Monthly PubMed Review

Monthly PubMed Review of the Most relevant research on Lung Cancer

May 2020


Lung CSC-derived Exosomal miR-210-3p Contributes to a Pro-Metastatic Phenotype in Lung Cancer by Targeting FGFRL1 Li Wang 1 2, Jun He 1, Haoyue Hu 1, Li Tu 1 , Zhen Sun 2 , Yanyang Liu 1 , Feng Luo 1 J Cell Mol Med. 2020 May 12. doi: 10.1111/jcmm.15274. Online ahead of print.

Comparison of the Efficacy of EGFR Tyrosine Kinase Inhibitors Erlotinib and Low-dose Osimertinib on a PC-9-GFP EGFR Mutant Non-small-cell Lung Cancer Growing in the Brain of Nude Mice  Yuki Katsuya 1 2 , Kentaro Miyake 1 2 , Takashi Higuchi 1 2 , et al. In Vivo. May-Jun 2020;34(3):1027-1030. doi: 10.21873/invivo.11871.

Microarray Expression Profiling of Long Noncoding RNAs in the Progesterone-Treated Lung Cancer Cells  Mingxuan Xie 1 2 , Xiaoxiao Lu 3, Qiong Chen 1  2 J Gene Med. 2020 May 11;e3215. doi: 10.1002/jgm.3215. Online ahead of print.

IMPAD1 Functions as Mitochondrial Electron Transport Inhibitor That Prevents ROS Production and Promotes Lung Cancer Metastasis Through the AMPK-Notch1-HEY1 Pathway Yi-Fang Yang  1 , Yen-Yun Wang  2 , Michael Hsiao  3 , et al. Steven Lo  4 , Yu-Chan Chang  5 , Yi-Hua Jan  5 , Tsung-Ching Lai 5 , Yi-Chen Lee 6 , Ya-Ching Hsieh 7, Cancer Lett. 2020 May 15;485:27-37. doi: 10.1016/j.canlet.2020.04.025. Online ahead of print.


Prognostic Selection and Long-Term Survival Analysis to Assess Overdiagnosis Risk in Lung Cancer Screening Randomized Trials Eugenio Paci 1, Donella Puliti 2, Francesca Maria Carozzi 3, et al. J Med Screen. 2020 May 21;969141320923030. doi: 10.1177/0969141320923030.

Liquid Biopsies Using Circulating Tumor DNA in Non-Small Cell Lung Cancer Bruna Pellini 1, Jeffrey Szymanski 2, Re-I Chin 2  Paul A Jones 2, Aadel A Chaudhuri 3 Thorac Surg Clin. 2020 May;30(2):165-177. doi: 10.1016/j.thorsurg.2020.01.005.

Screening Mammography Visits as Opportunities to Engage Smokers With Tobacco Cessation Services and Lung Cancer Screening Gary X Wang  1 , Anand K Narayan  2 , Elyse R Park  3 , Constance D Lehman  2 , Jonina T Gorenstein  4 , Efren J Flores  2. J Am Coll Radiol. 2020 May;17(5):606-612. doi: 10.1016/j.jacr.2019.12.008. Epub 2020 Jan 10.

Collection and Handling of Thoracic Small Biopsy and Cytology Specimens for Ancillary Studies Guideline From the College of American Pathologists (CAP): Implications for the Cytology Community Paul A VanderLaan 1 J Am Soc Cytopathol. 2020 May 18;S2213-2945(20)30058-2. doi: 10.1016/j.jasc.2020.04.001. Online ahead of print.

Molecular Testing on Bronchial Washings for the Diagnosis and Predictive Assessment of Lung Cancer Roberta Roncarati 1 2, Laura Lupini 1, Elena Miotto 1, et al.  Mol Oncol. 2020 May 22. doi: 10.1002/1878-0261.12713. Online ahead of print.

A Rapid Liquid Biopsy of Lung Cancer by Separation and Detection of Exfoliated Tumor Cells From Bronchoalveolar Lavage Fluid With a Dual-Layer “PERFECT” Filter System Tingyu Li 1, Yaoping Liu 1  2, Wei Zhang 3, et al. Theranostics. 2020 May 17;10(14):6517-6529. doi: 10.7150/thno.44274. eCollection 2020.

Results of Lung Cancer Screening in the Community John R Handy Jr 1, Michael Skokan 2, Erika Rauch 3, Steven Zinck 4, Rachel E Sanborn 5, Svetlana Kotova 6, Mansen Wang 7 Ann Fam Med. 2020 May;18(3):243-249. doi: 10.1370/afm.2519.

Relationships and Qualitative Evaluation Between Diffusion-Weighted Imaging and Pathologic Findings of Resected Lung Cancers Katsuo Usuda 1, Shun Iwai 1, Aika Yamagata , et al. Cancers (Basel). 2020 May 8;12(5):E1194. doi: 10.3390/cancers12051194.

Classifying Non-Small Cell Lung Cancer Types and Transcriptomic Subtypes Using Convolutional Neural Networks Kun-Hsing Yu 1, Feiran Wang 2, Gerald J Berry 3, Christopher Ré  4, Russ B Altman  5  6  7, Michael Snyder 7, Isaac S Kohane 1 J Am Med Inform Assoc. 2020 May 1;27(5):757-769. doi: 10.1093/jamia/ocz230.

Safe Performance of Diagnostic bronchoscopy/EBUS During the SARS-CoV-2 Pandemic Daniel P Steinfort 1  2, Felix J F Herth 3  4, Louis B Irving 1, Phan T Nguyen  5 Respirology. 2020 May 13;10.1111/resp.13843. doi: 10.1111/resp.13843. Online ahead of print.

Exploring the Impact of Lung Cancer Screening on Lung Cancer Mortality of Smokers With Obstructive Lung Disease: Analysis of the NLST-ACRIN Cohort Juan P de-Torres 1, Juan P Wisnivesky 2, Gorka Bastarrika 3, David O Wilson 4, Bartolome R Celli 5, Javier J Zulueta 6 Arch Bronconeumol. 2020 May 12;S0300-2896(20)30104-6. doi: 10.1016/j.arbres.2020.03.023. Online ahead of print.

Education Level Predicts Appropriate Follow-Up of Incidental Findings From Lung Cancer Screening  Suraj Kapoor 1, Stephen A Deppen  2, Alexis B Paulson  3, Diane Haddad  4, James P Cook 3, Kim L Sandler 3. J Am Coll Radiol. 2020 May;17(5):613-619. doi: 10.1016/j.jacr.2019.12.014. Epub 2020 Jan 10.

Values of Different Specimen Preparation Methods for the Diagnosis of Lung Cancer by Endobronchial Ultrasound Guided Transbronchial Needle Aspiration Youzu Xu 1 , Jian Lin 1, Meifang Chen 2, Haihong Zheng 3, Jiaxi Feng 1 et al.  BMC Pulm Med. 2020 May 15;20(1):140. doi: 10.1186/s12890-020-01183-x.


The Association of Nodal Upstaging With Surgical Approach and Its Impact on Long-Term Survival After Resection of Non-Small-Cell Lung Cancer Mark W Hennon  1   2, Luke H DeGraaff  2, Adri Eur J Cardiothorac Surg. 2020 May 1;57(5):888-895. doi: 10.1093/ejcts/ezz320.enne Groman  3, Todd L Demmy  1   2, Sai Yendamuri  1  2

Complex Sleeve Lobectomy Has the Same Surgical Outcome When Compared With Conventional Lobectomy in Patients With Lung Cancer Ilhan Inci 1, Martina Benker 1, Necati Çitak 1 2, Didier Schneiter  1, Claudio Caviezel  1, Sven Hillinger  1, Isabelle Opitz  1, Walter Weder  1 Eur J Cardiothorac Surg. 2020 May 1;57(5):860-866. doi: 10.1093/ejcts/ezz357.

Outcomes of Lobectomy on Pulmonary Function for Early Stage Non-Small Cell Lung Cancer (NSCLC) Patients With Chronic Obstructive Pulmonary Disease (COPD) Sen Wei1 , Feng Chen 1 , Renwang Liu 1 2 , et al.  Thorac Cancer. 2020 May 6. doi: 10.1111/1759-7714.13445. Online ahead of print.


Treatment- And Immune-Related Adverse Events of Immune Checkpoint Inhibitors in Advanced Lung Cancer Jun Shao 1, Chengdi Wang 1, Pengwei Ren 2, Yuting Jiang 3  Panwen Tian 1, Weimin Li  1 Biosci Rep. 2020 May 29;40(5):BSR20192347. doi: 10.1042/BSR20192347.

Duration of Nivolumab for Pretreated, Advanced Non-Small-Cell Lung Cancer Margaux Geier  1 , Renaud Descourt  1 , Romain Corre  2 , et al. Cancer Med. 2020 May 15. doi: 10.1002/cam4.3120. Online ahead of print.

PIOS (Patras Immunotherapy Score) Score Is Associated With Best Overall Response, Progression-Free Survival, and Post-Immunotherapy Overall Survival in Patients With Advanced Non-Small-Cell Lung Cancer (NSCLC) Treated With Anti-Program Cell Death-1 (PD-1) Inhibitors Cancers (Basel). 2020 May 16;12(5):E1257. doi: 10.3390/cancers12051257. Foteinos-Ioannis Dimitrakopoulos  1 2 , Achilleas Nikolakopoulos 1 , Anastasia Kottorou , et al. Cancers (Basel). 2020 May 16;12(5):E1257. doi: 10.3390/cancers12051257.

Serum Markers Associated With Treatment Response and Survival in Non-Small Cell Lung Cancer Patients Treated With anti-PD-1 Therapy Kazuki Takada 1, Shinkichi Takamori 2, Yasuto Yoneshima 3, et al. Lung Cancer. 2020 Jul;145:18-26. doi: 10.1016/j.lungcan.2020.04.034. Epub 2020 May 5.

Efficacy of Immunotherapy Targeting the Neoantigen Derived From EGFR T790M/C797S Mutation in Non-Small Cell Lung Cancer Yu Akazawa  1 2 , Yuki Saito 1 , Toshiaki Yoshikawa 1 , et al. Cancer Sci. 2020 May 11. doi: 10.1111/cas.14451. Online ahead of print.

Predictive and Prognostic Impact of Primary Tumor-Bearing Lobe in Nonsmall Cell Lung Cancer Patients Treated With anti-PD-1 Therapy Shinkichi Takamori  1 , Kazuki Takada  2 ,  et al. Int J Cancer. 2020 May 1. doi: 10.1002/ijc.33030. Online ahead of print.

Adjuvant and Neoadjuvant Immunotherapy in Non-small Cell Lung Cancer Stephen R Broderick 1 Thorac Surg Clin. 2020 May;30(2):215-220. doi: 10.1016/j.thorsurg.2020.01.001.

Principles of Immunotherapy in Non-Small Cell Lung Cancer Melinda L Hsu  1 , Jarushka Naidoo  2 Thorac Surg Clin. 2020 May;30(2):187-198. doi: 10.1016/j.thorsurg.2020.01.009.

Immune Checkpoint Inhibitors for Lung Cancer Treatment: A Review Keisuke Onoi 1, Yusuke Chihara 1, Junji Uchino 1, et al.  J Clin Med. 2020 May 6;9(5):E1362. doi: 10.3390/jcm9051362.

PD-L1 Expression and Response to Pembrolizumab in Patients With EGFR-mutant Non-Small Cell Lung Cancer Eriko Miyawaki 1, Haruyasu Murakami 1  Keita Mori 2 , et al. Jpn J Clin Oncol. 2020 May 5;50(5):617-622. doi: 10.1093/jjco/hyaa033.

Acquired Resistance to Osimertinib in Patients With Non-Small-Cell Lung Cancer: Mechanisms and Clinical Outcomes Yuxin Mu 1, Xuezhi Hao 1, Puyuan Xing 1, et al. J Cancer Res Clin Oncol. 2020 May 8. doi: 10.1007/s00432-020-03239-1. Online ahead of print.

Systemic Treatment of Brain Metastases in Non-Small Cell Lung Cancer Simon Page 1 , Charlotte Milner-Watts 1, Marco Perna  2, et al. Eur J Cancer. 2020 Jun;132:187-198. doi: 10.1016/j.ejca.2020.03.006. Epub 2020 May 4.

Programmed Death Ligand 1 Heterogeneity and Its Impact on Benefit From Immune Checkpoint Inhibitors in Non-Small-Cell Lung Cancer Lingzhi Hong 1, Marcelo V Negrao  2, Seyedeh S Dibaj  3, et al. Runzhe Chen 2, Alexandre Reuben 2, Jadi M Bohac  2, Xiaoke Liu 2, Ferdinandos Skoulidis  2, Carl M G J Thorac Oncol. 2020 May 7;S1556-0864(20)30373-7. doi: 10.1016/j.jtho.2020.04.026. Online ahead of print.

A Phase II Study of Osimertinib for Patients With Radiotherapy-Naïve CNS Metastasis of Non-Small Cell Lung Cancer: Treatment Rationale and Protocol Design of the OCEAN Study (LOGIK 1603/WJOG 9116L) Kazushige Wakuda 1, Hiroyuki Yamaguchi 2, Hirotsugu Kenmotsu 3, et al.  BMC Cancer. 2020 May 1;20(1):370. doi: 10.1186/s12885-020-06874-6.

Efficacy of Immunotherapy Targeting the Neoantigen Derived From EGFR T790M/C797S Mutation in Non-Small Cell Lung Cancer Yu Akazawa  1 2 , Yuki Saito 1 , Toshiaki Yoshikawa  et al. Cancer Sci. 2020 May 11. doi: 10.1111/cas.14451. Online ahead of print.


Radiation-Induced Secondary Cancer Risk Assessment in Patients With Lung Cancer After Stereotactic Body Radiotherapy Using the CyberKnife M6 System With Lung-Optimized Treatment Pei-Ju Chao 1 2  I-Hsing Tsai 1  Chun-Chieh Huang  2 , et al. Front Bioeng Biotechnol. 2020 May 7;8:306. doi: 10.3389/fbioe.2020.00306. eCollection 2020.

Radiation Pneumonitis in Lung Cancer Patients Treated With Chemoradiation Plus Durvalumab Narek Shaverdian  1 , Maria Thor  2 , Annemarie F Shepherd  1 , et al. Cancer Med. 2020 May 6. doi: 10.1002/cam4.3113. Online ahead of print.

Cardiovascular Mortality and Morbidity Following Radical Radiotherapy for Lung Cancer: Is Cardiovascular Death Under-Reported? F Sun  1, K Franks  2, L Murray , J Lilley  4 , B Wheller  5 , K Banfill  6 , A McWilliam  7 , A Abravan  8 , M Van Herk  9, C Faivre-Finn  10, R Cubbon  11. Lung Cancer. 2020 May 13;146:1-5. doi: 10.1016/j.lungcan.2020.05.004. Online ahead of print.

Stereotactic Body Radiation Therapy for Early-Stage Non-Small-Cell Lung Cancer in Octogenarians and Older: An Alternative Treatment Yanping Bei  1   2, Naoya Murakami  1, Yuko Nakayama  1, et al. J Radiat Res. 2020 May 8;rraa027. doi: 10.1093/jrr/rraa027. Online ahead of print.

Radiotranscriptomics Signature-Based Predictive Nomograms for Radiotherapy Response in Patients With Nonsmall Cell Lung Cancer: Combination and Association of CT Features and Serum miRNAs Levels Liyuan Fan 1 2, Qiang Cao 3  Xiuping Ding  2, Dongni Gao 1, Qiwei Yang 1, Baosheng Li 2. Cancer Med. 2020 May 27. doi: 10.1002/cam4.3115. Online ahead of print.


Rationale and Protocol Design for the TORG1835/NEXT-SHIP Study: A Phase II Study of Carboplatin, Etoposide and Nintedanib for Unresectable Limited/Extensive Disease Small Cell Lung Cancer With Idiopathic Pulmonary Fibrosis Satoshi Ikeda 1, Takashi Ogura 2, Terufumi Kato 3, et al. Ther Adv Med Oncol. 2020 May 18;12:1758835920923431. doi: 10.1177/1758835920923431. eCollection 2020.

Once Daily Versus Twice-Daily Radiotherapy in the Management of Limited Disease Small Cell Lung Cancer – Decision Criteria in Routine Practice Markus Glatzer 1, Corinne Faivre-Finn 2, Dirk De Ruysscher 3, et al. Radiother Oncol. 2020 May 21;S0167-8140(20)30246-2. doi: 10.1016/j.radonc.2020.05.004. Online ahead of print.

Inhibition of p62/SQSTM1 Sensitizes Small-Cell Lung Cancer Cells to Cisplatin-Induced Cytotoxicity by Targeting NEDD9 Expression Lingzhi Xu  1 , Fan Xu  1 , Qingxia Kong  1 , et al. Mol Carcinog. 2020 May 19. doi: 10.1002/mc.23215. Online ahead of print.


The Role of Malnutrition and Muscle Wasting in Advanced Lung Cancer Rishi Jain 1 , Chris Coss 2  Peter Whooley 2, Mitch Phelps 2, Dwight H Owen 4 Curr Oncol Rep. 2020 May 15;22(6):54. doi: 10.1007/s11912-020-00916-9.

Genetic Polymorphisms and Haplotypes of BRCA1 Gene Associated With Quality of Life and Survival Among Patients With Non-Small-Cell Lung Cancer Tong Su  1  , Hao Sun  , Xiaofang Lu  4, Chen  1 , Lei Xiao   , Jingwen H  1, Yang Yang  5, Yunxiang Tang  6 7 Qual Life Res. 2020 May 18. doi: 10.1007/s11136-020-02509-2. Online ahead of print.

Exercise Prescription for Symptoms and Quality of Life Improvements in Lung Cancer Patients: A Systematic Review Alberto Codima 1, Willian das Neves Silva 1  2 , Ana Paula de Souza Borges  1 2 ,

Evaluation of Nutritional Status in Non-Small-Cell Lung Cancer: Screening, Assessment and Correlation With Treatment Outcome Ilaria Trestini  1 , Isabella Sperduti  2 , Marco Sposito  1 , et al.  ESMO Open. 2020 May;5(3):e000689. doi: 10.1136/esmoopen-2020-000689.


Evaluation of Anticancer Effects of a Pharmaceutically Viable Extract of a Traditional Polyherbal Mixture Against Non-Small-Cell Lung Cancer Cells Varuni Colamba Pathiranage 1, Ira Thabrew 1, Sameera R Samarakoon 2 , Kamani H Tennekoon  1, Umapriyatharshini Rajagopalan 1, Meran K Ediriweera 1. Affiliations J Integr Med. 2020 May;18(3):242-252. doi: 10.1016/j.joim.2020.02.007. Epub 2020 Feb 20.


Sex-specificity in Lung Cancer Risk Claudia Stapelfeld 1, Christine Dammann 1, Edmund Maser 1 Int J

Smoking Is Associated With Pneumonia Development in Lung Cancer Patients Jung Won Heo  1 , Chang Dong Yeo  1 , Chan Kwon Park  2, et al.  BMC Pulm Med. 2020 May 1;20(1):117. doi: 10.1186/s12890-020-1160-8.

Treatment Guidance for Patients With Lung Cancer During the Coronavirus 2019 Pandemic Anne-Marie C Dingemans 1, Ross A Soo 2, Abdul Rahman Jazieh 3, J Thorac Oncol. 2020 May 15;S1556-0864(20)30382-8. doi: 10.1016/j.jtho.2020.05.001. Online ahead of print.

Could Venous Thromboembolism and Major Bleeding Be Indicators of Lung Cancer Mortality? A Nationwide Database Study Jennifer Howlett 1  2, Eric Benzenine  2 3, Jonathan Cottenet  2  3, Pascal Foucher  4, Philippe Fagnoni  1   5 , Catherine Quantin  6 7 8 BMC Cancer. 2020 May 24;20(1):461. doi: 10.1186/s12885-020-06930-1.

Evidence That Established Lung Cancer Mortality Disparities in American Indians Are Not Due to Lung Cancer Genetic Testing and Targeted Therapy Disparities Abbie Begnaud 1, Ping Yang 2, Camille Robichaux 3, Nathan Rubin 4 , Robert Kratzke 1, Anne Melzer  5, Constantin Aliferis  1 , Pamala Jacobson  6 Clin Lung Cancer. 2020 May;21(3):e164-e168. doi: 10.1016/j.cllc.2019.10.012. Epub 2019 Oct 30.

Smoking Is Associated With Pneumonia Development in Lung Cancer Patients Jung Won Heo 1, Chang Dong Yeo 1, Chan Kwon Park 2, et al. BMC Pulm Med. 2020 May 1;20(1):117. doi: 10.1186/s12890-020-1160-8.Hye Seon Kang  8

Primary Lung Cancer Diagnoses in People Living With HIV in a Large Clinical Centre in Montreal, Canada Over 3 Decades Béatrice Bichara 1, Jean-Pierre Routy  2 3 , Nicole Ezer  4 5, Cecilia T Costiniuk 2 6 AIDS Care. 2020 May 6;1-5. doi: 10.1080/09540121.2020.1758614. Online ahead of print.

Lung Cancer Incidence and Mortality in Relationship to Hormone Replacement Therapy Use Among Women Participating in the PLCO Trial: A Post Hoc Analysis Omar Abdel-Rahman 1 2 Int J Clin Oncol. 2020 May;25(5):885-891. doi: 10.1007/s10147-020-01615-y. Epub 2020 Jan 9.

Lung Cancer Surgical Regionalization Disproportionately Worsens Travel Distance for Rural Patients Joshua N Herb  1 , Lisette N Dunham  2 , Gita Mody  1 , Jason M Long  1 , Karyn B Stitzenberg  1. J Rural Health. 2020 May 1. doi: 10.1111/jrh.12440. Online ahead of print.