Monthly PubMed Review

May 2021

Monthly PubMed Review of the Most relevant research on Lung Cancer

SCREENING, DIAGNOSIS, BIOMARKER TESTING, AND STAGING

Patterns and Factors Associated With Adherence to Lung Cancer Screening in Diverse Practice Settings JAMA Netw Open. 2021 Apr 1;4(4):e218559. doi: 10.1001/jamanetworkopen.2021.8559. Lori C Sakoda  1   2 , M Patricia Rivera  3   4 , et al.

Adherence to National Comprehensive Cancer Network ALK Testing Guidelines for Patients with Advanced Non-Small Cell Lung Cancer in U.S. Community Medical Centers Oncologist. 2021 Apr 6. doi: 10.1002/onco.13779. Online ahead of print.

Healthcare Access, Utilization, and Preventive Health Behaviors by Eligibility for Lung Cancer Screening J Cancer Educ. 2021 Apr;36(2):330-337. doi: 10.1007/s13187-019-01634-y. Eric A Miller  1 , Paul F Pinsky  2

Video-Based Education in Lung Cancer Screening J Cancer Educ. 2021 Apr;36(2):305-309. doi: 10.1007/s13187-019-01629-9. Juan Alban  1 , Luis-Felipe Alban  2 , Andrew Clayburn  3 , Amit Khanal  4 , Lawrence Feldman  5

A Comparison of Web-Based Cancer Risk Calculators That Inform Shared Decision-making for Lung Cancer Screening J Gen Intern Med. 2021 Apr 9. doi: 10.1007/s11606-021-06754-0. Online ahead of print. Frederick R Kates  1 , Ryan Romero  2 , Daniel Jones 3 , Jacqueline Egelfeld 4 , Santanu Datta  5

Propensity-score-matching analysis to compare efficacy and safety between 16-gauge and 18-gauge needle in ultrasound-guided biopsy for peripheral pulmonary lesions BMC Cancer. 2021 Apr 9;21(1):390. doi: 10.1186/s12885-021-08126-7. Weijun Huang #  1   2 , Jieyi Ye #  2 , Yide Qiu  2 , Weiwei Peng  2 , Ninghui Lan  2 , Weizhen Cui  2 , Ting Huang  2 , Yinghui Ou  2 , Yingjia Li  3

Patient Adherence in an Academic Medical Center’s Low-dose Computed Tomography Screening Program Am J Clin Oncol. 2021 Apr 1. doi: 10.1097/COC.0000000000000817. Online ahead of print. Keith D Mortman  1 , Joseph Devlin, Brian Giang, Ryan Mortman, Andrew D Sparks, Michael A Napolitano

Molecular Biomarker and Program Death-Ligand 1 Expression Testing in Patients with Advanced Stage Non-Small Cell Lung Cancer Across North Carolina Community Hospitals Chest. 2021 Apr 19;S0012-3692(21)00702-9. doi: 10.1016/j.chest.2021.04.014. Online ahead of print. M Patricia Rivera  1 , Marjory Charlot  2 , Danielle D Durham  3 , et al.

Predicting Lymph Node Metastasis in Non-Small Cell Lung Cancer: Prospective External and Temporal Validation of the HAL and HOMER Models Chest. 2021 Apr 28;S0012-3692(21)00856-4. doi: 10.1016/j.chest.2021.04.048. Online ahead of print. Gabriela Martinez-Zayas  1 , Francisco A Almeida  2 , Lonny Yarmus  3 , et al.

A Retrospective Multi-Site Academic Center Analysis of Pneumothorax and Associated Risk Factors after CT-Guided Percutaneous Lung Biopsy Lung. 2021 Apr 19. doi: 10.1007/s00408-021-00445-7. Online ahead of print. Esther Rong  1 , David A Hirschl  2 , Benjamin Zalta  2 , Anna Shmukler  2   3 , Steven Krausz  2 , Jeffrey M Levsky  2 , Juan Lin  4 , Linda B Haramati  2 , Arash Gohari  2

Augmented Fluoroscopy: A New and Novel Navigation Platform for Peripheral Bronchoscopy J Bronchology Interv Pulmonol. 2021 Apr 1;28(2):116-123. doi: 10.1097/LBR.0000000000000722. Joseph Cicenia  1 , Krish Bhadra  2 , Sonali Sethi  1 , Daniel A Nader  3 , Patrick Whitten  4 , Douglas Kyle Hogarth  5

EBUS-TBNA Cytological Samples for Comprehensive Molecular Testing in Non-Small Cell Lung Cancer Cancers (Basel). 2021 Apr 25;13(9):2084. doi: 10.3390/cancers13092084. Roberto Martin-Deleon  1 , Cristina Teixido  2   3 , et al.

NSCLC SURGERY

Combination of nitrous oxide and the modified inflation-deflation method for identifying the intersegmental plane in segmentectomy: A randomized controlled trial Thorac Cancer. 2021 May;12(9):1398-1406. doi: 10.1111/1759-7714.13919. Epub 2021 Apr 4. Wenjing Yang #  1 , Zicheng Liu #  2 , Chun Yang  1 , et al. Shijiang Liu  1 , Minna Guo  1 , Wei Wen  2 , Jun Wang  2 , Cunming Liu  1 , Quan Zhu  2

Targeted Sequencing Analysis of Predominant Histological Subtypes in Resected Stage I Invasive Lung Adenocarcinoma J Cancer. 2021 Apr 2;12(11):3222-3229. doi: 10.7150/jca.51405. eCollection 2021. Yan Li  1   2 , Yan Tan  3 , Song Hu  1 , Jun Xie  1 , Zhantao Yan  3 , Xian Zhang  1 , Yun Zong  1, Han Han-Zhang  4 , Qing Li  3 , Chong Li  1

Impact of the Extent of Lymph Node Dissection on Precise Staging and Survival in Clinical I-II Pure-Solid Lung Cancer Undergoing Lobectomy J Natl Compr Canc Netw. 2021 Jan 28;19(4):393-402. doi: 10.6004/jnccn.2020.7635. Print 2021 Apr. Donglai Chen 1, Yiming Mao 2 , Junmiao Wen  3  4 , et al.

Redefining the Risk of Surgery for Clinical Stage IIIA (N2) Non-Small Cell Lung Cancer: A Pooled Analysis of the STS GTSD and ESTS Registry Lung. 2021 Apr 28. doi: 10.1007/s00408-021-00447-5. Online ahead of print. Andrew T Arndt  1 , Alessandro Brunelli  2 , Silvia Cicconi  3 , et al.

NSCLC – SYSTEMIC THERAPIES (CHEMOTHERAPY, TARGETED THERAPY, AND IMMUNOTHERAPY)

Poziotinib for EGFR and HER2 exon 20 insertion mutation in advanced NSCLC: Results from the expanded access program Eur J Cancer. 2021 May;149:235-248. doi: 10.1016/j.ejca.2021.02.038. Epub 2021 Apr 2. Arsela Prelaj  1 , Achille Bottiglieri  2 , Claudia Proto  2 , et al.

Safety and Efficacy of First-Line Pembrolizumab in Black Patients with Metastatic Non-Small Cell Lung Cancer Oncologist. 2021 Apr 12. doi: 10.1002/onco.13787. Online ahead of print. Monica Peravali  1 , Jaeil Ahn  2 , Kevin Chen  3 , Suman Rao  3 , Irina Veytsman  1 , Stephen V Liu  4 , Chul Kim  4

A Phase Ib/II Study of Pepinemab in Combination with Avelumab in Advanced Non-Small Cell Lung Cancer Clin Cancer Res. 2021 Apr 5. doi: 10.1158/1078-0432.CCR-20-4792. Online ahead of print. Michael R Shafique  1 , Terrence L Fisher  2 , Elizabeth E Evans  3 , et al.

Real-world outcomes of first-line pembrolizumab plus pemetrexed-carboplatin for metastatic nonsquamous NSCLC at US oncology practices Sci Rep. 2021 Apr 28;11(1):9222. doi: 10.1038/s41598-021-88453-8. Vamsidhar Velcheti  1 , Xiaohan Hu  2 , Bilal Piperdi  2   3 , Thomas Burke  2

Five-Year Outcomes With Pembrolizumab Versus Chemotherapy for Metastatic Non-Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score ≥ 50 J Clin Oncol. 2021 Apr 19;JCO2100174. doi: 10.1200/JCO.21.00174. Online ahead of print. Martin Reck  1 , Delvys Rodríguez-Abreu  2 , Andrew G Robinson  3 , et al.

Osimertinib versus osimertinib plus chemotherapy for non-small cell lung cancer with EGFR (T790M)-associated resistance to initial EGFR inhibitor treatment: An open-label, randomised phase 2 clinical trial Eur J Cancer. 2021 May;149:14-22. doi: 10.1016/j.ejca.2021.02.019. Epub 2021 Apr 1. Kentaro Tanaka  1 , Hajime Asahina  2 , Junji Kishimoto  3 , et al.

Pemetrexed Plus Platinum With or Without Pembrolizumab in Patients With Previously Untreated Metastatic Nonsquamous NSCLC: Protocol-Specified Final Analysis From KEYNOTE-189 Ann Oncol. 2021 Apr 21;S0923-7534(21)01146-7. doi: 10.1016/j.annonc.2021.04.008. Online ahead of print. Authors Speranza  7 , F De Angelis  7 , M Dómine  8 , et al.

Evaluation of Pathologic Response in Lymph Nodes of Patients With Lung Cancer Receiving Neoadjuvant Chemotherapy J Thorac Oncol. 2021 Apr 20;S1556-0864(21)02109-2. doi: 10.1016/j.jtho.2021.03.029. Online ahead of print. Apar Pataer  1 , Annikka Weissferdt  2 , Ara A Vaporciyan  3 , et al.

Pembrolizumab Plus Chemotherapy or Anlotinib vs. Pembrolizumab Alone in Patients With Previously Treated EGFR-Mutant NSCLC Front Oncol. 2021 Apr 16;11:671228. doi: 10.3389/fonc.2021.671228. eCollection 2021. Ya Chen  1 , Zhengyu Yang  1 , et al.

Perilesional edema in brain metastases as predictive factor of response to systemic therapy in non-small cell lung cancer patients: a preliminary study Ann Transl Med. 2021 Apr;9(8):648. doi: 10.21037/atm-20-6497. Montse Alemany  1 , Marta Domènech  2 , Andreas A Argyriou  3 , et al. Noelia Vilariño  1   2 , Carles Majós  1   4 , Pablo Naval-Baudin  4 , Anna Lucas  1 , Ramón Palmero  2 ,

NSCLC - RADIOTHERAPY

Local failure after stereotactic radiosurgery (SRS) for intracranial metastasis: analysis from a cooperative, prospective national registry J Neurooncol. 2021 Apr;152(2):299-311. doi: 10.1007/s11060-021-03698-7. Epub 2021 Jan 22. Anthony L Asher  1 , Mohammed Ali Alvi  2 , et al.

Systemic effect of radiotherapy before or after nivolumab in lung cancer: an observational, retrospective, multicenter study Tumori. 2021 Apr 4;3008916211004733. doi: 10.1177/03008916211004733. Online ahead of print. Maria Bassanelli  1 , Biagio Ricciuti  2 , Diana Giannarelli  3 , et al.

Radiomics predicts risk of cachexia in advanced NSCLC patients treated with immune checkpoint inhibitors Br J Cancer. 2021 Apr 7. doi: 10.1038/s41416-021-01375-0. Online ahead of print. Wei Mu  1 , Evangelia Katsoulakis  2 , Christopher J Whelan  1 , Kenneth L Gage  3 , Matthew B Schabath  4   5 , Robert J Gillies  6

Higher biologically effective dose is associated with improved survival in patients with squamous cell carcinoma of the lung treated with stereotactic body radiation therapy Radiother Oncol. 2021 Apr 21;160:25-31. doi: 10.1016/j.radonc.2021.04.010. Online ahead of print. Jacob S Parzen  1 , Muayad F Almahariq  2 , Thomas J Quinn  1 , Zaid A Siddiqui  3 , Andrew B Thompson  1 , Thomas Guerrero  1 , Kuei Lee  1 , Craig Stevens  1 , Inga S Grills  1

The HILUS-Trial-a Prospective Nordic Multicenter Phase 2 Study of Ultracentral Lung Tumors Treated With Stereotactic Body Radiotherapy J Thorac Oncol. 2021 Apr 3;S1556-0864(21)02074-8. doi: 10.1016/j.jtho.2021.03.019. Online ahead of print. Karin Lindberg  1 , Vitali Grozman  2 , Kristin Karlsson  3 , et al.

Stereotactic body radiotherapy with a high maximum dose improves local control, cancer-specific death and overall survival in peripheral early-stage non-small cell lung cancer Int J Radiat Oncol Biol Phys. 2021 Apr 20;S0360-3016(21)00375-8. doi: 10.1016/j.ijrobp.2021.04.014. Online ahead of print. Yudai Tateishi  1 , Atsuya Takeda  2 , Nobuyuki Horita  3 , Yuichiro Tsurugai  4 , Takahisa Eriguchi  5 , Yuichi Kibe  6 , Naoko Sanuki  7 , Takeshi Kaneko  8

Radiation and Modulation of the Tumor Immune Microenvironment in Non-Small Cell Lung Cancer Semin Radiat Oncol. 2021 Apr;31(2):133-139. doi: 10.1016/j.semradonc.2020.11.010. Peter H Goff  1 , Jing Zeng  2 , Ramesh Rengan  2 , Stephanie K Schaub  2

Impact of Radiotherapy Pattern on the Prognosis of Stage IV Lung Adenocarcinomas Harboring EGFR Mutations Cancer Manag Res. 2021 Apr 15;13:3293-3301. doi: 10.2147/CMAR.S299563. eCollection 2021. Yingyun Zhang  1   2 , Wei Wang  1   2 , Xuedong Xu  1   2 , Yankang Li  1   3 , Hui Zhang  4 , Jianbin Li  1   2 , Zhenxiang Li  1

SMALL CELL LUNG CANCER - SCLC

Efficacy and Safety of Niraparib as Maintenance Treatment in Patients with Extensive-Stage Small Cell Lung Cancer after First-Line Chemotherapy: A Randomized, Double-Blind, Phase 3 Study J Thorac Oncol. 2021 Apr 26;S1556-0864(21)02111-0. doi: 10.1016/j.jtho.2021.04.001. Online ahead of print. Xinghao Ai  1 , Yueyin Pan  2 , Jianhua Shi  3 , et al.

Chemotherapy in idiopathic pulmonary fibrosis and small-cell lung cancer with poor lung function BMC Pulm Med. 2021 Apr 15;21(1):122. doi: 10.1186/s12890-021-01489-4. Xiyue Zhang  1 , Wei Li  1 , Chunyan Li  1 , Jie Zhang  2 , Zhenzhong Su  3

Promising Role of Circulating Tumor Cells in the Management of SCLC Cancers (Basel). 2021 Apr 22;13(9):2029. doi: 10.3390/cancers13092029. Antonella De Luca  1 , Marianna Gallo  1 , Claudia Esposito  1 , Alessandro Morabito  2 , Nicola Normanno  1

PALLIATIVE AND SUPPORTIVE CARE

Symptom Treatment Preferences of Cancer Survivors: Does Fatigue Level Make a Difference? Cancer Nurs. 2021 Apr 21. doi: 10.1097/NCC.0000000000000941. Online ahead of print. Ellen Krueger  1 , Ekin Secinti, Catherine E Mosher, Patrick V Stutz, Andrea A Cohee, Shelley A Johns

“Randomized trial of physical activity on quality of life and lung cancer biomarkers in patients with advanced stage lung cancer: a pilot study” BMC Cancer. 2021 Apr 1;21(1):352. doi: 10.1186/s12885-021-08084-0. Brett C Bade  1 , Geliang Gan  2 , Fangyong Li  2 , Lingeng Lu  3 , Lynn Tanoue  4 , Gerard A Silvestri  5 , Melinda L Irwin  3

Distress experienced by lung cancer patients and their family caregivers in the first year of their cancer journey Palliat Support Care. 2021 Apr 26;1-7. doi: 10.1017/S1478951521000377. Online ahead of print. Michèle Aubin  1   2   3 , Lucie Vézina  1 , René Verreault  3 , et al.

Functional Decline as an Indicator of Ill-Health: A Retrospective Case Study of the Process Leading to Lung Cancer J Multidiscip Healthc. 2021 Apr 27;14:919-927. doi: 10.2147/JMDH.S295498. eCollection 2021. Lesleigh Kowalski  1

Incidence and Risk Factors of Pneumonitis in Patients with Non-Small Cell Lung Cancer: An Observational Analysis of Real-World Data Oncol Ther. 2021 Apr 28. doi: 10.1007/s40487-021-00150-8. Online ahead of print. Jerzy E Tyczynski  1 , Ravi Potluri  2 , Ryan Kilpatrick  3 , Debasish Mazumder  4 , Anirban Ghosh  4 , Alexander Liede  3   5

Determining Risk Factors Associated with Depression and Anxiety in Young Lung Cancer Patients: A Novel Optimization Algorithm Medicina (Kaunas). 2021 Apr 1;57(4):340. doi: 10.3390/medicina57040340 Yu-Wei Fang  1   2 , Chieh-Yu Liu  3   4

Role of myokines and osteokines in cancer cachexia Exp Biol Med (Maywood). 2021 Apr 25;15353702211009213. doi: 10.1177/15353702211009213. Online ahead of print. Fabrizio Pin  1 , Lynda F Bonewald  1   2   3 , Andrea Bonetto  1   2   3   4   5

Variation in Use of High-Cost Technologies for Palliative Radiation Therapy by Radiation Oncologists J Natl Compr Canc Netw. 2021 Feb 12;19(4):421-431. doi: 10.6004/jnccn.2020.7633. Print 2021 Apr. Aileen B Chen  1 , Jiangong Niu  1 , Angel M Cronin  2 , Ya-Chen Tina Shih  1 , Sharon Giordano  1 , Deborah Schrag  2

COMPLEMENTARY & ALTERNATIVE THERAPY

Phase I Study of Muscadine Grape Extract for Patients With Advanced Cancer Am J Clin Oncol. 2021 Apr 19. doi: 10.1097/COC.0000000000000814. Online ahead of print. Rhonda L Bitting  1 , Janet A Tooze, Scott Isom, et al.

A Combined Phytochemistry and Network Pharmacology Approach to Reveal Potential Anti-NSCLC Effective Substances and Mechanisms in Marsdenia tenacissima (Roxb.) Moon (Stem) Front Pharmacol. 2021 Apr 29;12:518406. doi: 10.3389/fphar.2021.518406. eCollection 2021. Pei Liu  1   2 , Dong-Wei Xu  1   2 , Run-Tian Li  1   2 , et al.

Clinical observation of Yiqi Qingdu prescription on the treatment of intermediate-stage and advanced non-small-cell lung cancer J Tradit Chin Med. 2021 Apr;41(2):308-315. Qijun Liang  1 , Xiaoling Tang  2 , Jiong Yu  3 , Monian Xiong  3 , Huifang Zhu  4 , Linkai Xiong  5 , Ru Zeng  4 , Peiwen Yu  4    

Nutrient supplements from selected botanicals mediated immune modulation of the tumor microenvironment and antitumor mechanism Cancer Immunol Immunother. 2021 Apr 20. doi: 10.1007/s00262-021-02927-2. Online ahead of print. Hui-Ming Chen  1   2   3 , Linus Sun  4 , Ping-Ying Pan  1   2   3 , Lu-Hai Wang  5 , Shu-Hsia Chen  6   7   8   9

The Use of Traditional Chinese Medicine in Relieving EGFR-TKI-Associated Diarrhea Based on Network Pharmacology and Data Mining Evid Based Complement Alternat Med. 2021 Apr 1;2021:5530898. doi: 10.1155/2021/5530898. eCollection 2021. Shuaihang Hu  1   2 , Wenchao Dan  1   2 , Jinlei Liu  1   2 , Peng Ha  3 , Tong Zhou  1 , Xinyuan Guo  4 , Wei Hou  1

MISCELLANEOUS WORKS

Cancer Mortality Disparities among Asian American and Native Hawaiian/Pacific Islander Populations in California  Cancer Epidemiol Biomarkers Prev. 2021 Apr 20;cebp.1528.2020. doi: 10.1158/1055-9965.EPI-20-1528. Online ahead of print. Heidy N Medina  1 , Karen E Callahan  2 , Cyllene R Morris  3 , Caroline A Thompson  4 , Adugna Siweya  2 , Paulo S Pinheiro  5

What Does a Cardio-oncology Service Offer to the Oncologist and the Haematologist? Clin Oncol (R Coll Radiol). 2021 Apr 5;S0936-6555(21)00103-5. doi: 10.1016/j.clon.2021.03.012. Online ahead of print. M S Andres  1 , J Pan  2 , A R Lyon  3

Beliefs About the Health Effects of Smoking Among Adults in the United States Health Educ Behav. 2021 Apr 17;10901981211004136. doi: 10.1177/10901981211004136. Online ahead of print. Sarah D Mills  1  2 , Christopher A Wiesen  3

Population-based estimates of survival among elderly patients with brain metastases Neuro Oncol. 2021 Apr 12;23(4):661-676. doi: 10.1093/neuonc/noaa233.Nayan Lamba  1 , Rachel Brigell Kearney  1 , Paul J Catalano  2 , Michael J Hassett  3 , Patrick Y Wen  4 , Daphne A Haas-Kogan  1 , Ayal A Aizer  1

Experiences of Inuit in Canada who travel from remote settings for cancer care and impacts on decision making BMC Health Serv Res. 2021 Apr 13;21(1):328. doi: 10.1186/s12913-021-06303-9. Janet Jull  1 , Amanda J Sheppard  2 , et al. .

Line of therapy and patient preferences regarding lung cancer treatment: a discrete-choice experiment Curr Med Res Opin. 2021 Apr;37(4):643-653. doi: 10.1080/03007995.2021.1888707. Epub 2021 Mar 1. Sarah Janse  1 , Ellen Janssen  2 , Tanya Huwig  1 , Upal Basu Roy  3 , Andrea Ferris  3 , Carolyn J Presley  4 , John F P Bridges  1   5

Dynamic Management of Lung Cancer Care During Surging COVID-19 Front Surg. 2021 Apr 7;8:663364. doi: 10.3389/fsurg.2021.663364. eCollection 2021. Annie Wang  1 , Stephanie H Chang  2 , Eric J Kim  3 , Jamie L Bessich  4 , Joshua K Sabari  4 , Benjamin Cooper  5 , Travis C Geraci  2 , Robert J Cerfolio  2

Understanding the patient journey to diagnosis of lung cancer BMC Cancer. 2021 Apr 14;21(1):402. doi: 10.1186/s12885-021-08067-1. Yichen Zhang  1 , Michael J Simoff  2 , David Ost  3 , Oliver J Wagner  4 , James Lavin  4 , Beth Nauman  5 , Mei-Chin Hsieh  6 , Xiao-Cheng Wu  6 , Brian Pettiford 7, Lizheng Shi  1

Coronavirus 2019 Infectious Disease Epidemic: Where We Are, What Can Be Done and Hope For J Thorac Oncol. 2021 Apr;16(4):546-571. doi: 10.1016/j.jtho.2020.12.014. Epub 2021 Jan 7. Michele Carbone  1 , John Lednicky  2 , Shu-Yuan Xiao  3 , Mario Venditti  4 , Enrico Bucci  5

Archives