PubMed Review

November 2021

PubMed Review of the Most relevant research on Lung Cancer

SCREENING, DIAGNOSIS, BIOMARKER TESTING, AND STAGING

Comorbidity Profiles and Lung Cancer Screening among Older Adults: U.S. Behavioral Risk Factor Surveillance System 2017-2019 Ann Am Thorac Soc. 2021 Nov;18(11):1886-1893. doi: 10.1513/AnnalsATS.202010-1276OC. Shailesh Advani1 2, Dongyu Zhang 3, Martin Tammemagi 4, et al.

Estimating the population health impact of a multi-cancer early detection genomic blood test to complement existing screening in the US and UK Br J Cancer. 2021 Nov;125(10):1432-1442. doi: 10.1038/s41416-021-01498-4. Epub 2021 Aug 23. Allan Hackshaw  1 , Sarah S Cohen  2 , Heidi Reichert  3 , Anuraag R Kansal  4 , Karen C Chung  4 , Joshua J Ofman  4

Lung cancer staging, the established role of bronchoscopy Curr Opin Pulm Med. 2021 Nov 1. doi: 10.1097/MCP.0000000000000843. Online ahead of print. Tanya Marshall  1 , Satish Kalanjeri, Francisco Aecio Almeida

Comparative clinical outcomes for patients with advanced NSCLC harboring EGFR exon 20 insertion mutations and common EGFR mutations Lung Cancer. 2021 Nov 6;162:154-161. doi: 10.1016/j.lungcan.2021.10.020. Online ahead of print. Lyudmila Bazhenova  1 , Anna Minchom  2 , Santiago Viteri  3 , et al.

Patient-centered Reporting in Radiology: A Single-site Survey Study of Lung Cancer Screening Results J Thorac Imaging. 2021 Nov 1;36(6):367-372. doi: 10.1097/RTI.0000000000000591. Spencer K Barrett  1 , James Patrie  1 , Andrea B Kitts  2 , Michael Hanley  1 , Christina M Swanson  1 , Hans Vitzthum von Eckstaedt  1 , Arun Krishnaraj

NSCLC SURGERY

A Prediction Model for Postoperative Pulmonary Complication in Pulmonary Function-Impaired Patients Following Lung Resection J Multidiscip Healthc. 2021 Nov 15;14:3187-3194. doi: 10.2147/JMDH.S327285. eCollection 2021. Xiaowei Mao #  1   2 , Wei Zhang #  1   3 , Yi-Qian Ni  1 , Yanjie Niu  1 , Li-Yan Jiang  1

The influence of tobacco load versus smoking status on outcomes following lobectomy for lung cancer in a statewide quality collaborative J Thorac Cardiovasc Surg. 2021 Nov;162(5):1375-1385.e1. doi: 10.1016/j.jtcvs.2020.10.162. Epub 2020 Dec 10. Riad H Al Natour  1 , Chang He  2 , Melissa J Clark  2 , Robert Welsh  3 , Andrew C Chang  4 , Kumari N Adams  5

Venous Thromboembolism in Surgical Lung Cancer Patients: A Provincial Population-Based Study Ann Thorac Surg. 2021 Nov 13;S0003-4975(21)01906-8. doi: 10.1016/j.athoracsur.2021.10.018. Online ahead of print. Gileh-Gol Akhtar-Danesh  1 , Noori Akhtar-Danesh  2 , Yaron Shargall  3

NSCLC – SYSTEMIC THERAPIES (CHEMOTHERAPY, TARGETED THERAPY, AND IMMUNOTHERAPY)

Impact of Checkpoint Inhibitor Immunotherapy, Primarily Pembrolizumab, on Infection Risk in Patients With Advanced Lung Cancer: A Comparative Retrospective Cohort Study Clin Infect Dis. 2021 Nov 2;73(9):e2697-e2704. doi: 10.1093/cid/ciaa802. Alexandre E Malek  1 , Melissa Khalil  1 , Ray Hachem  1 , et al.

Ensartinib vs Crizotinib for Patients With Anaplastic Lymphoma Kinase-Positive Non-Small Cell Lung Cancer: A Randomized Clinical Trial JAMA Oncol. 2021 Nov 1;7(11):1617-1625. doi: 10.1001/jamaoncol.2021.3523. Leora Horn  1   2 , Ziping Wang  3 , Gang Wu  4 , et al.

First-line osimertinib in elderly patients with epidermal growth factor receptor-mutated advanced non-small cell lung cancer: a retrospective multicenter study (HOT2002) Sci Rep. 2021 Nov 30;11(1):23140. doi: 10.1038/s41598-021-02561-z. Gaku Yamamoto  1 , Hajime Asahina  2 , Osamu Honjo  3 , et al.

Postoperative Chemotherapy Use and Outcomes From ADAURA: Osimertinib as Adjuvant Therapy for Resected EGFR-Mutated NSCLC J Thorac Oncol. 2021 Nov 2;S1556-0864(21)03285-8. doi: 10.1016/j.jtho.2021.10.014. Online ahead of print. Yi-Long Wu  1 , Thomas John  2 , Christian Grohe  3 , et al.

 

Technical Feasibility and Safety of Repeated Computed Tomography-Guided Transthoracic Intratumoral Injection of Gene-Modified Cellular Immunotherapy in Metastatic NSCLC JTO Clin Res Rep. 2021 Oct 14;2(11):100242. doi: 10.1016/j.jtocrr.2021.100242. eCollection 2021 Nov.

Puja Shahrouki  1 , Jay M Lee  2 , Jonathan Barclay  1 , Sarah N Khan  1 , Scott Genshaft  1 , Fereidoun Abtin  1 , Steven M Dubinett  3 , Aaron Lisberg  4 , Sherven Sharma 3, Edward B Garon  4, Robert Suh  1

 

Knowledge About Risks, Benefits, and Curative Potential of Immunotherapy Among Patients with Advanced Cancer Oncologist. 2021 Nov;26(11):e2090-e2093. doi: 10.1002/onco.13945. Epub 2021 Aug 28. Laura A Petrillo  1 , Ashley Z Zhou  1 , Ryan Sullivan  2 , Angelo Volandes  3   4 , Joseph A Greer 5 , Jennifer S Temel  2 , Areej El-Jawahri  2

 

A plain language summary of results from the ADAURA study: osimertinib after surgery for patients who have early-stage EGFR-mutated non-small cell lung cancer Future Oncol. 2021 Dec 1;17(35):4827-4835. doi: 10.2217/fon-2021-0752. Epub 2021 Nov 1. Yi-Long Wu  1 , Masahiro Tsuboi  2 , Thomas John  3 , et al.

 

Real-world efficacy and safety of anlotinib as third- or further-line treatment in refractory small cell lung cancer J Cancer Res Clin Oncol. 2021 Nov 8. doi: 10.1007/s00432-021-03848-4. Online ahead of print. Xuetian Gao  1 , Ling Peng  2 , Li Zhang  3, Kai Huang 4, Cuihua Yi  4 , Bei Li  4, Xue Meng 1, Jisheng Li  5

 

Comparative Effectiveness of Atezolizumab, Nivolumab, and Docetaxel in Patients With Previously Treated Non-Small Cell Lung Cancer JAMA Netw Open. 2021 Nov 1;4(11):e2134299. doi: 10.1001/jamanetworkopen.2021.34299. Sreeram Ramagopalan  1 , Alind Gupta  2 , Paul Arora  2 , Kristian Thorlund  2 , Joshua Ray  1 , Vivek Subbiah  3

 

Evorpacept alone and in combination with pembrolizumab or trastuzumab in patients with advanced solid tumours (ASPEN-01): a first-in-human, open-label, multicentre, phase 1 dose-escalation and dose-expansion study Lancet Oncol. 2021 Nov 15;S1470-2045(21)00584-2. doi: 10.1016/S1470-2045(21)00584-2. Online ahead of print. Nehal J Lakhani  1 , Laura Q M Chow  2 , Justin F Gainor  3 , et al.

NSCLC - RADIOTHERAPY

Radiation Pneumonitis After Volumetric Modulated Arc Therapy for Non-small Cell Lung Cancer Anticancer Res. 2021 Nov;41(11):5793-5802. doi: 10.21873/anticanres.15396. Masayuki Fujiwara  1 , Hiroshi Doi  2 , Masataka Igeta  3 , et al.

Hypofractionated Proton Beam Therapy for cT1-2N0M0 Non-small Cell Lung Cancer Patients With Interstitial Lung Disease Anticancer Res. 2021 Nov;41(11):5635-5642. doi: 10.21873/anticanres.15379. Takashi Saito  1 , Kayoko Ohnishi  2   3 , Hitoshi Ishikawa  1   4 , et al.

Clinically validated model predicts the effect of intratumoral heterogeneity on overall survival for non-small cell lung cancer (NSCLC) patients Comput Methods Programs Biomed. 2021 Nov;212:106455. doi: 10.1016/j.cmpb.2021.106455. Epub 2021 Oct 12. Nima Ghaderi  1 , Joseph H Jung  2 , David J Odde  3 , Jeffrey Peacock  4

Cost-Effectiveness of Carbon-Ion Radiotherapy versus Stereotactic Body Radiotherapy for Non-Small Cell Lung Cancer Cancer Sci. 2021 Nov 25. doi: 10.1111/cas.15216. Online ahead of print. Shohei Okazaki  1   2 , Kei Shibuya  1 , Tomoyuki Takura  3 , Yuhei Miyasaka  1 , Hidemasa Kawamura  2 , Tatsuya Ohno  1   2

Effect of brain radiotherapy strategies on prognosis of patients with EGFR-mutant lung adenocarcinoma with brain metastasis J Transl Med. 2021 Nov 30;19(1):486. doi: 10.1186/s12967-021-03161-1. Guangchuan Deng  1   2 , Yingyun Zhang  1   2 , Jiaojiao Ke  3 , Qi Wang  1   2 , Hongyue Qin  1   2 , Jianbin Li  4   5 , Zhenxiang Li  6

Implementation of a Knowledge-Based Treatment Planning Model for Cardiac-Sparing Lung Radiation Therapy Adv Radiat Oncol. 2021 Jun 24;6(6):100745. doi: 10.1016/j.adro.2021.100745. eCollection Nov-Dec 2021. Joseph Harms  1   2 , Jiahan Zhang  1 , Oluwatosin Kayode  1 , Jonathan Wolf  1 , Sibo Tian  1 , Neal McCall  1 , Kristin A Higgins  1 , Richard Castillo  1 , Xiaofeng Yang  1

Association Between Physician and Patient Reported Symptoms in Patients Treated with Definitive Radiotherapy for Locally Advanced Lung Cancer in a Statewide Consortium Int J Radiat Oncol Biol Phys. 2021 Nov 25;S0360-3016(21)03222-3. doi: 10.1016/j.ijrobp.2021.11.024. Online ahead of print. Joel R Wilkie  1 , Kimberly A Hochstedler  2 , Matthew J Schipper  3 , et al.

Treatment outcomes of re-irradiation using stereotactic ablative radiotherapy to lung: a propensity score matching analysis Radiat Oncol. 2021 Nov 18;16(1):222. doi: 10.1186/s13014-021-01948-6. Tae Hoon Lee #  1 , Dong-Yun Kim #  1 , Hong-Gyun Wu  1   2   3 , Joo Ho Lee  1 , Hak Jae Kim  4   5   6

Toxicity and efficacy of stereotactic body radiotherapy for ultra-central lung tumours: a single institution real life experience Br J Radiol. 2021 Nov 26;20210533. doi: 10.1259/bjr.20210533. Online ahead of print. Elodie Guillaume  1   2 , Ronan Tanguy  1 , Myriam Ayadi  1 , et al.

Integration of deep learning radiomics and counts of circulating tumor cells improves prediction of outcomes of early stage NSCLC patients treated with SBRT Int J Radiat Oncol Biol Phys. 2021 Nov 11;S0360-3016(21)03114-X. doi: 10.1016/j.ijrobp.2021.11.006. Online ahead of print. Dr Zhicheng Jiao  1 , Dr Hongming Li  2 , Professor Ying Xiao  3 , Dr Jay Dorsey  3 , Dr Charles B Simone  4 , Professor Steven Feigenberg  3 , Dr Gary Kao  3 , Dr Yong Fan  5

A million persons, a million dreams: a vision for a national center of radiation epidemiology and biology Int J Radiat Biol. 2021 Nov 3;1-27. doi: 10.1080/09553002.2021.1988183. Online ahead of print. John D Boice Jr  1   2 , Brian Quinn  3 , Isaf Al-Nabulsi  4 , et al.

SMALL CELL LUNG CANCER - SCLC

Integrated exposure-response analysis of efficacy and safety of lurbinectedin to support the dose regimen in small-cell lung cancer Cancer Chemother Pharmacol. 2021 Nov 5. doi: 10.1007/s00280-021-04366-3. Online ahead of print. Carlos Fernández-Teruel  1 , Salvador Fudio  1 , Rubin Lubomirov  2

Identification of Potential Prognostic and Predictive Biomarkers for Immune-Checkpoint Inhibitor Response in Small Cell Lung Cancer Med Sci Monit. 2021 Nov 1;27:e932275. doi: 10.12659/MSM.932275. Chanchan Gao  1 , Xuyu Gu  1 , Yan Chen  1 , Min Zhou  1 , Feng Jiang  1 , Shiya Zheng  2

PALLIATIVE AND SUPPORTIVE CARE

Symptom Treatment Preferences of Cancer Survivors: Does Fatigue Level Make a Difference? Cancer Nurs. 2021 Nov-Dec 01;44(6):E540-E546. doi: 10.1097/NCC.0000000000000941. Ellen Krueger  1 , Ekin Secinti, Catherine E Mosher, Patrick V Stutz, Andrea A Cohee, Shelley A Johns

Post-diagnosis BMI change is associated with non-small cell lung cancer survival Cancer Epidemiol Biomarkers Prev. 2021 Nov 2;cebp.0503.2021. doi: 10.1158/1055-9965.EPI-21-0503. Online ahead of print. Qianyu Yuan  1 , Mulong Du  2 , Elizabeth Loehrer  3 , Bruce E Johnson  4 , Justin F Gainor  5 , Michael Lanuti  5 , Yi Li  6 , David C Christiani  7

Anesthetic Management for Pulmonary Resection: Current Concepts and Improving Safety of Anesthesia Thorac Surg Clin. 2021 Nov;31(4):509-517. doi: 10.1016/j.thorsurg.2021.07.009. Daniel Ankeny  1 , Hovig Chitilian  2 , Xiaodong Bao  1

Implementation and Effectiveness of a Veterans Affairs-Based Comprehensive Lung Cancer Survivorship Program J Cardiopulm Rehabil Prev. 2021 Nov 24. doi: 10.1097/HCR.0000000000000658. Online ahead of print. Brian J Rabe  1 , Jordan W Stafford, Alisa D Hassinger, Harry S Swartzwelder, Scott L Shofer

Hope and advance care planning in advanced cancer: Is there a relationship? Cancer. 2021 Nov 17. doi: 10.1002/cncr.34034. Online ahead of print. Michael G Cohen  1 , Andrew D Althouse  2 , Robert M Arnold  3 , Hailey W Bulls  3 , Douglas B White  4 , Edward Chu  5 , Margaret Q Rosenzweig  6 , Kenneth J Smith  2 , Yael Schenker  3

Emotional Distress in Cancer Patients During the First Wave of the COVID-19 Pandemic Front Psychol. 2021 Nov 5;12:755965. doi: 10.3389/fpsyg.2021.755965. eCollection 2021. Patricia Toquero  1 , Carmen Blanco Fernández  2 , María Pilar López Martí  1 , et al.

Providers’ mediating role for medication adherence among cancer survivors PLoS One. 2021 Nov 29;16(11):e0260358. doi: 10.1371/journal.pone.0260358. eCollection 2021. Justin G Trogdon  1   2 , Krutika Amin  1 , Parul Gupta  2 , et al.

Fear of Palliative Care: Roles of Age and Depression Severity J Palliat Med. 2021 Nov 11. doi: 10.1089/jpm.2021.0359. Online ahead of print. Sarah Alonzi  1 , Laura M Perry  1 , Ashley B Lewson  2 , Brenna Mossman  1 , Madison W Silverstein  3 , Michael Hoerger  1   4   5

COMPLEMENTARY & ALTERNATIVE THERAPY

The natural product berberine synergizes with osimertinib preferentially against MET-amplified osimertinib-resistant lung cancer via direct MET inhibition Pharmacol Res. 2021 Nov 24;175:105998. doi: 10.1016/j.phrs.2021.105998. Online ahead of print. Zhen Chen  1 , Karin A Vallega  1 , Haiying Chen  2 , Jia Zhou  2 , Suresh S Ramalingam  1 , Shi-Yong Sun  3

MISCELLANEOUS WORKS

Promoting early diagnosis and recovering from the COVID-19 pandemic in lung cancer through public awareness campaigns: learning from patient and public insight work BMJ Open Respir Res. 2021 Nov;8(1):e001120. doi: 10.1136/bmjresp-2021-001120. Matthew Evison  1   2 , Sarah Taylor  3 , Seamus Grundy  4 , Anna Perkins  5 , Michael Peake  6   7

Lung Cancer Risk among Patients with Asthma-Chronic Obstructive Pulmonary Disease Overlap Ann Am Thorac Soc. 2021 Nov;18(11):1894-1900. doi: 10.1513/AnnalsATS.202010-1280OC. Antonios Charokopos  1   2 , Sidney S Braman  1 , Stacey A Whittaker Brown  1 , et al.

Health Disparities in Cancer Among American Indians and Alaska Natives Acad Radiol. 2021 Nov 18;S1076-6332(21)00480-3. doi: 10.1016/j.acra.2021.10.011. Online ahead of print. Marilyn A Roubidoux  1 , Judith S Kaur  2 , Dorothy A Rhoades  3

Impact of Clinical Trial Participation on Survival of Patients with Metastatic Non-Small Cell Lung Cancer Clin Lung Cancer. 2021 Nov;22(6):523-530. doi: 10.1016/j.cllc.2021.04.003. Epub 2021 Apr 22. Cristina M Merkhofer  1 , Keith D Eaton  2 , Renato G Martins  3 , Scott D Ramsey  4 , Bernardo H L Goulart  5

Predictors of Enrollment of Older Smokers in Six Smoking Cessation Trials in the Lung Cancer Screening Setting: The Smoking Cessation at Lung Examination (SCALE) Collaboration Nicotine Tob Res. 2021 Nov 5;23(12):2037-2046. doi: 10.1093/ntr/ntab110. Ellie Eyestone  1 , Randi M Williams  1 , George Luta  2 , et al.

A Potential Serum Biomarker for Screening Lung Cancer Risk in High Level Environmental Radon Areas: A Pilot Study Life (Basel). 2021 Nov 21;11(11):1273. doi: 10.3390/life11111273. Narongchai Autsavapromporn  1 , Pitchayaponne Klunklin  1 , Imjai Chitapanarux  1 , et al.

Using Patient-Generated Health Data From Twitter to Identify, Engage, and Recruit Cancer Survivors in Clinical Trials in Los Angeles County: Evaluation of a Feasibility Study JMIR Form Res. 2021 Nov 26;5(11):e29958. doi: 10.2196/29958. Katja Reuter  1   2 , Praveen Angyan  2 , NamQuyen Le  3 , Thomas A Buchanan  2   4

Disparities and trends in the participation of minorities, women, and the elderly in breast, colorectal, lung, and prostate cancer clinical trials Cancer. 2021 Nov 22. doi: 10.1002/cncr.33991. Online ahead of print. Juan Javier-DesLoges  1 , Tyler J Nelson  2 , James D Murphy  2 , et al.

Immune checkpoint inhibitor therapy for malignant pleural mesothelioma Lung Cancer. 2021 Nov 16;162:162-168. doi: 10.1016/j.lungcan.2021.11.006. Online ahead of print. Anna K Nowak  1 , Wee Loong Chin  2 , Synat Keam  3 , Alistair Cook  4

The need to study rural cancer outcome disparities at the local level: a retrospective cohort study in Kansas and Missouri BMC Public Health. 2021 Nov 24;21(1):2154. doi: 10.1186/s12889-021-12190-w. Jeffrey A Thompson  1   2 , Lynn Chollet-Hinton  3   4 , John Keighley  3 , Audrey Chang  5 , Dinesh Pal Mudaranthakam  3   4 , David Streeter  3   4 , Jinxiang Hu  3   4 , Michele Park  4 , Byron Gajewski  3   4

Internalized stigma among cancer patients enrolled in a smoking cessation trial: The role of cancer type and associations with psychological distress Psychooncology. 2021 Nov 19. doi: 10.1002/pon.5859. Online ahead of print. Erica T Warner  1 , Elyse R Park  2   3   4 , Christina M Luberto  2   3 , Julia Rabin  3   4 , Giselle K Perez  2   3   4 , Jamie S Ostroff  5

Racial and Ethnic Disparities Among Participants in Precision Oncology Clinical Studies JAMA Netw Open. 2021 Nov 1;4(11):e2133205. doi: 10.1001/jamanetworkopen.2021.33205. Christopher M Aldrighetti  1 , Andrzej Niemierko  1 , Eliezer Van Allen  2   3   4 , Henning Willers  1 , Sophia C Kamran  1   3

Twenty-Year Reflection on the Impact of World Trade Center Exposure on Pulmonary Outcomes in Fire Department of the City of New York (FDNY) Rescue and Recovery Workers Lung. 2021 Dec;199(6):569-578. doi: 10.1007/s00408-021-00493-z. Epub 2021 Nov 11.Krystal L Cleven  1 , Carla Rosenzvit  2 , Anna Nolan  3   4   5 , Rachel Zeig-Owens  2   3   6 , Sophia Kwon  4 , Michael D Weiden  3   4   5 , Molly Skerker  2   3 , Allison Halpren  3 , David J Prezant  2   3   6

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