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Monthly Pubmed Review

Monthly Pubmed Review of the Most Relevant Research on Lung Cancer
Literature Review, April 2015



No impact of passive smoke on the somatic profile of lung cancers in never-smokers. Couraud S1, Debieuvre D1, Moreau L1, et al. Eur Respir J. 2015 Mar 5. pii: ERJ-00973-2014. [Epub ahead of print]

PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations. Zou HY1, Li Q2, Engstrom LD2, et al. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3493-8. doi: 10.1073/pnas.1420785112. Epub 2015 Mar 2.

IL-24 Inhibits Lung Cancer Cell Migration and Invasion by Disrupting The SDF-1/CXCR4 Signaling Axis. Panneerselvam J1, Jin J2, Shanker M2, et al. PLoS One. 2015 Mar 16;10(3):e0122439. doi: 10.1371/journal.pone.0122439. eCollection 2015.

Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) oncogenic targets with a bifunctional inhibitor. Van Dort ME1, Galbán S2, Wang H3, et al. Bioorg Med Chem. 2015 Apr 1;23(7):1386-94. doi: 10.1016/j.bmc.2015.02.053. Epub 2015 Mar 6.

Tricetin, a dietary flavonoid, suppresses benzo(a)pyrene induced human non small cell lung cancer bone metastasis. Hung JY1, Chang WA2, et al. Int J Oncol. 2015 Mar 4. doi: 10.3892/ijo.2015.2915. [Epub ahead of print]



The Relations between False Positive and Negative Screens and Smoking Cessation and Relapse in the National Lung Cancer Screening Trial: Implications for Public Health. Clark MA1, Gorelick JJ2, Sicks JD2, Park ER3, Graham AL4, Abrams DB5, Gareen IF6. Nicotine Tob Res. 2015 Mar 6. pii: ntv037. [Epub ahead of print]

Small RNA Sequencing for Profiling MicroRNAs in Long-Term Preserved Formalin-Fixed and Paraffin-Embedded Non-Small Cell Lung Cancer Tumor Specimens. Buitrago DH1, Patnaik SK2, Kadota K3, Kannisto E2, Jones DR1, Adusumilli PS4. PLoS One. 2015 Mar 26;10(3):e0121521. doi: 10.1371/journal.pone.0121521.

FDG Uptake on Positron Emission Tomography Correlates with Survival and Time to Recurrence in Patients with Stage I Non-Small Cell Lung Cancer. Kwon W1, Howard BA, Herndon JE, Patz EF Jr. J Thorac Oncol. 2015 Mar 25. [Epub ahead of print]

Bronchoscopic transparenchymal nodule access (BTPNA): first in human trial of a novel procedure for sampling solitary pulmonary nodules. Herth FJ1, Eberhardt R1, Sterman D2, Silvestri GA3, Hoffmann H4, Shah PL5. Thorax. 2015 Apr;70(4):326-32. doi: 10.1136/thoraxjnl-2014-206211. Epub 2015 Mar 6.

MiR-205 and MiR-375 MicroRNA Assays to Distinguish Squamous Cell Carcinoma from Adenocarcinoma in Lung Cancer Biopsies. Patnaik S1, Mallick R, Kannisto E, Sharma R, Bshara W, Yendamuri S, Dhillon SS. J Thorac Oncol. 2015 Mar;10(3):446-53. doi: 10.1097/JTO.0000000000000423.

Intraoperative core needle biopsy under complete video-assisted thoracic surgery for indeterminate tumor of lung. Isaka T1, Takahashi K, Maehara T, Masuda M. Surg Endosc. 2015 Mar 5. [Epub ahead of print]

Endobronchial Ultrasound-guided Transbronchial Needle Aspiration for Systematic Nodal Staging of Lung Cancer in Patients with N0 Disease by Computed Tomography and Integrated Positron Emission Tomography-Computed Tomography. Ong P1, Grosu H, Eapen GA, et al. Ann Am Thorac Soc. 2015 Mar;12(3):415-9. doi: 10.1513/AnnalsATS.201409-429OC.


Uniportal video-assisted thoracoscopic lobectomy: an alternative to conventional thoracoscopic lobectomy in lung cancer surgery? Chung JH1, Choi YS2, Cho JH3, Kim HK3, Kim J3, Zo JI3, Shim YM3. Interact Cardiovasc Thorac Surg. 2015 Mar 3. pii: ivv034. [Epub ahead of print]

Minimally Invasive Resection of Early Lung Cancers. Cheng AM, Wood DE. Oncology (Williston Park). 2015 Mar 15;29(3). pii: 204255.

Efficacy and safety of stereotactic ablative radiotherapy in patients with previous pneumonectomy. Giaj Levra N1, Filippi AR, Guarneri A, Badellino S, Mantovani C, Ruffini E, Ricardi U. Tumori. 2015 Mar 11;0(0):0. doi: 10.5301/tj.5000227. [Epub ahead of print]


Three-arm, randomized, phase 2 study of carboplatin and paclitaxel in combination with cetuximab, cixutumumab, or both for advanced nonsmall cell lung cancer (NSCLC) patients who will not receive bevacizumab-based therapy: An Eastern Cooperative Oncology Group (ECOG) study (E4508). Hanna NH1, Dahlberg SE, Kolesar JM, et al. Cancer. 2015 Mar 4. doi: 10.1002/cncr.29308. [Epub ahead of print]

Modulation of NF-κB/miR-21/PTEN Pathway Sensitizes Non-Small Cell Lung Cancer to Cisplatin. Yang Z1, Fang S1, Di Y1, Ying W1, Tan Y1, Gu W1. PLoS One. 2015 Mar 23;10(3):e0121547. doi: 10.1371/journal.pone.0121547. eCollection 2015.

Switch maintenance treatment with oral vinorelbine and bevacizumab after induction chemotherapy with cisplatin, gemcitabine and bevacizumab in patients with advanced non-squamous non-small cell lung cancer: a phase II study. Petrioli R1, Francini E, Fiaschi AI, et al. Med Oncol. 2015 Apr;32(4):587. doi: 10.1007/s12032-015-0587-x. Epub 2015 Mar 22.

Adjuvant chemotherapy for resected early-stage non-small cell lung cancer. Burdett S1, Pignon JP, Tierney J, et al. Cochrane Database Syst Rev. 2015 Mar 2;3:CD011430. [Epub ahead of print]

Phase II Trial of Gefitinib in Combination with Bevacizumab as First-Line Therapy for Advanced Non-Small Cell Lung Cancer with Activating EGFR Gene Mutations: The Okayama Lung Cancer Study Group Trial 1001. Ichihara E1, Hotta K, Nogami N, et al. J Thorac Oncol. 2015 Mar;10(3):486-91. doi: 10.1097/JTO.0000000000000434.

Adjuvant Chemotherapy in Resected Stage II Non-small Cell Lung Cancer: Evaluating the Impact of Dose Intensity and Time to Treatment. Ramsden K1, Laskin J1, Ho C2. Clin Oncol (R Coll Radiol). 2015 Mar 19. pii: S0936-6555(15)00102-8. doi: 10.1016/j.clon.2015.03.001. [Epub ahead of print]

A randomized trial comparing adjuvant chemotherapy with gemcitabine plus cisplatin with docetaxel plus cisplatin in patients with completely resected non-small-cell lung cancer with quality of life as the primary objective. Barlesi F1, Chouaid C2, Crequit J3, et al. Interact Cardiovasc Thorac Surg. 2015 Mar 11. pii: ivv050. [Epub ahead of print]



Bayesian network models for error detection in radiotherapy plans. Kalet AM1, Gennari JH, Ford EC, Phillips MH. Phys Med Biol. 2015 Apr 7;60(7):2735-49. doi: 10.1088/0031-9155/60/7/2735. Epub 2015 Mar 13.

Safety and Palliative Efficacy of Single-Dose 8-Gy Reirradiation for Painful Local Failure in Patients With Stage IV Non-Small Cell Lung Cancer Previously Treated With Radical Chemoradiation Therapy. Topkan E1, Yildirim BA2, Guler OC2, Parlak C2, Pehlivan B3, Selek U4. Int J Radiat Oncol Biol Phys. 2015 Mar 15;91(4):774-80. doi: 10.1016/j.ijrobp.2014.12.010.

Intensity-modulated radiotherapy and volumetric-modulated arc therapy have distinct clinical advantages in non-small cell lung cancer treatment. Zhang J1, Yu XL, Zheng GF, Zhao F. Med Oncol. 2015 Apr;32(4):546. doi: 10.1007/s12032-015-0546-6. Epub 2015 Mar 1.



DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2. Poirier JT1, Gardner EE2, Connis N3, et al. Oncogene. 2015 Mar 9. doi: 10.1038/onc.2015.38. [Epub ahead of print]

Significance of programmed cell death-ligand 1 expression and its association with survival in patients with small cell lung cancer. Ishii H1, Azuma K, Kawahara A, et al. J Thorac Oncol. 2015 Mar;10(3):426-30. doi: 10.1097/JTO.0000000000000414.

Is stereotactic radiosurgery a rational treatment option for brain metastases from small cell lung cancer? A retrospective analysis of 70 consecutive patients. Yomo S1, Hayashi M. BMC Cancer. 2015;15(1):1103. doi: 10.1186/s12885-015-1103-6. Epub 2015 Mar 4.

Upregulation of the inwardly rectifying potassium channel Kir2.1 (KCNJ2) modulates multidrug resistance of small-cell lung cancer under the regulation of miR-7 and the Ras/MAPK pathway. Liu H1, Huang J, Peng J, Wu X, Zhang Y, Zhu W, Guo L. Mol Cancer. 2015 Dec;14(1):298. doi: 10.1186/s12943-015-0298-0. Epub 2015 Mar 12.

Chemotherapy With or Without Maintenance Sunitinib for Untreated Extensive-Stage Small-Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Phase II Study-CALGB 30504 (Alliance). Ready NE1, Pang HH2, Gu L2, et al.

Risk of hippocampal metastases in small cell lung cancer patients at presentation and after cranial irradiation: a safety profile study for hippocampal sparing during prophylactic or therapeutic cranial irradiation. Kundapur V1, Ellchuk T2, Ahmed S3, Gondi V4. Int J Radiat Oncol Biol Phys. 2015 Mar 15;91(4):781-6. doi: 10.1016/j.ijrobp.2014.12.026.

Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer. Blackhall F1. Ann Oncol. 2015 Mar;26 Suppl 2:ii15. doi: 10.1093/annonc/mdv089.5.



Concealment of lung cancer diagnosis: prevalence and correlates. Gonzalez BD1, Jim HS, Cessna JM, Small BJ, Sutton SK, Jacobsen PB. Psychooncology. 2015 Mar 9. doi: 10.1002/pon.3793. [Epub ahead of print]

Treatment Toxicity in Elderly Patients With Advanced Non-Small Cell Lung Cancer. Kale MS1, Mhango G, Gomez JE, Sigel K, Smith CB, Bonomi M, Wisnivesky JP. Am J Clin Oncol. 2015 Mar 13. [Epub ahead of print]

How do patients share news of a cancer diagnosis with family/friends; new understandings of the process after bad news has been broken. Ewing G1, Ngwenya N2, Farquhar M3, Benson J3, Gilligan D4, Seymour J5, Bailey S6. BMJ Support Palliat Care. 2015 Mar;5(1):114. doi: 10.1136/bmjspcare-2014-000838.32.

Perceptions of lung cancer and potential impacts on funding and patient care: a qualitative study. Tran K1, Delicaet K, Tang T, Ashley LB, Morra D, Abrams H. J Cancer Educ. 2015 Mar;30(1):62-7. doi: 10.1007/s13187-014-0677-z.

Palliative radiotherapy with or without additional care by a multidisciplinary palliative care team in patients with newly diagnosed cancer: a retrospective matched pairs comparison. Nieder C1, Dalhaug A, Pawinski A, Haukland E, Mannsåker B, Engljähringer K. Radiat Oncol. 2015 Dec;10(1):365. doi: 10.1186/s13014-015-0365-0. Epub 2015 Mar 7.

Minimal important difference of the 6-minute walk distance in lung cancer. Granger CL1, Holland AE2, Gordon IR3, Denehy L4. Chron Respir Dis. 2015 Mar 6. pii: 1479972315575715. [Epub ahead of print]

The Impact of a Multidimensional Exercise Intervention on Physical and Functional Capacity, Anxiety, and Depression in Patients With Advanced-Stage Lung Cancer Undergoing Chemotherapy. Quist M1, Adamsen L2, Rørth M3, Laursen JH3, Christensen KB2, Langer SW3. Integr Cancer Ther. 2015 Mar 22. pii: 1534735415572887. [Epub ahead of print]

What bothers lung cancer patients the most? A prospective, longitudinal electronic patient-reported outcomes study in advanced non-small cell lung cancer. LeBlanc TW1, Nickolich M, Rushing CN, Samsa GP, Locke SC, Abernethy AP. Support Care Cancer. 2015 Mar 21. [Epub ahead of print]


Comprehensive geriatric assessment and traditional Chinese medicine intervention benefit symptom control in elderly patients with advanced non-small cell lung cancer. Xue D1, Han S, Jiang S, et al. Med Oncol. 2015 Apr;32(4):563. doi: 10.1007/s12032-015-0563-5. Epub 2015 Mar 15.

Chemical components from the leaves of Ardisia insularis and their cytotoxic activity. Van NT1, Vien TA, Van Kiem P, et al. Arch Pharm Res. 2015 Mar 21. [Epub ahead of print]

Trichosanthes kirilowii Fruits Inhibit Non-Small Cell Lung Cancer Cell Growth Through Mitotic Cell-Cycle Arrest. Ni L1, Zhu X, Gong C, Luo Y, Wang L, Zhou W, Zhu S, Li Y. Am J Chin Med. 2015 Mar 17:1-16. [Epub ahead of print]


Lung cancer stigma as a barrier to medical help-seeking behavior: Practice implications. Carter-Harris L1. J Am Assoc Nurse Pract. 2015 Mar 3. doi: 10.1002/2327-6924.12227. [Epub ahead of print]

Exposure to secondhand tobacco smoke and the frailty syndrome in US older adults. García-Esquinas E1, Navas-Acien A, Rodríguez-Artalejo F. Age (Dordr). 2015 Apr;37(2):9762. doi: 10.1007/s11357-015-9762-4. Epub 2015 Mar 15.

Survival and Racial Differences of Non-Small Cell Lung Cancer in the United States Military. Brzezniak C1, Satram-Hoang S, Goertz HP, et al. J Gen Intern Med. 2015 Mar 25. [Epub ahead of print]

Improving Survival in Patients Treated for a Lung Cancer Using Self-Evaluated Symptoms Reported Through a Web Application. Denis F1, Yossi S, Septans AL, et al. Am J Clin Oncol. 2015 Mar 24. [Epub ahead of print]

Patient Perspectives and Preferences for Communication of Medical Imaging Risks in a Cancer Care Setting. Thornton RH1, Dauer LT, Shuk E, et al. Radiology. 2015 Mar 24:132905. [Epub ahead of print]

Nivolumab: targeting PD-1 to bolster antitumor immunity. Brahmer JR1, Hammers H, Lipson EJ. Future Oncol. 2015 Mar 23:0. [Epub ahead of print]

Perspectives of African Americans on Lung Cancer: A Qualitative Analysis. Lathan CS1, Waldman LT2, Browning E2, Gagne J2, Emmons K2. Oncologist. 2015 Mar 20. pii: theoncologist.2014-0399. [Epub ahead of print]

Pulmonologist Involvement, Stage-Specific Treatment, and Survival in Adults with Non-Small Cell Lung Cancer and COPD. Deepak JA1, Ng X, Feliciano J, Mao L, Davidoff AJ. Ann Am Thorac Soc. 2015 Mar 11. [Epub ahead of print]

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