Monthly PubMed Review

Monthly PubMed Review of the Most relevant research on Lung Cancer

August 2020

BASIC AND APPLIED SCIENCE, PRE-CLINICAL STUDIES

Detection of miR-155-5p and imaging lung cancer for early diagnosis: in vitro and in vivo study J Cancer Res Clin Oncol. 2020 Aug;146(8):1941-1951. doi: 10.1007/s00432-020-03246-2. Epub 2020 May 23. Hai-Zhen Zhu  1 , Chun-Ju Fang  1 , Yi Guo  2 , Qi Zhang  1 , Li-Min Huang  1 , Dong Qiu  1 , Guang-Peng Chen  3 , Xiu-Feng Pang  4 , Jian-Jun Hu  5 , Jian-Guo Sun  6 , Zheng-Tang Chen  7

The oncogenic potential of a mutant TP53 gene explored in two spontaneous lung cancer mice models BMC Cancer. 2020 Aug 8;20(1):738. doi: 10.1186/s12885-020-07212-6. Julian Ramelow  1   2   3 , Christopher D Brooks  4 , Li Gao  1 , Abeer A Almiman  1 , Terence M Williams  4 , Miguel A Villalona-Calero  5 , Wenrui Duan  6   7   8

Cells of origin of lung cancers: lessons from mouse studies Genes Dev. 2020 Aug 1;34(15-16):1017-1032. doi: 10.1101/gad.338228.120. Giustina Ferone  1 , Myung Chang Lee  2   3 , Julien Sage  2   3 , Anton Berns  1

The association between gut butyrate-producing bacteria and non-small-cell lung cancer J Clin Lab Anal. 2020 Aug;34(8):e23318. doi: 10.1002/jcla.23318. Epub 2020 Mar 29. Qifeng Gui  1 , Hanyu Li  1 , Ange Wang  1 , Xinxiu Zhao  1 , Zhongju Tan  1 , Lufang Chen  1 , Keying Xu  1 , Chi Xiao  2

Florescence Imaging Lung Cancer with a Small Molecule MHI-148 J Fluoresc. 2020 Aug 11. doi: 10.1007/s10895-020-02605-z. Online ahead of print. Xiaotian Xia  1   2 , Yongkang Gai  1   2 , Hongyan Feng  1   2 , Chunxia Qin  1   2 , Dongfeng Pan  3 , Yiling Song  1   2 , Yongxue Zhang  1   2 , Xiaoli Lan  4   5

SCREENING, DIAGNOSIS, BIOMARKER TESTING, AND STAGING

Occurrence of Discussion about Lung Cancer Screening Between Patients and Healthcare Providers in the USA, 2017 J Cancer Educ. 2020 Aug;35(4):678-681. doi: 10.1007/s13187-019-01510-9. Samir Soneji  1 , JaeWon Yang  2 , Nichole T Tanner  3   4 , Gerard A Silvestri  3

Telephone-Based Shared Decision-making for Lung Cancer Screening in Primary Care J Cancer Educ. 2020 Aug;35(4):766-773. doi: 10.1007/s13187-019-01528-z. Heather Bittner Fagan  1 , Nicole A Fournakis  2   3 , Claudine Jurkovitz  4 , Anett M Petrich  5 , Zugui Zhang  4 , Nora Katurakes  6 , Ronald E Myers  5

Risk Prediction Model versus United States Preventive Services Task Force Lung Cancer Screening Eligibility Criteria – Reducing Race Disparities J Thorac Oncol. 2020 Aug 17;S1556-0864(20)30638-9. doi: 10.1016/j.jtho.2020.08.006. Online ahead of print. Mary M Pasquinelli  1 , Martin C Tammemägi  2 , Kevin L Kovitz  3 , et al.

Low-Dose Computed Tomography: Effects of Oncology Nurse Navigation on Lung Cancer Screening Clin J Oncol Nurs. 2020 Aug 1;24(4):421-429. doi: 10.1188/20.CJON.421-429. Joni Watson  1 , Marion E Broome  2 , Susan M Schneider  2

NSCLC SURGERY

Airway inflammation and lung function recovery after lobectomy in patients with primary lung cancer Gen Thorac Cardiovasc Surg. 2020 Aug 28. doi: 10.1007/s11748-020-01464-6. Online ahead of print. Keigo Okamoto  1 , Kazuki Hayashi  2 , Ryosuke Kaku  2 , Yo Kawaguchi  2 , Yasuhiko Oshio  2 , Jun Hanaoka  2

Analyzing the Time From Discovery to Definitive Surgical Therapy for Lung Cancer Based on Referral Patterns Am J Clin Oncol. 2020 Aug;43(8):582-585. doi: 10.1097/COC.0000000000000710. Michael A Napolitano  1 , Matthew D Skancke, Keith D Mortman

Minimizing the Risk of Aerosol Contamination During Elective Lung Resection Surgery Ann Surg. 2020 Aug;272(2):e125-e128. doi: 10.1097/SLA.0000000000004087. George Rakovich  1 , Robert Urbanowicz  2 , Rami Issa  2 , Han Ting Wang  3

Clinical course of coronavirus disease 2019 in 11 patients after thoracic surgery and challenges in diagnosis J Thorac Cardiovasc Surg. 2020 Aug;160(2):585-592.e2. doi: 10.1016/j.jtcvs.2020.04.005. Epub 2020 Apr 10. Shu Peng  1 , Liu Huang  2 , Bo Zhao  1 , Shuchang Zhou  3 , Irene Braithwaite  4 , Ni Zhang  1 , Xiangning Fu  5

Clinical Outcomes of Surgical Resection for Brain Metastases from Non-small Cell Lung Cancer Anticancer Res. 2020 Aug;40(8):4801-4804. doi: 10.21873/anticanres.14483. Takayuki Nakao  1 , Takeshi Okuda  2 , Hiromasa Yoshioka  1 , Mitsugu Fujita  1   3

Outcomes of Anatomic Lung Resection for Cancer are Better When Performed by Cardiothoracic Surgeons Ann Thorac Surg. 2020 Aug 12;S0003-4975(20)31311-4. doi: 10.1016/j.athoracsur.2020.06.022. Online ahead of print. John D Vossler  1 , Ayman Abdul-Ghani  1 , Peter I Tsai  1 , Paul T Morris  2

Striving toward Improved Outcomes for Surgically Resectable Non-Small Cell Lung Cancer: the Promise and Challenges of Neoadjuvant Immunotherapy Curr Oncol Rep. 2020 Aug 15;22(11):109. doi: 10.1007/s11912-020-00969-w. Ryan D Gentzler  1 , David O Riley  2 , Linda W Martin  3

NSCLC – SYSTEMIC THERAPIES (CHEMOTHERAPY, TARGETED THERAPY, AND IMMUNOTHERAPY)

Impact of PD-1 Blockade on Severity of COVID-19 in Patients with Lung Cancers Cancer Discov. 2020 Aug;10(8):1121-1128. doi: 10.1158/2159-8290.CD-20-0596. Epub 2020 May 12. Jia Luo  1 , Hira Rizvi  1 , Jacklynn V Egger  1 , Isabel R Preeshagul  1 , Jedd D Wolchok  2   3   4 , Matthew D Hellmann  5   2   4

A Multivariable Regression Model-based Nomogram for Estimating the Overall Survival of Patients Previously Treated With Nivolumab for Advanced Non-small-cell Lung Cancer Anticancer Res. 2020 Aug;40(8):4229-4236. doi: 10.21873/anticanres.14424. Akihiro Tamiya  1 , Motohiro Tamiya  2 , Hirofumi Go  3 , et al.

Outcomes to first-line pembrolizumab in patients with PD-L1-high (≥50%) non-small cell lung cancer and a poor performance status J Immunother Cancer. 2020 Aug;8(2):e001007. doi: 10.1136/jitc-2020-001007. Joao V Alessi  1 , Biagio Ricciuti  1 , Elizabeth Jiménez-Aguilar  2 , et al.

Ipilimumab plus nivolumab and chemoradiotherapy followed by surgery in patients with resectable and borderline resectable T3-4N0-1 non-small cell lung cancer: the INCREASE trial BMC Cancer. 2020 Aug 14;20(1):764. doi: 10.1186/s12885-020-07263-9. Chris Dickhoff  1 , Suresh Senan  2 , Famke L Schneiders  2 , et al.

Chemotherapy and COVID-19 Outcomes in Patients With Cancer J Clin Oncol. 2020 Aug 14;JCO2001307. doi: 10.1200/JCO.20.01307. Online ahead of print. Justin Jee  1 , Michael B Foote  1 , Melissa Lumish  1 , et al.

Targeting PD-L1 in non-small cell lung cancer using CAR T cells  Oncogenesis. 2020 Aug 13;9(8):72. doi: 10.1038/s41389-020-00257-z. Ming Liu  1 , Xu Wang  2 , Wei Li  2 , Xinfang Yu  2 , et al.

Comparing incidences of infusion site reactions between brand-name and generic vinorelbine in patients with non-small cell lung cancer Br J Clin Pharmacol. 2020 Aug 13. doi: 10.1111/bcp.14516. Online ahead of print. Naoya Ozawa  1 , Tetsunari Hase  1 , Takahiro Hatta  1 , et al.

Efficacy and Safety of Sintilimab Plus Pemetrexed and Platinum as First-Line Treatment for Locally Advanced or Metastatic Nonsquamous NSCLC: a Randomized, Double-Blind, Phase 3 Study (Oncology pRogram by InnovENT anti-PD-1-11) J Thorac Oncol. 2020 Aug 8;S1556-0864(20)30595-5. doi: 10.1016/j.jtho.2020.07.014. Online ahead of print. Yunpeng Yang  1 , Zhehai Wang  2 , Jian Fang  3 , et al.

Brigatinib Versus Crizotinib in Advanced ALK Inhibitor-Naive ALK-Positive Non-Small Cell Lung Cancer: Second Interim Analysis of the Phase III ALTA-1L Trial J Clin Oncol. 2020 Aug 11;JCO2000505. doi: 10.1200/JCO.20.00505. Online ahead of print. D Ross Camidge  1 , Hye Ryun Kim  2 , Myung-Ju Ahn  3 , et al.

Patient-reported outcomes in RELAY, a phase 3 trial of ramucirumab plus erlotinib versus placebo plus erlotinib in untreated EGFR-mutated metastatic non-small-cell lung cancer Curr Med Res Opin. 2020 Aug 28;1-9. doi: 10.1080/03007995.2020.1808781. Online ahead of print. Kiyotaka Yoh  1 , Shinji Atagi  2 , Martin Reck  3 , et al.

Dabrafenib and Trametinib in Patients With Tumors With BRAF V600E Mutations: Results of the NCI-MATCH Trial Subprotocol H J Clin Oncol. 2020 Aug 6;JCO2000762. doi: 10.1200/JCO.20.00762. Online ahead of print. April K S Salama  1 , Shuli Li  2 , Erin R Macrae  3 , et al.

Outcomes to first-line pembrolizumab in patients with PD-L1-high (≥50%) non-small cell lung cancer and a poor performance status J Immunother Cancer. 2020 Aug;8(2):e001007. doi: 10.1136/jitc-2020-001007. Joao V Alessi  1 , Biagio Ricciuti  1 , Elizabeth Jiménez-Aguilar  2 , et al.

Comparative effectiveness of pembrolizumab vs. nivolumab in patients with recurrent or advanced NSCLC Sci Rep. 2020 Aug 4;10(1):13160. doi: 10.1038/s41598-020-70207-7.Pengfei Cui  1   2 , Ruixin Li  2 , Ziwei Huang  2   3 , Zhaozhen Wu  2   3 , Haitao Tao  2 , Sujie Zhang  2 , Yi Hu  4   5   6

ROS1-dependent cancers – biology, diagnostics and therapeutics Nat Rev Clin Oncol. 2020 Aug 5. doi: 10.1038/s41571-020-0408-9. Online ahead of print. Alexander Drilon  1   2 , Chelsea Jenkins  3 , Sudarshan Iyer  3 , Adam Schoenfeld  4   5 , Clare Keddy  3 , Monika A Davare  6

NSCLC - RADIOTHERAPY

Brain metastases of lung cancer: comparison of survival outcomes among whole brain radiotherapy, whole brain radiotherapy with consecutive boost, and simultaneous integrated boost J Cancer Res Clin Oncol. 2020 Aug 26. doi: 10.1007/s00432-020-03359-8. Online ahead of print. Tian-Qi Du  1 , Xiang Li  1 , Wei-Si Zhong  1 , Jian-Dong Tian  1 , Yu-Xia Zhao  2 , Dan Liu  3

 Functionally weighted airway sparing (FWAS): a functional avoidance method for preserving post-treatment ventilation in lung radiotherapy Phys Med Biol. 2020 Aug 19;65(16):165010. doi: 10.1088/1361-6560/ab9f5d. E Vicente  1 , A Modiri, J Kipritidis, A Hagan, K Yu, H Wibowo, Y Yan, D R Owen, M M Matuszak, P Mohindra, R Timmerman, A Sawant

Potentiating anti-tumor efficacy through radiation and sustained intratumoral delivery of anti-CD40 and anti-PDL1 Int J Radiat Oncol Biol Phys. 2020 Aug 5;S0360-3016(20)33745-7. doi: 10.1016/j.ijrobp.2020.07.2326. Online ahead of print. Hsuan-Chen Liu  1 , Dixita I Viswanath  2 , et al.

Two months of radiation oncology in the heart of Italian “red zone” during COVID-19 pandemic: paving a safe path over thin ice Radiat Oncol. 2020 Aug 10;15(1):191. doi: 10.1186/s13014-020-01631-2. Michela Buglione  1 , Luigi Spiazzi  2 , Andrea Emanuele Guerini  1 , et al.

SMALL CELL LUNG CANCER - SCLC

Atezolizumab plus carboplatin and etoposide in small cell lung cancer patients previously treated with platinum-based chemotherapy Invest New Drugs. 2020 Aug 11. doi: 10.1007/s10637-020-00983-6. Online ahead of print. Hidenobu Ishii  1 , Koichi Azuma  2 , Akihiko Kawahara  3 , Norikazu Matsuo  2 , Takaaki Tokito  2 , Tomoaki Hoshino  2

Prolonging Survival: The Role of Immune Checkpoint Inhibitors in the Treatment of Extensive-Stage Small Cell Lung Cancer Oncologist. 2020 Aug 29. doi: 10.1634/theoncologist.2020-0193. Online ahead of print. Barbara Melosky  1 , Parneet K Cheema  2 , Anthony Brade  3 , Deanna McLeod  4 , Geoffrey Liu  5 , Paul Wheatley Price  6 , Kevin Jao  7 , Devin D Schellenberg  8 , Rosalyn Juergens  9 , Natasha Leighl  5, Quincy Chu  10

Choice of second-line systemic therapy in stage IV small cell lung cancer (SCLC) – A decision-making analysis amongst European lung cancer experts Lung Cancer. 2020 Aug;146:6-11. doi: 10.1016/j.lungcan.2020.03.024. Epub 2020 Mar 30. M Früh  1 , C M Panje  2 , M Reck  3 , et al.

The impact of symptoms and comorbidity on health utility scores and health-related quality of life in small cell lung cancer using real world data Qual Life Res. 2020 Aug 26. doi: 10.1007/s11136-020-02615-1. Online ahead of print. Ali Vedadi  1 , Sharara Shakik  1   2 , M Catherine Brown  1 , et al.

PALLIATIVE AND SUPPORTIVE CARE

Prognosis in metastatic lung cancer: vitamin D deficiency and depression-a cross-sectional analysis BMJ Support Palliat Care. 2020 Aug 27;bmjspcare-2020-002457. doi: 10.1136/bmjspcare-2020-002457. Online ahead of print. Daniel C McFarland  1 , Madalyn Fernbach  2 , William S Breitbart  2 , Christian Nelson  2

Early childhood adversity in adult patients with metastatic lung cancer: Cross-sectional analysis of symptom burden and inflammation Brain Behav Immun. 2020 Aug 11;S0889-1591(20)31361-1. doi: 10.1016/j.bbi.2020.08.006. Online ahead of print. Daniel C McFarland  1 , Christian Nelson  2 , Andrew H Miller  3

Interstitial pneumonitis in the COVID-19 era: a difficult differential diagnosis in patients with lung cancer Tumori. 2020 Aug 26;300891620951863. doi: 10.1177/0300891620951863. Online ahead of print. Chiara Catania  1 , Valeria Stati  1 , Gianluca Spitaleri  1

Mechanisms of Fritillariae Thunbergii Flos in Lung Cancer Treatment from a Systems Pharmacology Perspective J Ethnopharmacol. 2020 Aug 14;113245. doi: 10.1016/j.jep.2020.113245. Online ahead of print. Mingchao Cui  1 , Shaojun Chen  2 , Hanhua Wang  2 , Ping Pan  2 , Yiyuan Luo  2, Xiuxiu Sha  2

Evaluating relationships between lung cancer stigma, anxiety, and depressive symptoms and the absence of empathic opportunities presented during routine clinical consultations Patient Educ Couns. 2020 Aug 11;S0738-3991(20)30406-7. doi: 10.1016/j.pec.2020.08.005. Online ahead of print. Timothy J Williamson  1 , Jamie S Ostroff  2 , Chloé M Martin  2 , Smita C Banerjee  2 , Carma L Bylund  3 , Heidi A Hamann  4 , Megan Johnson Shen  5

Changes in chronic medication adherence, costs, and health care use after a cancer diagnosis among low-income patients and the role of patient-centered medical homes Cancer. 2020 Aug 11. doi: 10.1002/cncr.33147. Online ahead of print. Lisa P Spees  1   2 , Stephanie B Wheeler  1   2 , Xi Zhou  2 , et al.

COMPLEMENTARY & ALTERNATIVE THERAPY

Combination of traditional Chinese medicine and epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of non-small cell lung cancer: A systematic review and meta-analysis Medicine (Baltimore). 2020 Aug 7;99(32):e20683. doi: 10.1097/MD.0000000000020683. Xinbing Sui  1   2 , Mingming Zhang  1   2 , Xuemeng Han  1   2 , Ruonan Zhang  1   2 , Liuxi Chen  1 , Ying Liu  3 , Yu Xiang  1   2 , Tian Xie  1   2

Efficacy and safety of TCM combined with chemotherapy for SCLC: a systematic review and meta-analysis J Cancer Res Clin Oncol. 2020 Aug 14. doi: 10.1007/s00432-020-03353-0. Online ahead of print. Shuntai Chen  1   2 , Yanju Bao  3 , Jing Xu  4 , et al.           

Elephantopus mollis Kunth extracts induce antiproliferation and apoptosis in human lung cancer and myeloid leukemia cells J Ethnopharmacol. 2020 Aug 5;263:113222. doi: 10.1016/j.jep.2020.113222. Online ahead of print.Truong Thi Bich Ngoc  1 , Nguyen Thi Hoai Nga  2 , Nguyen Thi My Trinh  3 , Tran Linh Thuoc  1 , Dang Thi Phuong Thao  4

MISCELLANEOUS WORKS

Rurality, Stage-Stratified Use of Treatment Modalities, and Survival of Non-small Cell Lung Cancer Chest. 2020 Aug;158(2):787-796. doi: 10.1016/j.chest.2020.04.042. Epub 2020 May 6. Meredith A Ray  1 , Nicholas R Faris  2 , Anna Derrick  3 , Matthew P Smeltzer  1 , Raymond U Osarogiagbon  4

Analyzing the Time From Discovery to Definitive Surgical Therapy for Lung Cancer Based on Referral Patterns Am J Clin Oncol. 2020 Aug;43(8):582-585. doi: 10.1097/COC.0000000000000710. Michael A Napolitano  1 , Matthew D Skancke, Keith D Mortman

Artificial intelligence for the detection of COVID-19 pneumonia on chest CT using multinational datasets Nat Commun. 2020 Aug 14;11(1):4080. doi: 10.1038/s41467-020-17971-2. Stephanie A Harmon  1   2 , Thomas H Sanford  3 , Sheng Xu  4 , et al.

Medical management of brain metastases Neurooncol Adv. 2020 Aug 9;2(1):vdaa015. doi: 10.1093/noajnl/vdaa015. eCollection Jan-Dec 2020. Adam Lauko  1 , Yasmeen Rauf  1 , Manmeet S Ahluwalia  1

Face masks: benefits and risks during the COVID-19 crisis Eur J Med Res. 2020 Aug 12;25(1):32. doi: 10.1186/s40001-020-00430-5. Christiane Matuschek  1 , Friedrich Moll  2 , Heiner Fangerau  2 , et al.

The Effect of Advances in Lung-Cancer Treatment on Population Mortality N Engl J Med. 2020 Aug 13;383(7):640-649. doi: 10.1056/NEJMoa1916623. Nadia Howlader  1 , Gonçalo Forjaz  1 , Meghan J Mooradian  1 , Rafael Meza  1 , Chung Yin Kong  1 , Kathleen A Cronin  1 , Angela B Mariotto  1 , Douglas R Lowy  1 , Eric J Feuer  1 

Vascular inflammation and endothelial injury in SARS-CoV-2 infection: The overlooked regulatory cascades implicated by the ACE2 gene cluster QJM. 2020 Aug 10;hcaa241. doi: 10.1093/qjmed/hcaa241. Online ahead of print. Claire L Shovlin  1   2 , Marcela P Vizcaychipi  3

SARS-CoV-2 Infection and Lung Cancer: Potential Therapeutic Modalities Cancers (Basel). 2020 Aug 5;12(8):E2186. doi: 10.3390/cancers12082186. Ishita Gupta  1   2 , Balsam Rizeq  1   2 , Eyad Elkord  3   4 , Semir Vranic  1 , Ala-Eddin Al Moustafa  1   2

Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection Nat Med. 2020 Aug 3. doi: 10.1038/s41591-020-1021-2. Online ahead of print. Vijendra Ramlall  1   2 , Phyllis M Thangaraj  1   3 , Cem Meydan  4   5 , et al.

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