Monthly PubMed Review

Monthly PubMed Review of the Most relevant research on Lung Cancer

February 2021


Establishing a Cohort and a Biorepository to Identify Biomarkers for Early Detection of Lung Cancer: The Nashville Lung Cancer Screening Cohort Ann Am Thorac Soc. 2021 Jan 5. doi: 10.1513/AnnalsATS.202004-344OC. Online ahead of print. Dhairya A Lakhani  1 , Sheau-Chiann Chen  2 , et al.

Major Pathologic Response in Patients Treated for Non-small Cell Carcinoma of the Lung: Is There a Magic Number in the Histologic Sections to be Evaluated? Adv Anat Pathol. 2021 Jan 4;Publish Ahead of Print. doi: 10.1097/PAP.0000000000000292. Online ahead of print. Diana M Oramas  1 , Cesar A Moran

Predictive biomarkers for response to immune checkpoint inhibitors in lung cancer: PD-L1 and beyond Virchows Arch. 2021 Jan 24. doi: 10.1007/s00428-021-03030-8. Online ahead of print. Hironori Uruga  1 , Mari Mino-Kenudson  2

Evaluation of Revised US Preventive Services Task Force Lung Cancer Screening Guideline Among Women and Racial/Ethnic Minority Populations JAMA Netw Open. 2021 Jan 4;4(1):e2033769. doi: 10.1001/jamanetworkopen.2020.33769.

Current Status and Future Perspectives of Liquid Biopsy in Small Cell Lung Cancer Biomedicines. 2021 Jan 7;9(1):48. doi: 10.3390/biomedicines9010048. Patricia Mondelo-Macía  1 , Jorge García-González  2   3   4 , Luis León-Mateos  2   3   4 , et al.

Endobronchial Ultrasound Staging of Operable NSCLC: Do Triple Normal Lymph Nodes Require Routine Biopsy? Chest. 2021 Jan 9;S0012-3692(21)00027-1. doi: 10.1016/j.chest.2020.12.050. Online ahead of print. Danielle A Hylton  1 , Biniam Kidane  2 , Jonathan Spicer  3 , et al.


Robotic Pneumonectomy for Lung Cancer: Perioperative Outcomes and Factors Leading to Conversion to Thoracotomy Innovations (Phila). 2021 Jan 15;1556984520978227. doi: 10.1177/1556984520978227. Online ahead of print. Byron D Patton  1 , Daniel Zarif  1 , Donna M Bahroloomi  1 , Iam C Sarmiento  1 , Paul C Lee  1 , Richard S Lazzaro  1

Bias Against Complex Lung Cancer Surgery Ann Thorac Surg. 2021 Jan 4;S0003-4975(21)00009-6. doi: 10.1016/j.athoracsur.2020.12.019. Online ahead of print. Mark S Allen  1 , William S Harmsen  2 , Jay Mandrekar  2 , Gaetano Rocco  3

Prospective study of recurrence at the surgical margin after wedge resection of pulmonary metastases Gen Thorac Cardiovasc Surg. 2021 Jan 3. doi: 10.1007/s11748-020-01560-7. Online ahead of print.Satoshi Shiono  1 , Noriyuki Matsutani  2 , Hiroshi Hashimoto  3 , Yoshikane Yamauchi  2 , et al.

Lobectomy with artery reconstruction and pneumonectomy for NSCLC: a propensity score weighting study Ann Thorac Surg. 2021 Jan 9;S0003-4975(21)00045-X. doi: 10.1016/j.athoracsur.2020.12.029. Online ahead of print. Marco Schiavon  1 , Giovanni Maria Comacchio  2 , Marco Mammana  2 , et al.


Recent advances and future perspectives in adjuvant and neoadjuvant immunotherapies for lung cancer Jpn J Clin Oncol. 2021 Jan 1;51(1):28-36. doi: 10.1093/jjco/hyaa187. Masaya Yotsukura  1 , Kazuo Nakagawa  1 , Kenji Suzuki  2 , et al.

First-line nivolumab plus ipilimumab combined with two cycles of chemotherapy in patients with non-small-cell lung cancer (CheckMate 9LA): an international, randomised, open-label, phase 3 trial Lancet Oncol. 2021 Jan 18;S1470-2045(20)30641-0. doi: 10.1016/S1470-2045(20)30641-0. Online ahead of print. Luis Paz-Ares  1 , Tudor-Eliade Ciuleanu  2 , Manuel Cobo  3 , et al.

Clinical utility of the C-reactive protein:albumin ratio in non-small cell lung cancer patients treated with nivolumab Thorac Cancer. 2021 Jan 12. doi: 10.1111/1759-7714.13788. Online ahead of print. Taisuke Araki  1 , Kazunari Tateishi  1 , Kei Sonehara  1 , et al.

Outcomes in patients with lung cancer treated with crizotinib and erlotinib in routine clinical practice: A post-authorization safety cohort study conducted in Europe and in the United States Pharmacoepidemiol Drug Saf. 2021 Jan 11. doi: 10.1002/pds.5193. Online ahead of print. Vera Ehrenstein  1 , Kui Huang  2 , Johnny Kahlert  1 , et al.

Improved survival and disease control following pembrolizumab-induced immune-related adverse events in high PD-L1 expressing non-small cell lung cancer with brain metastases J Neurooncol. 2021 Jan 7. doi: 10.1007/s11060-020-03686-3. Online ahead of print.Michael Zhang  1 , Adrian J Rodrigues  1 , Erqi L Pollom  2 , et al.

Brief report: Four-year survival with durvalumab after chemoradiotherapy in Stage III NSCLC – an update from the PACIFIC trial J Thorac Oncol. 2021 Jan 18;S1556-0864(21)00022-8. doi: 10.1016/j.jtho.2020.12.015. Online ahead of print.Corinne Faivre-Finn  1 , David Vicente  2 , Takayasu Kurata  3 , et al.

Efficacy of Osimertinib Plus Bevacizumab vs Osimertinib in Patients With EGFR T790M-Mutated Non-Small Cell Lung Cancer Previously Treated With Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor: West Japan Oncology Group 8715L Phase 2 Randomized Clinical Trial JAMA Oncol. 2021 Jan 7;e206758. doi: 10.1001/jamaoncol.2020.6758. Online ahead of print. Hiroaki Akamatsu  1 , Yukihiro Toi  2 , Hidetoshi Hayashi  3 , et al.


The Role of Radiation Therapy in the Older Patient Curr Oncol Rep. 2021 Jan 2;23(1):11. doi: 10.1007/s11912-020-01000-y. Ammoren Dohm  1 , Roberto Diaz  1 , Ronica H Nanda  2

Differences in patterns of recurrence of squamous cell carcinoma and adenocarcinoma after radiotherapy for stage III non-small cell lung cancer Jpn J Radiol. 2021 Jan 23. doi: 10.1007/s11604-021-01091-y. Online ahead of print. Yu Katagiri  1 , Keiichi Jingu  2 , Takaya Yamamoto  1 , et al.

The Impact of Radiotherapy on the Incidence of Secondary Malignancies: A Pan-Cancer Study in the US SEER Cancer Registries Curr Oncol. 2021 Jan 8;28(1):301-316. doi: 10.3390/curroncol28010035. Wei Li  1 , Haitao Xiao  1 , Xuewen Xu  1 , Yange Zhang  1

Safety of radiosurgery concurrent with systemic therapy (chemotherapy, targeted therapy, and/or immunotherapy) in brain metastases: a systematic review Cancer Metastasis Rev. 2021 Jan 4. doi: 10.1007/s10555-020-09949-9. Online ahead of print. Pierre-Yves Borius  1 , Jean Régis  2 , Alexandre Carpentier  3 , Michel Kalamarides  3 , Charles Ambroise Valery  3 , Igor Latorzeff  4


A comparison of mixture cure fraction models to traditional parametric survival models in estimation of the cost-effectiveness of nivolumab for relapsed small cell lung cancer J Med Econ. Jan-Dec 2021;24(1):79-86. doi: 10.1080/13696998.2020.1857960. Joshua A Roth  1 , Yong Yuan  2 , Megan Othus  1 , Mark Danese  3 , Samuel Wagner  2 , John R Penrod  2 , Scott D Ramsey  1

Updated Overall Survival and PD-L1 Subgroup Analysis of Patients With Extensive-Stage Small-Cell Lung Cancer Treated With Atezolizumab, Carboplatin, and Etoposide (IMpower133)  Clin Oncol. 2021 Jan 13;JCO2001055. doi: 10.1200/JCO.20.01055. Online ahead of print. Stephen V Liu  1 , Martin Reck  2 , Aaron S Mansfield  3 , et al.

Small-cell lung cancer Nat Rev Dis Primers. 2021 Jan 14;7(1):3. doi: 10.1038/s41572-020-00235-0. Charles M Rudin  1   2 , Elisabeth Brambilla  3 , Corinne Faivre-Finn  4   5 , Julien Sage  6   7


End-of-life patterns of symptom management and cancer-directed care among Medicare beneficiaries with lung cancer: a claims-based analysis Support Care Cancer. 2021 Jan 3. doi: 10.1007/s00520-020-05964-2. Online ahead of print. 

Cost Savings Associated With Palliative Care Among Older Adults With Advanced Cancer Am J Hosp Palliat Care. 2021 Jan 11;1049909120986800. doi: 10.1177/1049909120986800. Online ahead of print. Paige E Sheridan  1 , Wendi G LeBrett  1 , Daniel P Triplett  1 , Eric J Roeland  2 , Andrew R Bruggeman  1 , Heidi N Yeung  3 , James D Murphy  1

Examination of individual and multiple comorbid conditions and health-related quality of life in older cancer survivors Qual Life Res. 2021 Jan 14;1-11. doi: 10.1007/s11136-020-02713-0. Online ahead of print. Elizabeth J Siembida  1   2   3 , Ashley Wilder Smith  4 , Arnold L Potosky  5 , Kristi D Graves  5 , Roxanne E Jensen  4

Physiologic and psychologic adaptation to exercise interventions in lung cancer patients undergoing chemotherapy: a systematic review and meta-analysis of randomized controlled trials Support Care Cancer. 2021 Jan 6. doi: 10.1007/s00520-020-05939-3. Online ahead of print. Junga Lee  1


Herbal medicines for anorexia in lung cancer: A protocol for systematic review and meta-analysis
Medicine (Baltimore). 2020 Dec 24;99(52):e23913. doi: 10.1097/MD.0000000000023913. Ju Ah Lee  1 , Kyun Ha Kim  2 , Geum Young Ko  2 , Hwa-Seung Yoo  3 , Jun-Yong Choi  2   4   5

Efficacy and safety of Shengjiang Xiexin decoction in prophylaxis of chemotherapy-related diarrhea in small cell lung cancer patients: study protocol for a multicenter randomized controlled trial Trials. 2020 May 1;21(1):370. doi: 10.1186/s13063-020-04275-5. Chao Deng  1 , Yanni Lou  1 , Yu Gao  1   2 , Bo Deng  1 , Fei Su  1 , Liqun Jia  3


A Systematic Review and Meta-Analysis of Clinical Characteristics and Outcomes in Patients With Lung Cancer with Coronavirus Disease 2019 JTO Clin Res Rep. 2021 Mar;2(3):100141. doi: 10.1016/j.jtocrr.2020.100141. Epub 2021 Jan 7. Monica Peravali  1 , Ishani Joshi  2 , Jaeil Ahn  3 , Chul Kim  4

Lung Cancer Pre-Diagnostic Pathways from First Presentation to Specialist Referral Curr Oncol. 2021 Jan 11;28(1):378-389. doi: 10.3390/curroncol28010040.Satya Rashi Khare  1 , Sreenath Arekunnath

Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19 Semin Cancer Biol. 2021 Jan 20;S1044-579X(21)00008-0. doi: 10.1016/j.semcancer.2021.01.003. Online ahead of print. Shama Ahmad  1 , Shajer Manzoor  1 , Simmone Siddiqui  1 , Nithya Mariappan  1 , Iram Zafar  1 , Aamir Ahmad  1 , Aftab Ahmad  2

Social Media and Your Cancer Patient Semin Thorac Cardiovasc Surg. 2021 Jan 9;S1043-0679(21)00008-3. doi: 10.1053/j.semtcvs.2020.12.014. Online ahead of print. Brendon M Stiles  1 , J Nathan Mynard  2

Lung adenocarcinoma patients have higher risk of SARS-CoV-2 infection Aging (Albany NY). 2021 Jan 10;12. doi: 10.18632/aging.202375. Online ahead of print.Long Chen  1 , Yue Liu  1 , Jiamin Wu  2 , Chao Deng  3 , Jianjun Tan  3 , Huawen Liu  3 , Li Zhong  1

Recent updates on biomarkers of exposure and systemic toxicity in e-cigarette users and EVALI

Am J Physiol Lung Cell Mol Physiol. 2021 Jan 27. doi: 10.1152/ajplung.00520.2020. Online ahead of print. Samantha R McDonough  1 , Irfan Rahman  1 , Isaac Kirubakaran Sundar  2

Role of vitamin D in regulating COVID-19 severity-An immunological perspective J Leukoc Biol. 2021 Jan 19. doi: 10.1002/JLB.4COVR1020-698R. Online ahead of print. Vandana Kalia  1   2 , George P Studzinski  3 , Surojit Sarkar  1   2   4

Determination of disease severity in COVID-19 patients using deep learning in chest X-ray images Diagn Interv Radiol. 2021 Jan;27(1):20-27. doi: 10.5152/dir.2020.20205. Maxime Blain  1 , Michael T Kassin  1 , et al.