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Monthly Pubmed Review

Monthly Pubmed Review of the Most Relevant Research on Lung Cancer
Literature Review, September 2014


A signaling pathway consisting of miR-551b, catalase and MUC1 contributes to acquired apoptosis resistance and chemoresistance.Xu X1, Wells A1, Padilla MT1, Kato K2, Kim KC2, Lin Y3. Carcinogenesis. 2014 Aug 1. pii: bgu159. [Epub ahead of print]

Unmethylation of the CHRNB4 gene is an unfavorable prognostic factor in non-small cell lung cancer.Yoo SS1, Lee SM2, Do SK1, Lee WK3, Kim DS4, Park JY5. Lung Cancer. 2014 Aug 12. pii: S0169-5002(14)00324-9. doi: 10.1016/j.lungcan.2014.08.002. [Epub ahead of print]

Sensitive methods for detection of the S768R substitution in exon 18 of the DDR2 gene in patients with central nervous system metastases of non-small cell lung cancer.Nicoś M1, Powrózek T, Krawczyk P, et al. Med Oncol. 2014 Oct;31(10):176. doi: 10.1007/s12032-014-0176-4. Epub 2014 Aug 31.

Anti-MET immunoPET for non-small cell lung cancer using fully human antibody fragments. Li K1, Tavare R1, Zettlitz KA1, et al. Mol Cancer Ther. 2014 Aug 20. pii: molcanther.0363.2014. [Epub ahead of print]

Prolongation of overall survival in advanced lung adenocarcinoma patients with the XAGE1 (GAGED2a) antibody. Ohue Y1, Kurose K1, Mizote Y2, et al. Clin Cancer Res. 2014 Aug 14. pii: clincanres.0742.2014. [Epub ahead of print]

Novel Carbazole Inhibits Phospho-STAT3 through Induction of Protein-Tyrosine Phosphatase PTPN6.Hou S1, Yi YW, Kang HJ, et al. J Med Chem. 2014 Aug 14;57(15):6342-53. doi: 10.1021/jm4018042. Epub 2014 Aug 4.

SIRT1 Inactivation Evokes Antitumor Activities in NSCLC through the Tumor Suppressor p27. Zhu L1, Chiao CY1, Enzer KG1, Stankiewicz AJ2, Faller DV1, Dai Y3. Mol Cancer Res. 2014 Aug 20. pii: molcanres.0239.2014. [Epub ahead of print]


Resource Utilization and Costs during the Initial Years of Lung Cancer Screening with Computed Tomography in Canada.Cressman S1, Lam S, Tammemagi MC, et al. J Thorac Oncol. 2014 Aug 7. [Epub ahead of print]


Experience With a CT Screening Program for Individuals at High Risk for Developing Lung Cancer.McKee BJ1, Hashim JA2, French RJ2, et al. J Am Coll Radiol. 2014 Aug 28. pii: S1546-1440(14)00470-0. doi: 10.1016/j.jacr.2014.08.002. [Epub ahead of print]


Predicting Lung Cancer Prior to Surgical Resection in Patients with Lung Nodules.Deppen SA1, Blume JD, Aldrich MC, et al. J Thorac Oncol. 2014 Aug 28. [Epub ahead of print]


Rebiopsy during disease progression in patients treated by TKI for oncogene-addicted NSCLC. Bosc C1, Ferretti GR, Cadranel J, et al. Target Oncol. 2014 Aug 15. [Epub ahead of print]


Cytology specimens offer an effective alternative to formalin-fixed tissue as demonstrated by novel automated detection for ALK break-apart FISH testing and immunohistochemistry in lung adenocarcinoma.Rosenblum F1, Hutchinson LM, Garver J, Woda B, Cosar E, Kurian EM. Cancer Cytopathol. 2014 Aug 5. doi: 10.1002/cncy.21467. [Epub ahead of print]


Sensitive Genotyping of Somatic Mutations in the EGFR, KRAS, PIK3CA, BRAF Genes from NSCLC Patients Using Hydrogel Biochips.Emelyanova M1, Arkhipova K, Mazurenko N, et al. Appl Immunohistochem Mol Morphol. 2014 Aug 22. [Epub ahead of print]


Endobronchial Ultrasound Elastography in the Diagnosis of Mediastinal and Hilar Lymph Nodes. Izumo T1, Sasada S2, Chavez C2, Matsumoto Y2, Tsuchida T2. Jpn J Clin Oncol. 2014 Aug 13. pii: hyu105. [Epub ahead of print]


Clinical challenges in targeting anaplastic lymphoma kinase in advanced non-small cell lung cancer.

Vijayvergia N1, Mehra R. Cancer Chemother Pharmacol. 2014 Sep;74(3):437-46. doi: 10.1007/s00280-014-2517-6. Epub 2014 Aug 19.


A Phase II, Open-Label Study of Ramucirumab in Combination with Paclitaxel and Carboplatin as First-Line Therapy in Patients with Stage IIIB/IV Non-Small-Cell Lung Cancer.Camidge DR1, Berge EM, Doebele RC, et al. J Thorac Oncol. 2014 Aug 28. [Epub ahead of print]


Thoracoscopic Left Upper Lobectomy in Patients With Internal Mammary Artery Coronary Bypass Grafts.Shah AA1, Worni M1, Onaitis MW1, et al. Ann Thorac Surg. 2014 Aug 7. pii: S0003-4975(14)01250-8. doi: 10.1016/j.athoracsur.2014.05.068. [Epub ahead of print]


Metastatic index of non-small-cell lung cancer and long-term survival.Poullis M1, Shackcloth M2, Page R2, Asanti-Siaw J2, Woolley S2, Mediratta N2. Asian Cardiovasc Thorac Ann. 2014 Aug 7. pii: 0218492314545833. [Epub ahead of print]


Trimodality Therapy for Lung Cancer With Chest Wall Invasion: Initial Results of a Phase II Study.Kawaguchi K1, Yokoi K2, Niwa H3, et al. Ann Thorac Surg. 2014 Aug 7. pii: S0003-4975(14)01073-X. doi: 10.1016/j.athoracsur.2014.05.022. [Epub ahead of print]


Prognostic factors affecting survival of patients with cancer-related pericardial effusion managed by surgery.Jeon HW, Cho DG, Park JK, Hyun KY, Choi SY, Suh JH, Kim YD1. World J Surg Oncol. 2014 Aug 5;12(1):249. doi: 10.1186/1477-7819-12-249.


Cross-sectional Survey on Lobectomy Approach (X-SOLA).Cao C, Tian DH, Wolak K, Oparka J, He J, Dunning J, Walker WS, Yan TD. Chest. 2014 Aug 1;146(2):292-8. doi: 10.1378/chest.13-1075.


Characteristics of Benign Solitary Pulmonary Nodules Confirmed by Diagnostic Video-Assisted Thoracoscopic Surgery.Sun Mi C1, Eun Young H, Lee J, et al. Clin Respir J. 2014 Aug 8. doi: 10.1111/crj.12200. [Epub ahead of print]


Validation of a scoring system to predict recurrence of resected solitary fibrous tumors of the pleura.Tapias LF, Mercier O, Ghigna MR, et al. Chest. 2014 Aug 7. doi: 10.1378/chest.14-1180. [Epub


Smoking is a perioperative risk factor and prognostic factor for lung cancer surgery.Shiono S1, Katahira M, Abiko M, Sato T. Gen Thorac Cardiovasc Surg. 2014 Aug 2. [Epub ahead of print]


Pulmonary function after lobectomy versus segmentectomy in patients with stage I non-small cell lung cancer.Saito H1, Nakagawa T, Ito M, Imai K, Ono T, Minamiya Y. World J Surg. 2014 Aug;38(8):2025-31. doi: 10.1007/s00268-014-2521-3.


Pulmonary function after lobectomy versus segmentectomy in patients with stage I non-small cell lung cancer.Saito H1, Nakagawa T, Ito M, Imai K, Ono T, Minamiya Y. World J Surg. 2014 Aug;38(8):2025-31. doi: 10.1007/s00268-014-2521-3.


OPN Polymorphism Is Related to the Chemotherapy Response and Prognosis in Advanced NSCLC. Hao Y1, Liu J2, Wang P3, Wang F1, Yu Z1, Li M1, Chen S1, Ning F1. Int J Genomics. 2014;2014:846142. doi: 10.1155/2014/846142. Epub 2014 Aug 5.

A phase II randomized study evaluating the addition of iniparib to gemcitabine plus cisplatin as first-line therapy for metastatic non-small cell lung cancer.Novello S1, Besse B2, Felip E3, et al. Ann Oncol. 2014 Aug 19. pii: mdu384. [Epub ahead of print]


Efficacy of motesanib diphosphate in non-small-cell lung cancer. Rijavec E1, Genova C, Barletta G, et al. Expert Opin Pharmacother. 2014 Aug;15(12):1771-80. doi: 10.1517/14656566.2014.938639.


NCCTG N0821 (Alliance): A Phase II First-Line Study of Pemetrexed, Carboplatin, and Bevacizumab in Elderly Patients with Advanced Nonsquamous Non-Small-Cell Lung Cancer With Good Performance Status. Dy GK1, Molina JR, Qi Y, et al. J Thorac Oncol. 2014 Aug;9(8):1146-53. doi: 10.1097/JTO.0000000000000217.


Frontline Systemic Therapy With Pemetrexed-Platinum in Nonsquamous Non-Small-Cell Lung Cancer With Asymptomatic Brain Metastases.Alsidawi S1, Chaudhary R, Karim NA. Am J Ther. 2014 Aug 22. [Epub ahead of print]


Personalized dose selection in radiation therapy using statistical models for toxicity and efficacy with dose and biomarkers as covariates.Schipper MJ1, Taylor JM, TenHaken R, Matuzak MM, Kong FM, Lawrence TS. Stat Med. 2014 Aug 27. doi: 10.1002/sim.6285. [Epub ahead of print]


Stereotactic Body Radiation Therapy for Unbiopsied Early-stage Lung Cancer: A Multi-Institutional Analysis.Harkenrider MM1, Bertke MH, Dunlap NE. Am J Clin Oncol. 2014 Aug;37(4):337-42. doi: 10.1097/COC.0b013e318277d822.


Dosimetric factors associated with weight loss during (chemo)radiotherapy treatment for lung cancer.Kiss N1, Krishnasamy M1, Everitt S2, Gough K3, Duffy M4, Isenring E5. Eur J Clin Nutr. 2014 Aug 13. doi: 10.1038/ejcn.2014.166. [Epub ahead of print]


Optimal beam arrangement for pulmonary ventilation image-guided intensity-modulated radiotherapy for lung cancer.Wang R, Zhang S1, Yu H, Lin S, Zhang G, Tang R, Qi B. Radiat Oncol. 2014 Aug 16;9:184. doi: 10.1186/1748-717X-9-184.


Stereotactic Ablative Radiotherapy for Pulmonary Oligometastases and Oligometastatic Lung Cancer.Shultz DB1, Filippi AR, Thariat J, Mornex F, Loo BW Jr, Ricardi U. J Thorac Oncol. 2014 Aug 28. [Epub ahead of print]


On the validity of density overrides for VMAT lung SBRT planning.Wiant D, Vanderstraeten C, Maurer J, Pursley J, Terrell J, Sintay BJ. Med Phys. 2014 Aug;41(8):081707. doi: 10.1118/1.4887778.


Emergence of Stereotactic Body Radiation Therapy and Its Impact on Current and Future Clinical Practice.Timmerman RD1, Herman J2, Cho LC2. J Clin Oncol. 2014 Aug 11. pii: JCO.2014.55.4675. [Epub ahead of print]


Radiobiologic comparison of helical tomotherapy, intensity modulated radiotherapy, and conformal radiotherapy in treating lung cancer accounting for secondary malignancy risks.Komisopoulos G1, Mavroidis P2, Rodriguez S3, et al. Med Dosim. 2014 Aug 25. pii: S0958-3947(14)00076-4. doi: 10.1016/j.meddos.2014.06.001. [Epub ahead of print]

Cisplatin vs. carboplatin-based chemoradiotherapy in patients >65years of age with stage III non-small cell lung cancer. Ezer N1, Smith CB2, Galsky MD3, et al. Radiother Oncol. 2014 Aug 20. pii: S0167-8140(14)00320-X. doi: 10.1016/j.radonc.2014.07.014. [Epub ahead of print]Mhango G4, Gu F5, Gomez J3, Strauss GM6, Wisnivesky J7.


Predictors of Early Recurrence for Node-Negative T1 to T2b Non-Small Cell Lung Cancer. Kiankhooy A1, Taylor MD1, LaPar DJ1, et al. Ann Thorac Surg. 2014 Aug 15. pii: S0003-4975(14)01181-3. doi: 10.1016/j.athoracsur.2014.05.061. [Epub ahead of print]


Differences in Patterns of Recurrence in Early-Stage Versus Locally Advanced Non-Small Cell Lung Cancer.Lou F1, Sima CS2, Rusch VW3, Jones DR3, Huang J4. Ann Thorac Surg. 2014 Aug 7. pii: S0003-4975(14)01268-5. doi: 10.1016/j.athoracsur.2014.05.070. [Epub ahead of print]


Is neoadjuvant chemotherapy mandatory for limited-disease small-cell lung cancer?Xu YJ1, Zheng H2, Gao W2, Jiang GN2, Xie HK3, Chen C4, Fei K4. Interact Cardiovasc Thorac Surg. 2014 Aug 24. pii: ivu262. [Epub ahead of print]


Surgery for small cell lung cancer: a retrospective analysis of 243 patients from Japanese lung cancer registry in 2004.Takei H1, Kondo H, Miyaoka E, et al. J Thorac Oncol. 2014 Aug;9(8):1140-5. doi: 10.1097/JTO.0000000000000226.


Adjuvant chemotherapy in patients with completely resected small cell lung cancer: a retrospective analysis of 26 consecutive cases.  Mizugaki H1, Fujiwara Y2, Yamamoto N1, et al. Jpn J Clin Oncol. 2014 Sep;44(9):835-40. doi: 10.1093/jjco/hyu092. Epub 2014 Aug 5.


Neuroendocrine Tumors of the Lung: The Role of Surgery in Small Cell Lung Cancer.Stamatis G. Thorac Surg Clin. 2014 Aug;24(3):313-326. doi: 10.1016/j.thorsurg.2014.05.004.


Unanticipated frequency and consequences of regimen-related diarrhea in patients being treated with radiation or chemoradiation regimens for cancers of the head and neck or lung. Sonis S1, Elting L, Keefe D, Nguyen H, Grunberg S, Randolph-Jackson P, Brennan M; on behalf of the TRIAD Burden of Illness Investigators. Support Care Cancer. 2014 Aug 16. [Epub ahead of print]


Effects of Walking on Quality of Life Among Lung Cancer Patients: A Longitudinal Study.Lin YY1, Liu MF, Tzeng JI, Lin CC. Cancer Nurs. 2014 Aug 2. [Epub ahead of print]


Socioeconomic Status Is Associated with Depressive Severity Among Patients with Advanced Non-Small-Cell Lung Cancer: Treatment Setting and Minority Status Do Not Make a Difference. Fagundes C1, Jones D, Vichaya E, Lu C, Cleeland CS. J Thorac Oncol. 2014 Aug 28. [Epub ahead of print]


Treatment priorities in oncology: do we want to live longer or better?Marta GN1, Del Nero LG1, Marta GN2, et al. Clinics (Sao Paulo). 2014 Aug;69(8):509-14.


Annona muricata leaves induced apoptosis in A549 cells through mitochondrial-mediated pathway and involvement of NF-kappaB. Zorofchian Moghadamtousi S, Abdul Kadir H, Paydar M, Rouhollahi E, Karimian H. BMC Complement Altern Med. 2014 Aug 15;14(1):299. [Epub ahead of print]


The possibility of traditional chinese medicine as maintenance therapy for advanced nonsmall cell lung cancer.Xu W, Yang G, Xu Y, et al. Evid Based Complement Alternat Med. 2014;2014:278917. doi: 10.1155/2014/278917. Epub 2014 Aug 4.


Cytotoxic and Nitric Oxide Production-Inhibitory Activities of Limonoids and Other Compounds from the Leaves and Bark of Melia azedarach.Pan X1, Matsumoto M, Nishimoto Y, et al. Chem Biodivers. 2014 Aug;11(8):1121-39. doi: 10.1002/cbdv.201400190.


In Vitro Antioxidant, Antibacterial, and Cytotoxic Activity and In Vivo Effect of Syngonium podophyllum and Eichhornia crassipes Leaf Extracts on Isoniazid Induced Oxidative Stress and Hepatic Markers.Kumar S, Kumar R, Dwivedi A, Pandey AK. Biomed Res Int. 2014;2014:459452. doi: 10.1155/2014/459452. Epub 2014 Aug 4.



Prevalence and Correlates of Smoking and Cessation-Related Behavior among Survivors of Ten Cancers: Findings from a Nationwide Survey Nine Years after Diagnosis.Westmaas JL1, Alcaraz KI2, Berg CJ3, Stein KD2. Cancer Epidemiol Biomarkers Prev. 2014 Sep;23(9):1783-92. doi: 10.1158/1055-9965.EPI-14-0046. Epub 2014 Aug 6.


Cancer Immunotherapy Highlights from the 2014 ASCO Meeting.Harshman LC1, Drake CG2, Wargo JA3, Sharma P4, Bhardwaj N5. Cancer Immunol Res. 2014 Aug;2(8):714-9. doi: 10.1158/2326-6066.CIR-14-0119.


Non-small cell lung cancer treatment receipt and survival among African-Americans and whites in a rural area.Hua X1, Ward KC, Gillespie TW, Lipscomb J, Goodman M. J Community Health. 2014 Aug;39(4):696-705. doi: 10.1007/s10900-013-9813-7.


Patterns in lung cancer incidence rates and trends by histologic type in the United States, 2004-2009.Houston KA1, Henley SJ2, Li J3, White MC4, Richards TB5. Lung Cancer. 2014 Aug 12. pii: S0169-5002(14)00323-7. doi: 10.1016/j.lungcan.2014.08.001. [Epub ahead of print]


US lung cancer trends by histologic type.Lewis DR1, Check DP, Caporaso NE, Travis WD, Devesa SS. Cancer. 2014 Aug 11:1-11. doi: 10.1002/cncr.28749. [Epub ahead of print]

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