. Wiskemann J1,2, Hummler S3,4,5, Diepold C6, et al. BMC Cancer. 2016 Jul 19;16(1):499. doi: 10.1186/s12885-016-2561-1.

Characteristics of patients with advanced lung cancer referred to a rapid-access supportive care clinic. Yennurajalingam S1, Lu Z1, Williams JL1, Liu DD2, Arthur JA1, Bruera E1. Palliat Support Care. 2016 Jul 22:1-8. [Epub ahead of print]

Analgesic effectiveness and tolerability of oral oxycodone/naloxone and pregabalin in patients with lung cancer and neuropathic pain: an observational analysis. De Santis S1, Borghesi C1, Ricciardi S2, et al. Onco Targets Ther. 2016 Jul 4;9:4043-52. doi: 10.2147/OTT.S108144. eCollection 2016.

Assessment of anxiety in advanced cancer patients: a mixed methods study. Veldhuisen H1, Zweers D2, de Graaf E2, Teunissen S3. Int J Palliat Nurs. 2016 Jul 2;22(7):341-50. doi: 10.12968/ijpn.2016.22.7.341.

Randomized Pilot Trial of a Telephone Symptom Management Intervention for Symptomatic Lung Cancer Patients and Their Family Caregivers. Mosher CE1, Winger JG2, Hanna N3, et al. J Pain Symptom Manage. 2016 Jul 8. pii: S0885-3924(16)30173-7. doi: 10.1016/j.jpainsymman.2016.04.006. [Epub ahead of print]

Toxicity-Related Factors Associated With Use of Services Among Community Oncology Patients. Harrison JM1, Stella PJ2, LaVasseur B2, Adams PT2, Swafford L2, Lewis J2, Mendelsohn-Victor K2, Friese CR2. J Oncol Pract. 2016 Jul 12. pii: JOPR010959. [Epub ahead of print]

Espindolol for the treatment and prevention of cachexia in patients with stage III/IV non-small cell lung cancer or colorectal cancer: a randomized, double-blind, placebo-controlled, international multicentre phase II study (the ACT-ONE trial). Stewart Coats AJ1, Ho GF2, Prabhash K3, von Haehling S4, Tilson J5, Brown R5, Beadle J5, Anker SD4; for and on behalf of the ACT‐ONE study group. J Cachexia Sarcopenia Muscle. 2016 Jun;7(3):355-65. doi: 10.1002/jcsm.12126. Epub 2016 Jul 1.

SCREENING, DIAGNOSIS AND STAGING

Factors Associated with a Positive Baseline Screening Exam Result in the National Lung Screening Trial. Balekian AA1, Tanner NT2,3, Fisher JM4, Silvestri GA5, Gould MK6. Ann Am Thorac Soc. 2016 Jul 7. [Epub ahead of print]

Does Lymph Node Count Influence Survival in Surgically Resected Non-Small Cell Lung Cancer? David EA1, Cooke DT2, Chen Y3, Nijar K4, Canter RJ5, Cress RD6. Ann Thorac Surg. 2016 Jul 25. pii: S0003-4975(16)30500-8. doi: 10.1016/j.athoracsur.2016.05.018. [Epub ahead of print]

Limits and potential of targeted sequencing analysis of liquid biopsy in patients with lung and colon carcinoma. Rachiglio AM1, Abate RE1, Sacco A1, et al. Oncotarget. 2016 Jul 19. doi: 10.18632/oncotarget.10704. [Epub ahead of print]

PET/CT-guided percutaneous biopsy of FDG-avid metastatic bone lesions in patients with advanced lung cancer: a safe and effective technique. Guo W1, Hao B1, Chen HJ1, Zhao L1, Luo ZM1, Wu H1, Sun L2. Eur J Nucl Med Mol Imaging. 2016 Jul 22. [Epub ahead of print]

The five commandments of efficient and effective care in the initial evaluation of lung cancer. Chang CF1, Gould MK. Curr Opin Pulm Med. 2016 Jul;22(4):319-26. doi: 10.1097/MCP.0000000000000281.

The impact on the prognosis of unsuspected N2 disease in non-small-cell lung cancer: indications for thorough mediastinal staging in the modern era. Tachi R1, Hattori A1, Matsunaga T1, Takamochi K1, Oh S1, Suzuki K2. Surg Today. 2016 Jul 21. [Epub ahead of print]

Risk Factors for Predicting Occult Lymph Node Metastasis in Patients with Clinical Stage I Non-small Cell Lung Cancer Staged by Integrated Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography. Kaseda K1, Asakura K2, Kazama A3, Ozawa Y4. World J Surg. 2016 Jul 25. [Epub ahead of print]

Use of Positron Emission Tomography to Detect Recurrence and Associations With Survival in Patients With Lung and Esophageal Cancers. Healy MA1, Yin H2, Reddy RM2, Wong SL2. J Natl Cancer Inst. 2016 Feb 22;108(7). pii: djv429. doi: 10.1093/jnci/djv429. Print 2016 Jul.

Clinical Utility of Liquid Diagnostic Platforms in Non-Small Cell Lung Cancer. Levy B1, Hu ZI2, Cordova KN3, Close S4, Lee K2, Becker D5. Oncologist. 2016 Jul 7. pii: theoncologist.2016-0082. [Epub ahead of print]

Readiness for Implementation of Lung Cancer Screening: A National Survey of VA Pulmonologists. Tukey MH1, Clark JA2,3, Bolton R4, et al. Ann Am Thorac Soc. 2016 Jul 13. [Epub ahead of print]

Endobronchial Ultrasound Guided Transbronchial Needle Aspiration for Mediastinal Staging in a Community Medical Center. Warren WA1, Hagaman JT2. Ann Am Thorac Soc. 2016 Jul 13. [Epub ahead of print]

Predicting malignant nodules from screening CTs. Hawkins S1, Wang H2, Liu Y2, et al. J Thorac Oncol. 2016 Jul 12. pii: S1556-0864(16)30600-1. doi: 10.1016/j.jtho.2016.07.002. [Epub ahead of print]

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